Cyclonerol Derivatives from Trichoderma longibrachiatum YM311505

Abstract

A new sesquiterpene, 10,11-dihydrocyclonerotriol (1), together with two known compounds, catenioblin C (2) and sohirnone A (3), were isolated from Trichoderma longibrachiatum YM311505, an endophytic fungus of Azadirachta indica. Their structures were characterized and identified by spectral analysis. Compounds 1-3 exhibited antifungal activities against Pyricularia oryzae and Candida albicans.

Non-Volatile Metabolites from Trichoderma spp.

“…A new sesquiterpene, 10,11-dihydrocyclonerotriol ( 227 ), together with two known compounds, catenioblin C ( 66 ) and sohirnone A ( 228 ), were identified from the endophytic fungus T. longibrachiatum YM311505. Compounds 66 , 227 and 228 exhibited antifungal activities against Pyricularia oryzae and C. albicans [48].…”

A Novel Endophytic Trichoderma longibrachiatum WKA55 With Biologically Active Metabolites for Promoting Germination and Reducing Mycotoxinogenic Fungi of Peanut

“…Trichoderma longibrachiatum is one of the recent studied fungal biocontrol agents, to date, several strains have been reported to generate a diversity of new volatile and nonvolatile metabolites, including peptides, polyketides, and terpenes, which led to the appreciation of T. longibrachiatum as a potential source of unique antibiotics and as talented biocontrol agents against phytopathogenic microorganisms and nematodes (Sridharan et al, 2020(Sridharan et al, , 2021. These metabolites were found to delay the colonization of the pathogens; for instance, the antifungal secondary metabolites of T. longibrachiatum were reported against Candida albicans and Pyricularia oryzae (Xuan et al, 2014). Further, the secondary metabolites were found to induce disease resistance and regulate plant growth (Khan et al, 2020).…”

Trichoderma species from plant and soil: An excellent resource for biosynthesis of terpenoids with versatile bioactivities

“… Type No. Names Sources Reference Cyclonerane-type sesquiterpenes 1 cyclonerodiol Trichoderma polysporum [34] 2 cyclonerodiol oxide Trichoderma polysporum [34] 3 epicyclonerodiol oxide Trichoderma polysporum [34] 4 cyclonerotriol Trichoderma virens [35] 5 10,11-dihydrocyclonerotriol Trichoderma longibrachiatum YM311505 [36] 6 cyclonerodiol B Trichoderma sp. Xy24 [37] 7 (10 E )-12-acetoxy-10-cycloneren-3,7-diol Trichoderma harzianum P 1-4 [38] 8 12-acetoxycycloneran-3,7-diol Trichoderma harzianum P 1-4 [38] 9 9-cycloneren-3,7,11-triol Trichoderma asperellum cf44-2 [39] 10 11-cycloneren-3,7,10-triol Trichoderma asperellum cf44-2 [39] 11 7,10-epoxycycloneran-3,11,12-triol Trichoderma asperellum cf44-2 [39] 12 11-methoxy-9-cycloneren-3,7-diol Trichoderma harzianum X-5 [40] 13 10-cycloneren-3,5,7-triol Trichoderma harzianum X-5 [40] 14 methyl 3,7-dihydroxy-15-cycloneranate Trichoderma harzianum X-5 [40] 15 3,7,11-trihydroxycycloneran-10-one …”