Cyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinoma

Bayomi, Eman A.; Barakat, Ahmed B.; El-Bassuoni, Maha A.; Talaat, Randa M.; El-Deftar, Mervat M.; Wahab, Sabrin A Abdel; Metwally, Ayman M.

doi:10.4103/0973-1482.147692

Cited by 12 publications

(5 citation statements)

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“…The carcinogenetic effects of COX-2 have been studied in cancers of various organs such as breast, 11 lung, 12 esophagus, 13 head and neck, 14 bladder, 15 and liver. 16 Cyclooxygenase-2 has also been found to be over-expressed in CRC. 7 , 9 , 17 This role of COX-2 in the human malignancies, including CRC was discovered by recent epidemiological studies, which reported an approximately 50% decrease in the relative risk of CRC in individuals using non-steroidal anti-inflammatory drugs; suggesting that these drugs might have protective and therapeutic effects.…”

Section: Discussionmentioning

confidence: 99%

Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients

Albasri

Elkablawy

Hussainy

et al. 2018

SMJ

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Objectives:To evaluate cyclooxygenase-2 (COX-2) over-expression in colorectal cancer (CRC) and its role in carcinogenesis and prognosis.Methods:It was a retrospective study. Archival samples were obtained from Pathology Department at King Fahad Hospital, Madinah, Saudi Arabia, over 11 years’ period (January 2006 to December 2017). Samples were analyzed using immunohistochemistry for COX-2 and Ki67 over-expression in 324 CRC patients, 40 cases of colorectal adenomas and 20 cases of normal colonic mucosa.Results:Cyclooxygenase-2 over-expression was observed in 40% of normal colonic mucosa, 65% of colorectal adenoma and 84.6% of CRC cases. There were no significant correlations between COX-2 over-expression and age, gender, tumor site, or tumor size. However, COX-2 over-expression revealed highly significant correlations with tumor differentiation, lymph node metastasis, lympho-vascular invasion, distant metastasis, advanced stages, and high Ki67 expression. Univariate Kaplan-Meir survival analysis showed that patients with high COX-2 expression had significantly shorter periods of survival. Multivariate analysis by means of the COX-2 regression model revealed that high COX-2 over-expression, AJCC, and Ki67 expression were the only significant independent prognostic indicators.Conclusion:Cyclooxygenase-2 over-expression increases during normal-adenoma-carcinoma sequence, moreover COX-2 over-expression is associated with advanced tumor stage and Ki67 over-expression. These findings suggest a significant role of COX-2 in the carcinogenesis and prognosis of CRC in our study population.

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Section: Discussionmentioning

confidence: 99%

Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients

Albasri

Elkablawy

Hussainy

et al. 2018

SMJ

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“…Prostaglandins synthesized by the cyclooxygenase (COX) pathway, act as mediators of inflammatory and immunological reactions [ 21 ]. Recent studies demonstrated that high expression COX2 are closely related to carcinogenesis[ 41 ]. However, evidence that changes of prostaglandins occur in patients with hepatic cirrhosis remains to be provided.…”

Section: Discussionmentioning

confidence: 99%

Metabolomics and eicosanoid analysis identified serum biomarkers for distinguishing hepatocellular carcinoma from hepatitis B virus-related cirrhosis

et al. 2017

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Hepatocellular carcinoma (HCC) is one of the most common cancers in the world. It is a type of inflammation-related cancer that usually follows liver hepatitis that mostly caused by hepatitis B virus (HBV) in China. However, the metabolism disturbance of HCC and HBV-cirrhosis is not yet fully understood. In addition, there is little research on the relationships between inflammation mediators and HCC. In this study, we investigated serum metabolic abnormalities in HBV-cirrhosis and HCC patients through non-targeted metabolomics and targeted eicosanoid analysis. Metabolomic analysis identified 14 metabolites, i.e. malate, citrate, succinate, lysine, carnitine, proline, ornithine, serine, phenylalanine, tyrosine, arachidonic acid arabinose, galactose and uric acid are consistently altered in HBV-cirrhosis and HCC patients. Meanwhile, eicosanoid analysis uncovered several prostaglandins and leukotrienes are implicated in pathological processes in HBV-cirrhosis and HCC. Finally, these identified biomarkers possessed strong potential to distinguish and diagnose HCC from healthy controls and HBV-cirrhosis patients. This study provided a new perspective to understand the mechanism and discover probable biomarkers of HCC.

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“…Under hepatic pathological conditions, an aberrant activation of β -catenin was evident in chronic inflammation, steatosis, fibrosis, and subsequently tumors of the liver [ 18 , 19 ]. Another “active player”, COX-2, a key protein involved in the inflammation process [ 20 ], had also been suggested to play important roles in the relationship between inflammation and cancer. Studies had shown that the expression of COX-2 in para-carcinoma tissues was higher than that of tumor tissues and was also positively correlated with the degree of differentiation for liver tumor, suggesting a promoting role in the carcinogenesis of early stage [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

Xi-zhen

Zhang

Tang

et al. 2018

Canadian Journal of Gastroenterology and Hepatology

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Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.

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Cyclooxygenase-2 expression is associated with elevated aspartate aminotransferase level in hepatocellular carcinoma

Cited by 12 publications

References 0 publications

Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients

Impact of cyclooxygenase-2 over-expression on the prognosis of colorectal cancer patients

Metabolomics and eicosanoid analysis identified serum biomarkers for distinguishing hepatocellular carcinoma from hepatitis B virus-related cirrhosis

The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

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