Cyclosporin A‐Induced Gingival Overgrowth in Renal Transplant Patients

Afonso, M.; Bello, V. de Oliveira; Shibli, Jamil Awad; Sposto, M. R.

doi:10.1902/jop.2003.74.1.51

Cited by 35 publications

(41 citation statements)

References 27 publications

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“…Gingival inflammation and gingival hyperplasia related to cyclosporine are the most significant problems [3,7,9]. Some degree of gingival enlargement is present in 40% of the children and remains within acceptable limits, with a strict, and regularly reinforced, oral hygiene maintenance program.…”

Section: Discussionmentioning

confidence: 99%

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Four-year follow-up of oral health surveillance in renal transplant children

2006

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To outline the specific oral surveillance needs of renal transplant children, we report the 4-year follow-up data of 106 children examined routinely on a 6-month basis and upon request from the medical team or the parents in the interval. Data were recorded for hard and soft dental tissues, including enamel defects carious lesions, gingival status, orthodontic treatment needs, and wisdom teeth eruption. Hard-tissue lesions were noted in 34.9% of the children, caries lesions on the permanent teeth were seen in 15.0% of cases, 18.86% of the patients had orthodontic treatment. Spontaneous examination, upon request for medical reasons, was given for 26 children. Twenty-one demands originated from the parents. Over a 4-year period the attendance of a dental specialist resulted in a significant improvement in the oral health of the renal transplant children.

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Section: Discussionmentioning

confidence: 99%

“…Characteristics of oral health in transplant children have been described [3][4][5][6]: gingival enlargement related to cyclosporine [7] is the most prevalent problem, and enamel defects are present in a larger proportion than in controls [8]. Fewer results have been reported concerning the need for oral treatment.…”

Section: Introductionmentioning

confidence: 99%

Four-year follow-up of oral health surveillance in renal transplant children

2006

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“…Attention has been paid to local and systemic risk factors such as level of oral hygiene, periodontal conditions, unfavorable anatomical conditions, pretransplant hyperplasia, gingival fibroblast activity and its collagen metabolism, ultrastructural changes in epithelial cells, and genetic predisposition to the human leukocyte antigen phenotype. The connection between the severity and degree of GO, age, gender, CsA total dosage, and CsA trough blood level, treatment duration, and pharmacokinetic properties also has been studied, but the definite cause of this pathology has not been found 1‐13 . It was found that long‐term CsA treatment significantly suppressed the activity of cathepsin‐B and ‐L, consequently decreasing protein degradation in gingival cells 14 .…”

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confidence: 99%

The Relationship of Transforming Growth Factor‐β1 Gene Polymorphism, Its Plasma Level, and Gingival Overgrowth in Renal Transplant Recipients Receiving Different Immunosuppressive Regimens

Radwan-Oczko

Boratyńska

Ziętek

et al. 2006

Journal of Periodontology

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“…Adiyat et al advised against use of the diclofenac patch or diclofenac suppository as single agents during prostate biopsy, but suggested they be used as adjunct treatment (9). No increased incidence of complications in the diclofenac treatment group in comparison to control was found in that study.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Periprostatic Nerve Block and Diclofenac Patch in Transrectal Ultrasound-Guided Prostatic Needle Biopsy

et al. 2012

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BackgroundThe aim of the present study was to compare two analgesic techniques for transrectal ultrasound (TRUS)-guided biopsy: diclofenac patch versus periprostatic nerve block with 1% lidocaine.ObjectivesTo study the efficacy of and compare diclofenac patch and periprostatic nerve block as analgesia in TRUS-guided prostate needle biopsy.Patients and MethodsIn total, 60 patients were prospectively randomized into three groups: those in whom a diclofenac patch was used (n = 20), those in whom periprostatic nerve block was used (n = 20), and a control group (n = 20). Prostate biopsy was performed after administration of analgesia according to group.ResultsThe three groups were similar in terms of age, prostate volume, and PSA (prostate-specific antigen) levels. Pain scores were significantly lower in the nerve block group (P = 0.000) at the time of biopsy until 2 h postprocedure, but not at 4 h postprocedure (P = 0.068). No significant difference in pain score was observed in the diclofenac patch group at the time of biopsy (P = 0.106) as compared to the control group, but the diclofenac patch provided adequate pain relief 1 h (P = 0.000), 2 h (0.000), and 4 h (0.002) postprocedure. No significant difference was observed in pain score between the nerve block (P = 0.520) and control groups (0.057) at probe insertion. The pain score at 4 h was significantly lower in the patch group compared to the nerve block and control groups.ConclusionsPeriprostatic nerve block provides superior analgesia for TRUS-guided biopsy. Diclofenac patch is useful as an adjunct.

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Cyclosporin A‐Induced Gingival Overgrowth in Renal Transplant Patients

Abstract: We conclude that GO induced by CsA may vary according to the individual sensitivity of each patient and may or may not be correlated with other local factors (periodontal variables).

Cited by 35 publications

References 27 publications

Four-year follow-up of oral health surveillance in renal transplant children

Four-year follow-up of oral health surveillance in renal transplant children

The Relationship of Transforming Growth Factor‐β1 Gene Polymorphism, Its Plasma Level, and Gingival Overgrowth in Renal Transplant Recipients Receiving Different Immunosuppressive Regimens

Comparative Evaluation of Periprostatic Nerve Block and Diclofenac Patch in Transrectal Ultrasound-Guided Prostatic Needle Biopsy

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