2012
DOI: 10.1016/j.jconrel.2011.12.016
|View full text |Cite
|
Sign up to set email alerts
|

Cyclosporin pro-dispersion liposphere formulation

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
10
0

Year Published

2012
2012
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 22 publications
(10 citation statements)
references
References 16 publications
0
10
0
Order By: Relevance
“…The clinical usefulness of SEDDS, which stems from their ability to increase the solubility and oral bioavailability of poorly soluble drugs, have led to them attracting considerable interest [ 127 ]. Products, such as Sandimmune ® Neoral (cyclosporin A), Fortovase ® (saquinavir) and Norvir ® (ritonavir), have confirmed the value of this approach [ 128 ]. PTL401 is the proprietary PNL-based formulation of THC and CBD.…”
Section: Current Drug Dosage Forms and Novel Delivery Systemsmentioning
confidence: 99%
“…The clinical usefulness of SEDDS, which stems from their ability to increase the solubility and oral bioavailability of poorly soluble drugs, have led to them attracting considerable interest [ 127 ]. Products, such as Sandimmune ® Neoral (cyclosporin A), Fortovase ® (saquinavir) and Norvir ® (ritonavir), have confirmed the value of this approach [ 128 ]. PTL401 is the proprietary PNL-based formulation of THC and CBD.…”
Section: Current Drug Dosage Forms and Novel Delivery Systemsmentioning
confidence: 99%
“…Because of highly hydrophobic properties, topical formulation of cyclosporin A is prepared using different vegetable oils, resulting in a poor local tolerance by the patients [92] and low bioavailability. Multiple studies have supported the use of topical cyclosporine to treat DED caused by insufficient tear production [93,94]. The use of colloidal carriers such as micelles, nanoparticles, and liposomes is a promising approach to obtain better tolerance and ocular bioavailability and is discussed separately (Section 8) for treatment of DES.…”
Section: Cyclosporinmentioning
confidence: 99%
“…Lipospheres are solid microparticles (0.2-100 m), composed of solid hydrophobic fat core stabilized by a monolayer of phospholipids molecules. Prodispersion liposphere formulation of cyclosporine has been prepared and its topical use in treatment of DES can be investigated [93].…”
Section: Colloidal Carrier Systems For Treatment Of Kcsmentioning
confidence: 99%
“…Avramoff et al 33 performed a work on prodispersion liposphere for the delivery of lipophilic drug Cyclosporin. In this formulation, a homogeneous solution was prepared containing Cyclosporin, surfactants, ethyl lactate and lipids.…”
Section: Novel Formulation Approaches For the Treatment Of Psoriasismentioning
confidence: 99%
“…The main advantages of this formulation were the achievement of improved bioavailability for water insoluble drugs and stability under normal conditions for about 2 years. 33 …”
Section: Novel Formulation Approaches For the Treatment Of Psoriasismentioning
confidence: 99%