Cyclodextrin Complex Osmotic Tablet for Glipizide Delivery

Gan, Yong; Pan, Weisan; Wei, Mingchun; Zhang, Ruhua

doi:10.1081/ddc-120006432

Cited by 23 publications

(9 citation statements)

References 9 publications

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“…The granules were passed through sieve 22 and obtained uniform sized granules were mixed with GZ-SD with blending of magnesium stearate and talc (all 60-mesh passed). [23][24][25][26] The resultant homogenized mixture were compressed into tablets having an average weight of 400 mg using a multistation rotary machine (CIP-Ahmadabad, D-8, India) fitted with 10 mm round standard concave punches [ Table 1].…”

Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Untitled

Payghan

2016

AJP

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Aim: Glipizide (GZ) which is oral hypoglycemic drug belongs to BCS Class II was selected as a model drug to prepare controlled porosity osmotic pump (CPOP) tablet. Materials and Methods: The solubility of GZ was increased by forming its solid dispersion (SD) with polyvinylpyrrolidone (PVP). The GZ-PVP SD (GZ-SD) systems were prepared by physical mixing and spray drying method, and characterized by differential scanning calorimetry, powder X-ray diffraction analysis, Fourier transform-infrared spectroscopy, and scanning electron microscopy (SEM). Results and Discussion: The effect of different formulation variables-such as the level of solubility modifier in the core, membrane weight gain, and level of pore former in the membrane-were studied. Drug release was found to be affected by the level of solubility modifier present in the core. GZ release was inversely proportional to the membrane weight but directly related to the initial level of pore former (PVP, sorbitol) in the membrane. Drug release from the developed formulations was independent of pH and agitational intensity, but dependent on the osmotic pressure of the dissolution media. Conclusion: Results of SEM studies confirmed the formation of pores in the membrane from where the drug release occurred. The formulations were stable after 3 months of accelerated stability studies. The results indicated that CPOP tablet developed using spray dried GZ-SD had excellent zero-order release characteristics in vitro.

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Section: Scanning Electron Microscopy (Sem)mentioning

confidence: 99%

Untitled

Payghan

2016

AJP

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“…The API is added to this slurry as either a solid or a predissolved aqueous solution and the components are mixed. Gan et al8 studied the effect of kneading time on complex formation and found that, for a glipizide/β‐cyclodextrin system, continued mixing after 2 h did not further affect the inclusion complex yield. This work was done at small scale with a mortar and pestle.…”

Section: Preparation Of Solid Inclusion Complexesmentioning

confidence: 99%

“…This could be to enhance stability,3 as a taste mask, as a manufacturing process aid (filler, binder, channeling agent, etc. ),4 as an osmogen in controlled release pump dosage forms,5–8 and to increase dissolution with the goal of increasing absorption. There is extensive coverage of cyclodextrin technology in the literature.…”

Section: Introductionmentioning

confidence: 99%

Practical considerations in development of solid dosage forms that contain cyclodextrin

Miller

Ahmed

2007

Journal of Pharmaceutical Sciences

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“…MT is highly soluble and high dose (500 mg) while GZ is water insoluble and low dose (5 mg). Gan et al (2002) developed a cyclodextrin complex osmotic tablet for GZ. However, it needed a complicated process and the amount of excipient was very high.…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets

Ouyang

Nie

et al. 2005

Journal of Pharmacy and Pharmacology

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A simple elementary osmotic pump (EOP) system that could deliver metformin hydrochloride (MT) and glipizide (GZ) simultaneously for extended periods of time was developed in order to reduce the problems associated with multidrug therapy of type 2 non-insulin-dependent diabetes mellitus. In general, both highly and poorly water-soluble drugs are not good candidates for elementary osmotic delivery. However, MT is a highly soluble drug with a high dose (500 mg) while GZ is a water-insoluble drug with a low dose (5 mg) so it is a great challenge to pharmacists to provide satisfactory extended release of MT and GZ. In this paper sodium carbonate was used to modulate the solubility of GZ within the core and MT was not only one of the active ingredients but also the osmotic agent. The optimal EOP was found to deliver both drugs at a rate of approximately zero order for up to 10 h in pH 6.8, independent of environment media. In-vivo evaluation was performed relative to the equivalent dose of conventional MT tablet and GZ tablet by a cross-study in six Beagle dogs. The EOP had a good sustained effect in comparison with the conventional product. The prototype design of the system could be applied to other combinations of drugs used for cardiovascular diseases, diabetes, etc.

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Cyclodextrin Complex Osmotic Tablet for Glipizide Delivery

Cited by 23 publications

References 9 publications

Untitled

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Practical considerations in development of solid dosage forms that contain cyclodextrin

Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets

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