Cyclohexyl Isocyanide

Ugi, Ivar; Meyr, Rudolf; Lipiński, M.; Bodesheim, Ferdinand; Rosendahl, Friedrich Karl

doi:10.1002/0471264180.os041.04

Cited by 14 publications

(15 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…β-pinene analogues were evaluated for herbicidal activity of the representative monocotyledonous weed E. crus-galli and the dicotyledonous weeds A. retroflexus and B. campestris L. The herbs were grown in a greenhouse and the test method was the conventional plate method (in vitro) [ 25 , 26 , 27 ]. In the evaluation, all of the test compounds were dissolved in mixed solution of DMF and distilled water ( v / v = 8:1).…”

Section: Methodsmentioning

confidence: 99%

High Add Valued Application of Turpentine in Crop Production through Structural Modification and QSAR Analysis

Gao

et al. 2018

Molecules

View full text Add to dashboard Cite

Turpentine is a volatile component of resin, which is an abundant forest resource in Southern China. As one of the most important components, the integrated application of β-pinene has been studied. The broad-spectrum evaluation of β-pinene and its analogues has, therefore, been necessary. In an attempt to expand the scope of agro-activity trials, the preparation and the evaluation of the herbicidal activity of a series of β-pinene analogues against three agricultural herbs were carried out. In accordance with the overall herbicidal activity, it is noteworthy that compounds 6k, 6l, and 6m demonstrated extreme activity with IC50 values of 0.065, 0.065, and 0.052 mol active ingredients/hectare against E. crus-galli. The preliminary structure–activity relationship (SAR) was analyzed and the compounds with the appropriate volatility and substituent type that had beneficial herbicidal activity were analyzed. Simultaneously, the quantitative structure–activity relationship (QSAR) model was built and the most important structural features were indicated, which was, to a certain extent, in line with the SAR study. The study aimed to study the application of the forest resource turpentine in agriculture as a potential and alternative approach for comprehensive utilization.

show abstract

Section: Methodsmentioning

confidence: 99%

High Add Valued Application of Turpentine in Crop Production through Structural Modification and QSAR Analysis

Gao

et al. 2018

Molecules

View full text Add to dashboard Cite

show abstract

“…Cyclohexyl isocyanide (5a), 10,11 n-hexyl isocyanide (5b), 12 4-methylphenyl isocyanide (5c), 13 and arylglyoxals 7a, 14 7b, 15 7c, 15 , 7d 15 were prepared according to literature procedures. Mps were determined in open capillary tubes using a Büchi 512 melting point apparatus and are uncorrected.…”

Section: Methodsmentioning

confidence: 99%

Studies on Isocyanides and RelatedCompounds: A Facile Synthesis of 1,6-Dihydro-6-oxopyrazine-2-carboxylicAcid Derivatives via Ugi Four-Component Condensation

Faggi¹,

Garcı́a-Valverde²,

Marcaccini³

et al. 2003

Synthesis

View full text Add to dashboard Cite

The Ugi four-component condensation (U-4CC) between arylglyoxals 7, amines 6, benzoylformic acid (4) and isocyanides 5 afforded the expected products 8 which were cyclized in a 5+1 fashion with ammonium acetate to give 1,N-disubstituted 4aryl-1,6-dihydro-6-oxo-5-phenylpyrazine-2-carboxamides 9 in good yields. Evidence for the assigned structures 9 was provided by 13 C NMR spectra and X-ray analysis of 9a.

show abstract

“…Hydrolysis, alcoholysis and aminolysis of isocyanates lead respectively to amines, carbamates and ureas . Importantly, the treatment of formamides with a dehydrating agent (POCl 3 , SOCl 2 , COCl 2 ) and the carbylamine reaction (amine, CHCl 3 , NaOH) are still useful synthetic procedures to prepare isocyanides …”

Section: Isocyanides: Take Home Key Factsmentioning

confidence: 99%

Biosynthetic Routes to Natural Isocyanides

2020

View full text Add to dashboard Cite

As intriguing as it may appear, natural products bearing an isocyanide function are well known in different kingdoms of living organisms. An important question in terms of biochemistry is, of course, the origin of such a functional group and the mechanisms that have evolved in biosynthetic pathways to afford the formation of isocyanides. The latest studies dedicated to such endeavours are analysed therein in view of the producing organism metabolisms (e.g. micro‐organisms, marine invertebrates). The in‐situ reactivity of natural isocyanides is also discussed as well as their biological activities.

show abstract

Cyclohexyl Isocyanide

Abstract: Cyclohexyl isocyanide reactant: 127 g. (1.00 mole) of N‐cyclohexylformamide solvent: 300 ml. of petroleum ether product: Cyclohexyl isocyanide product: isopropyl product: n ‐butyl … Show more

Cited by 14 publications

References 3 publications

High Add Valued Application of Turpentine in Crop Production through Structural Modification and QSAR Analysis

High Add Valued Application of Turpentine in Crop Production through Structural Modification and QSAR Analysis

Studies on Isocyanides and RelatedCompounds: A Facile Synthesis of 1,6-Dihydro-6-oxopyrazine-2-carboxylicAcid Derivatives via Ugi Four-Component Condensation

Biosynthetic Routes to Natural Isocyanides

Contact Info

Product

Resources

About