Cyclotriphosphate associated to fluoride increases hydroxyapatite resistance to acid attack

Abstract

This study evaluated the effect of sodium trimetaphosphate (TMP) associated or not with fluoride (F) on the structure and dissolution of carbonated hydroxyapatite (CHA). Synthetic CHA powder (1.0 g) was suspended in solutions containing TMP at 0-10%, associated with 0, 1100, 4500, or 9000 ppm F, and the precipitates were submitted to a pH cycle (n = 6/group). Samples were analyzed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction. F, calcium (Ca) and phosphorous (P) concentrations were determined in CHA, while P and F were analyzed in the supernatants. Data were submitted to analysis of variance, Student-Newman-Keuls' test and Pearson's correlation coefficient (α = 0.05). Solutions containing 1100 ppm F with TMP between 2-4% and 4500 and 9000 ppm F with TMP between 4 and 8% led to higher Ca/P ratio (p < 0.05) in CHA. Alkali-soluble F deposition was directly related to TMP concentrations whereas an inverse pattern was observed for acid-soluble F incorporation (p < 0.05). Greater P adsorption in the CHA structure was observed with increasing concentrations of TMP for the 0 and 1100 ppm F solutions (p < 0.05). All diffractograms and FTIR spectra showed a similar pattern to that for pure hydroxyapatite. Thus, when TMP and F are coadministered, TMP interferes with F deposition on CHA, and an ideal TMP:F ratio can enhance the precipitation of CHA with lower solubility. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2553-2564, 2018.

Evaluation of new compositions of 10% hydrogen peroxide‐based bleaching agents containing trimetaphosphate and fluoride on enamel demineralization

“…Those concentrations were based on previous studies that showed the effect of two low‐fluoride dentifrices against tooth erosion containing: 250 ppm F in combination with 0.25% TMP (22) and 500 ppm F in combination with 3% TMP (21). Studies have shown that TMP is capable of binding to the dental substrate through hydroxyl (27) and/or amino sites and this induces the precipitation of calcium phosphate apatite (23, 24), when combined with fluoride in the ratio used in the present study (21, 22, 27). In the present study, cross‐sectional hardness profiles confirmed these data up to 180 µ m depth in the enamel (Fig.…”

“…The present study evaluated if the addition of TMP and NaF at two different concentrations to 10% H 2 O 2 bleaching gels would inhibit the enamel demineralization and thereby minimize enamel alterations and consequently decrease tooth sensitivity. It is important to mention that when TMP is not combined with fluoride, it does not lead to a significant reduction in enamel demineralization (26, 27). Thus, the present study tested the ability of the compound formed by the combination of TMP with NaF at different concentrations to reduce the enamel demineralization resulting from the by‐products of H 2 O 2 application.…”

Protective Effect of Fluoride Varnish Containing Trimetaphosphate against Dentin Erosion and Erosion/Abrasion: An in vitro Study

“…TMP is adsorbed on the dentin surface, mainly by the amino and hydroxyl groups of collagen [Leone et al, 2008] and hydroxyapatite [Delbem et al, 2014;Amaral et al, 2018], respectively. As is a cyclophosphate, it produces a negative polarity of the surface increases [Neves et al, 2018], enhancing the deposition of calcium phosphate apatite [Favretto et al, 2018].…”

“…Furthermore, sodium trimetaphosphate (TMP) is an inorganic phosphate which, when added to fluoride varnishes, reduces enamel erosion by at least 50% compared to the effect of other formulations that contain the same fluoride concentration Manarelli et al, 2014]. TMP has the ability to adsorb on enamel through hydroxyl sites [Delbem et al, 2014;Amaral et al, 2018], thus enhancing the effects of the varnish against enamel erosion [Manarelli et al, 2013;Moretto et al, 2013].…”

Surface Free Energy, Interaction, and Adsorption of Calcium and Phosphate to Enamel Treated with Trimetaphosphate and Glycerophosphate

“…Solutions containing TMP (CAS 7785-84-4; Sigma-Aldrich Co., St. Louis, MO, USA) were prepared at concentrations of 1% (pH 6.04), 3% (pH 6.21), 9% (pH 5.89) [Amaral et al, 2018], and 0% (without TMP, distilled/deionized water). CaGP-containing solutions (β-isomer, CAS 58409-70-4; Sigma-Aldrich Chemistry, St. Louis, MO, USA) were formulated at concentrations of 0.25% (pH 7.52), 0.5% (pH 7.78), 1.0% (pH 9.22) [Zaze et al, 2014], and 0% (without CaGP, water).…”