CYP722C from Gossypium arboreum catalyzes the conversion of carlactonoic acid to 5-deoxystrigol

Wakabayashi, Takatoshi; Shida, Kasumi; Kitano, Yurie; Takikawa, Hirosato; Mizutani, Masaharu; Sugimoto, Yukihiro

doi:10.1007/s00425-020-03390-6

Cited by 75 publications

(66 citation statements)

References 24 publications

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“…In addition, hydroxylation of 4-deoxyorobanchol to orobanchol has been shown for Os-CYP711A3 (Zhang et al, 2014;Yoneyama et al, 2018). CYP722Cs act downstream of the most common CYP711A reaction and convert carlactonoic acid to orobanchol, or to the stereoisomer 5-doxystrigol in some plants such as tree cotton (Gossypium arboreum) (Wakabayashi et al, 2019(Wakabayashi et al, , 2020.…”

Section: Cyp Families With Recently Elucidated Functionalitiesmentioning

confidence: 99%

Plant cytochrome P450 plasticity and evolution

et al. 2021

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The superfamily of cytochrome P450 (CYP) enzymes plays key roles in plant evolution and metabolic diversification. This review provides a status on the CYP landscape within green algae and land plants. The 11 conserved CYP clans known from vascular plants are all present in green algae and several green algaespecific clans are recognized. Clan 71, 72, and 85 remain the largest CYP clans and include many taxaspecific CYP (sub)families reflecting emergence of linage-specific pathways. Molecular features and dynamics of CYP plasticity and evolution are discussed and exemplified by selected biosynthetic pathways. High substrate promiscuity is commonly observed for CYPs from large families, favoring retention of gene duplicates and neofunctionalization, thus seeding acquisition of new functions. Elucidation of biosynthetic pathways producing metabolites with sporadic distribution across plant phylogeny reveals multiple examples of convergent evolution where CYPs have been independently recruited from the same or different CYP families, to adapt to similar environmental challenges or ecological niches. Sometimes only a single or a few mutations are required for functional interconversion. A compilation of functionally characterized plant CYPs is provided online through the Plant P450 Database (erda.dk/public/vgrid/PlantP450/).

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Section: Cyp Families With Recently Elucidated Functionalitiesmentioning

confidence: 99%

Plant cytochrome P450 plasticity and evolution

et al. 2021

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“…Recent studies have implicated that the diversity of canonical and non‐canonical SLs is due in part to the later steps after CLA synthesis by CYP711As. For canonical SLs, two groups recently revealed that the CYP722C subfamily plays a role in synthesizing both strigol‐ and ORO‐type canonical SLs (Wakabayashi et al ., 2019; Wakabayashi et al ., 2020; Mori et al ., 2020a) (Figure 2). VuCYP722C and SlCYP722C were demonstrated to convert CLA to ORO probably via 18‐hydroxy‐CLA in cowpea ( Vigna unguiculata ) and tomato ( Solanum lycopersicum ), respectively (Wakabayashi et al ., 2019).…”

Section: Sl Biosynthesismentioning

confidence: 99%

“…Notably, the SlCYP722C ‐defective mutant did not show the increased shoot branching phenotype as observed in the Slccd8 mutant, implicating that ORO‐type SLs may not be the branch‐inhibiting hormones in tomato (Wakabayashi et al ., 2019). Furthermore, GaCYP722C was shown to catalyze the reaction from CLA to 5‐deoxystrigol (5DS), a strigol‐type canonical SL, in cotton ( Gossypium arboreum ) (Wakabayashi et al ., 2020). Moreover, in Lotus japonicus , LjCYP722C was proposed to function in 5DS biosynthesis downstream of CYP711A9/LjMAX1, which produces 18‐hydroxy‐CLA via CLA (Mori et al ., 2020a; Mori et al ., 2020b).…”

Section: Sl Biosynthesismentioning

confidence: 99%

Strigolactone biosynthesis, transport and perception

2020

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Summary Strigolactones (SLs) are plant hormones that regulate diverse developmental processes and environmental responses. They are also known to be root‐derived chemical signals that regulate symbiotic and parasitic interactions with arbuscular mycorrhizal fungi and root parasitic plants, respectively. Since the discovery of the hormonal function of SLs in 2008, there has been much progress in the SL research field. In particular, a number of breakthroughs have been achieved in our understanding of SL biosynthesis, transport and perception. The discovery of the hormonal function of SL was quite valuable not only as the identification of a new class of plant hormones, but also as the discovery of the long‐sought‐after SL biosynthetic and response mutants. These mutants in several plant species provided us the genetic resources to address fundamental questions regarding SL biosynthesis and perception. Such mutants were further characterized later, and biochemical analyses of these genetically identified factors have uncovered the outline of SL biosynthesis and perception so far. Moreover, new genes involved in SL transport have been discovered through reverse genetic analyses. In this review, we summarize recent advances in SL research with a focus on biosynthesis, transport and perception.

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“…50) MAX1 homologs from rice and spike moss convert CL to 4DO in vitro, and the in vitro conversion of CLA to 5DS by a CYP722C from cotton (Gossypium arboretum) has recently been achieved. 51) To date, enzymes involved in the biosynthesis of the non-canonical SLs-avenanol, heliolactone, zealactone, pyranozealactone, and lotuslactone-have not been identified although they appear to be derived from MeCLA or its derivatives as they are C 20 compounds. Among plant species producing these SLs, wild oat (Avena strigosa), sunflower (Helianthus annuus), maize, and L. japonicus, only L. japonicus produces canonical SL, 5DS, 52) and the others do not produce detectable levels of known canonical SLs.…”

Section: Biosynthetic Pathway Of Slsmentioning

confidence: 99%

Recent progress in the chemistry and biochemistry of strigolactones

Yoneyama

2020

J. Pestic. Sci.

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Strigolactones (SLs) are plant secondary metabolites derived from carotenoids. SLs play important roles in the regulation of plant growth and development in planta and coordinate interactions between plants and other organisms including root parasitic plants, and symbiotic and pathogenic microbes in the rhizosphere. In the 50 years since the discovery of the first SL, strigol, our knowledge about the chemistry and biochemistry of SLs has advanced explosively, especially over the last two decades. In this review, recent advances in the chemistry and biology of SLs are summarized and possible future outcomes are discussed.

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CYP722C from Gossypium arboreum catalyzes the conversion of carlactonoic acid to 5-deoxystrigol

Cited by 75 publications

References 24 publications

Plant cytochrome P450 plasticity and evolution

Plant cytochrome P450 plasticity and evolution

Strigolactone biosynthesis, transport and perception

Recent progress in the chemistry and biochemistry of strigolactones

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