Trichoderma species from plant and soil: An excellent resource for biosynthesis of terpenoids with versatile bioactivities

Structures and Biological Activities of Secondary Metabolites from the Trichoderma genus (Covering 2018–2022)

“…are peptaibols, which are characterized by their chain length of 5−20 amino acid residues and possess distinctive structural features such as an acylated N-terminus, a C-terminal amino alcohol, and a high content of 2-aminoisobutyric acid (Aib). 41 Hyporientalin A (216), a longsequence peptaibol, was isolated from marine T. orientale strain LSBA1 and displayed inhibitory activity against growth of Gram-positive and Gram-negative bacteria as well as clinical In addition, a marine-derived fungus Trichoderma sp. was found to produce a series of novel 15-residue peptaibols called pentadecaibins I−V (238−242), which were characterized by the lack of the widespread Aib-Pro motif.…”

“…The majority of peptide SMs from Trichoderma spp. are peptaibols, which are characterized by their chain length of 5–20 amino acid residues and possess distinctive structural features such as an acylated N-terminus, a C-terminal amino alcohol, and a high content of 2-amino-isobutyric acid (Aib) . Hyporientalin A ( 216 ), a long-sequence peptaibol, was isolated from marine T.…”

“…Trichoderma species are considered a rich source of distinctive bioactive metabolites due to the presence of numerous biosynthetic gene clusters that enable them to adapt to different ecological biotopes . Several excellent reviews have published research advances regarding the SMs derived from the genus Trichoderma. − In 2008, Reino et al conducted a review on the structural and biological studies of the metabolites isolated from Trichoderma species prior to 2007 . In 2018, Su et al summarized the structures and bioactivities of 78 metabolites documented from marine species within the Trichoderma genus .…”

“…against phytopathogenic fungi . Recently, Bai, Guo, et al reviewed the terpenoids of Trichoderma and the SMs of Trichoderma harzianum, respectively. , Furthermore, there has been a remarkable increase in reports of novel SMs from Trichoderma species over the past five years. Therefore, in the present review, we conducted a detailed and comprehensive literature survey on the newly reported natural products from the Trichoderma genus, encompassing their structural diversities, biological activities, and structure–activity relationships (SARs) over the past five years (2018–2022).…”

Biological activity of some Romanian and Turkish Trichoderma Pers. strains

“…(Hypocreales, Ascomycota) is a genus of filamentous fungi that have a symbiotic relationship with plants, and can also grow as saprobes (Ferreira & Musumeci 2021). These fungi are found in a variety of habitats, including soil, water, decaying wood, agricultural areas, plants, air, and dust (Bai et al 2023). The genus is comprised of around 466 different species, identified based on their morphological features.…”