Cytodiagnosis of Pancreatic Malignant Tumors by Aspiration, Under Direct Vision, Using a Duodenal Fiberscope

Endo, Yoshihiko; Morii, Takeshi; Tamura, Hiroshi; Okuda, Shujiro

doi:10.1016/s0016-5085(19)32748-9

Cited by 117 publications

(28 citation statements)

References 6 publications

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“…To detect pancreatic cancer at an early stage, it is essential to perform examinations of the pancreatic juice from patients who have abnormal pancreatograms shown by endoscopic retrograde pancreatography (ERP), even if no tumor image is shown by ultrasonography (US), endoscopic ultrasonography (EUS), or computed tomography (CT) (4). Pancreatic juice cytology is a reliable method for the diagnosis of pancreatic cancer (5,6), but its diagnostic rates are not always satisfactory (7)(8)(9)(10)(11). Detection of K-ras and p53 alterations in pancreatic juice may be helpful for the diagnosis of pancreatic cancer (12)(13)(14)(15), but the specificity of these gene abnormalities to pancreatic cancer is controversial (16,17).…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Pancreatic Cancer by Detecting Telomerase Activity in Pancreatic Juice: Comparison With K- Ras Mutations

Uehara¹,

Nakaizumi²,

Tatsuta³

et al. 1999

American Journal of Gastroenterology

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Section: Introductionmentioning

confidence: 99%

Diagnosis of Pancreatic Cancer by Detecting Telomerase Activity in Pancreatic Juice: Comparison With K- Ras Mutations

Uehara¹,

Nakaizumi²,

Tatsuta³

et al. 1999

American Journal of Gastroenterology

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“…Some authors (Endo et al, 1974;Hatfield et al, 1976) have reported good results from pancreatic cytology when juice was collected from the main pancreatic duct or from the orifice of the papilla of Vater after exogenous pancreatic stimulation. In other studies (Cotton, 1977) the results of pancreatic cytology obtained by aspiration were rather poor in patients with pancreatic malignancies.…”

Section: Discussionmentioning

confidence: 99%

“…The study further shows that many of the malignant tumours found by ERP are secondary lesions. Cytology is often able to detect malignancy when ERP has proved inconclusive.Pancreatic cytology may be obtained by duodenal aspiration (Asnaes and Johansen, 1970;Olsen, 1971), or by endoscopic cannulation of the main pancreatic duct (Endo et al, 1974;Hatfield et al, 1976) after exogenous pancreatic stimulation. In a previous publication (Osnes et al, 1975) we reported on our preliminary results using a special brush device which allows direct brush cytology of the pancreatic duct during endoscopic retrograde cholangiopancreatography (ERCP).…”

mentioning

confidence: 99%

Endoscopic retrograde brush cytology in patients with primary and secondary malignancies of the pancreas.

Osnes¹,

Serck-Hanssen²,

Kristensen³

et al. 1979

Gut

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25 October 1978 because of obvious changes due to pancreatic carcinoma (n = 12) beyond the reach of the brush device, technical difficulties (n = 11), or lack of cytological service or equipment to perform cytology (n = 5).Ductal abnormalities were demonstrated by ERCP in all patients (Fig. 1), and were strongly suggestive of malignancy in 58 cases and uncertain in 11 patients. Specimens for histological examination were obtained during surgery in 45 cases and at necropsy in 24 cases. In 12 patients the malignancy were found to be secondary (Fig. 2, Table 1). The ductal abnormality was demonstrated in the head of the pancreas in 45 cases, in the body in 15 cases, and in the tail in nine cases. Islet cell tumours were found in two out of 57 patients with primary pancreatic lesions; the others were adenocarcinoma.For ERBC a polyvinyl tube with side-viewing openings at the side were constructed as described in a previous paper (Osnes et al., 1975). A modification of this brush device (Fig. 3) with three instead of five side-viewing openings seems to be more suitable for retrograde brushing. For ERBC in patients with a narrow papillary opening a thinner brush, measuring 1-4 mm in diameter, has been constructed.

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“…At the present time endoscopic retrograde cholangiopancreatography (ERCP) with or without aspiration or brush cytology (Endo et al, 1974;Osnes et al, 1975;Hatfield et al, 1976;Wood et al, 1976) remains the best method for confirming the diagnosis of pancreatic cancer. The true predictive value of this technique is high for lesions of the head and periampullary region but it often misses lesions of the body and tail.…”

Section: Discussionmentioning

confidence: 99%

Value of laparoscopy in the diagnosis and management of pancreatic carcinoma.

Cuschieri¹,

Hall²,

Clark³

1978

Gut

170

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SUMMARY Our experience with laparoscopy in the diagnosis and staging of 23 cases of pancreatic cancer is reported. This endoscopic procedure has proved useful in the diagnosis of the disease, in the assessment of operability, and in the retrieval of material for histological and cytological confirmation of pancreatic cancer. An infra-gastric laparoscopic method for inspection of the body and tail of the pancreas is described and the technique may allow the earlier detection of neoplasms in this region.

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Cytodiagnosis of Pancreatic Malignant Tumors by Aspiration, Under Direct Vision, Using a Duodenal Fiberscope

Cited by 117 publications

References 6 publications

Diagnosis of Pancreatic Cancer by Detecting Telomerase Activity in Pancreatic Juice: Comparison With K- Ras Mutations

Diagnosis of Pancreatic Cancer by Detecting Telomerase Activity in Pancreatic Juice: Comparison With K- Ras Mutations

Endoscopic retrograde brush cytology in patients with primary and secondary malignancies of the pancreas.

Value of laparoscopy in the diagnosis and management of pancreatic carcinoma.

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