Cyclosporin pro-dispersion liposphere formulation

Avramoff, Avi; Khan, Wahid; Ezra, Aviva; Elgart, Anna; Hoffman, Amnon; Domb, Abraham J.

doi:10.1016/j.jconrel.2011.12.016

Cited by 22 publications

(10 citation statements)

References 16 publications

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“…The clinical usefulness of SEDDS, which stems from their ability to increase the solubility and oral bioavailability of poorly soluble drugs, have led to them attracting considerable interest [ 127 ]. Products, such as Sandimmune ® Neoral (cyclosporin A), Fortovase ® (saquinavir) and Norvir ® (ritonavir), have confirmed the value of this approach [ 128 ]. PTL401 is the proprietary PNL-based formulation of THC and CBD.…”

Section: Current Drug Dosage Forms and Novel Delivery Systemsmentioning

confidence: 99%

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Bruni¹,

et al. 2018

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There is a growing body of evidence to suggest that cannabinoids are beneficial for a range of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms of multiple sclerosis, anorexia, schizophrenia and other conditions. The transformation of cannabinoids from herbal preparations into highly regulated prescription drugs is therefore progressing rapidly. The development of such drugs requires well-controlled clinical trials to be carried out in order to objectively establish therapeutic efficacy, dose ranges and safety. The low oral bioavailability of cannabinoids has led to feasible methods of administration, such as the transdermal route, intranasal administration and transmucosal adsorption, being proposed. The highly lipophilic nature of cannabinoids means that they are seen as suitable candidates for advanced nanosized drug delivery systems, which can be applied via a range of routes. Nanotechnology-based drug delivery strategies have flourished in several therapeutic fields in recent years and numerous drugs have reached the market. This review explores the most recent developments, from preclinical to advanced clinical trials, in the cannabinoid delivery field, and focuses particularly on pain and inflammation treatment. Likely future directions are also considered and reported.

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Section: Current Drug Dosage Forms and Novel Delivery Systemsmentioning

confidence: 99%

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Bruni¹,

et al. 2018

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“…Because of highly hydrophobic properties, topical formulation of cyclosporin A is prepared using different vegetable oils, resulting in a poor local tolerance by the patients [92] and low bioavailability. Multiple studies have supported the use of topical cyclosporine to treat DED caused by insufficient tear production [93,94]. The use of colloidal carriers such as micelles, nanoparticles, and liposomes is a promising approach to obtain better tolerance and ocular bioavailability and is discussed separately (Section 8) for treatment of DES.…”

Section: Cyclosporinmentioning

confidence: 99%

“…Lipospheres are solid microparticles (0.2-100 m), composed of solid hydrophobic fat core stabilized by a monolayer of phospholipids molecules. Prodispersion liposphere formulation of cyclosporine has been prepared and its topical use in treatment of DES can be investigated [93].…”

Section: Colloidal Carrier Systems For Treatment Of Kcsmentioning

confidence: 99%

A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges

Phadatare

Momin

Nighojkar

et al. 2015

Advances in Pharmaceutics

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Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear film caused by decreased tear production or increased evaporation and manifests with a wide variety of signs and symptoms. The present review from interpretation of the literature gives detailed information on the prevalence, definition, causes, diagnostic tests, and medical management of dry eye disease. A number of systems contribute to the physiological integrity of the ocular surface and disruption of system may or may not produce symptoms. Therefore accurate diagnosis of dry eyes with no or minimal disruption of physiological function is necessary. The paper also discusses different colloidal drug delivery systems and current challenges in the development of topical ophthalmic drug delivery systems for treatment of KCS. Due to the wide prevalence and number of factors involved, newer, more sensitive diagnostic techniques and novel therapeutic agents have been developed to provide ocular delivery systems with high therapeutic efficacy. The aim of this review is to provide awareness among the patients, health care professionals, and researchers about diagnosis and treatment of KCS and recent developments and future challenges in management of dry eye disease.

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“…Avramoff et al 33 performed a work on prodispersion liposphere for the delivery of lipophilic drug Cyclosporin. In this formulation, a homogeneous solution was prepared containing Cyclosporin, surfactants, ethyl lactate and lipids.…”

Section: Novel Formulation Approaches For the Treatment Of Psoriasismentioning

confidence: 99%

“…The main advantages of this formulation were the achievement of improved bioavailability for water insoluble drugs and stability under normal conditions for about 2 years. 33 …”

Section: Novel Formulation Approaches For the Treatment Of Psoriasismentioning

confidence: 99%

Progress in psoriasis therapy via novel drug delivery systems

Vincent¹,

Ramya²,

Narayanan³

2014

Dermatol Reports

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Psoriasis is a lifelong condition which is caused by the negative signals produced by immune system, which leads to hyper proliferation and other inflammatory reactions on the skin. In this case, keratinocytes which are the outermost layer of skin possess shortened life cycle and results in the alteration of desquamation process where the cytokines will come out through lesions of affected patients and as a result, scaling marks appears on the skin. These conditions may negatively affect the patient’s quality of life and lead to psychosocial stress. Psoriasis can be categorized as mild, moderate and severe conditions. Mild psoriasis leads to the formation of rashes, and when it becomes moderate, the skin turns into scaly. In severe conditions, red patches may be present on skin surface and becomes itchy. Topical therapy continues to be one of the pillars for psoriasis management. Drug molecules with target effect on the skin tissues and other inflammations should be selected for the treatment of psoriasis. Most of the existing drugs lead to systemic intoxication and dryness when applied in higher dose. Different scientific approaches for topical delivery are being explored by researches including emollient, modified gelling system, transdermal delivery, spray, nanogels, hydrogels, micro/nano emulsion, liposomes, nano capsules etc. These topical dosage forms are evaluated for various physico chemical properties such as drug content, viscosity, pH, extrudability, spreadability, toxicity, irritancy, permeability and drug release mechanism. This review paper focus attention to the impact of these formulation approaches on various anti-psoriasis drugs for their successful treatment.

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Cyclosporin pro-dispersion liposphere formulation

Cited by 22 publications

References 16 publications

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges

Progress in psoriasis therapy via novel drug delivery systems

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