Cyclocarya paliurus (Batalin) Iljinskaja: Botany, Ethnopharmacology, phytochemistry and pharmacology

Chen, Zhuliang; Jian, Yuqing; Wu, Qian; Wu, Jia; Sheng, Wen‐Bing; Jiang, Sai; Shehla, Nuzhat; Aman, Shumaila; Wang, Wei

doi:10.1016/j.jep.2021.114912

Cited by 23 publications

(16 citation statements)

References 69 publications

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“…The total triterpenoid content of C. paliurus has also been shown to ameliorate glucose and lipid metabolism disorders [ 20 ]. A total of 137 triterpenoids are found in C. paliurus leaves [ 10 ], as described in Table 2 , many of which promote glucose uptake [ 21 , 44 , 45 ] and improve lipid metabolism [ 46 , 47 ].…”

Section: Active Components Of C Paliurusmentioning

confidence: 99%

“…Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes enrichment analysis showed that these genes are involved in polyketone biosynthesis, amino acid and nucleotide metabolism, and starch and sucrose metabolism [ 9 ]. C. paliurus contains various active ingredients, such as polysaccharides, triterpenes, flavonoids, and phenolic acids, present mainly in the leaves [ 10 ]. Our study revealed that the contents of polysaccharides, triterpenes, flavonoids, and phenolic acids in C. paliurus leaves differed in different months.…”

Section: Introductionmentioning

confidence: 99%

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Progress in Research on the Alleviation of Glucose Metabolism Disorders in Type 2 Diabetes Using Cyclocarya paliurus

et al. 2022

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Globally, the incidence of diabetes is increasing annually, and China has the largest number of patients with diabetes. Patients with type 2 diabetes need lifelong medication, with severe cases requiring surgery. Diabetes treatment may cause complications, side-effects, and postoperative sequelae that could lead to adverse health problems and significant social and economic burdens; thus, more efficient hypoglycemic drugs have become a research hotspot. Glucose metabolism disorders can promote diabetes, a systemic metabolic disease that impairs the function of other organs, including the heart, liver, and kidneys. Cyclocarya paliurus leaves have gathered increasing interest among researchers because of their effectiveness in ameliorating glucose metabolism disorders. At present, various compounds have been isolated from C. paliurus, and the main active components include polysaccharides, triterpenes, flavonoids, and phenolic acids. C. paliurus mainly ameliorates glucose metabolism disorders by reducing glucose uptake, regulating blood lipid levels, regulating the insulin signaling pathway, reducing β-cell apoptosis, increasing insulin synthesis and secretion, regulating abundances of intestinal microorganisms, and exhibiting α-glucosidase inhibitor activity. In this paper, the mechanism of glucose metabolism regulation by C. paliurus was reviewed to provide a reference to prevent and treat diabetes, hyperlipidaemia, obesity, and other metabolic diseases.

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Section: Active Components Of C Paliurusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Progress in Research on the Alleviation of Glucose Metabolism Disorders in Type 2 Diabetes Using Cyclocarya paliurus

et al. 2022

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“…Experimental studies have shown that extracts and constituents of CP have pharmacological activities such as antitumor, anti-inflammatory, antioxidant, immunomodulatory, and hypolipidemic. 35,36 In recent years, CP has attracted much attention as a functional food raw material with a hypoglycemic effect, and its extract has been reported to be active against diabetic nephropathy and diabetic cardiomyopathy. [37][38][39] Zhang and associates analyzed the anti-DR activity of arjunolic acid (AA) from CP in vivo and in vitro.…”

Section: Cyclocarya Paliurus (Batalin) Iljinskmentioning

confidence: 99%

Progress in Traditional Chinese Medicine on Treatment of Diabetic Retinopathy

Xing

et al. 2022

Natural Product Communications

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Diabetic retinopathy (DR), a common and blinding diabetic microvascular complication, is a harmful metabolic effect caused by persistent hyperglycemia. Owing to the complex pathogenesis of DR, various clinical treatment methods cannot completely prevent its development and are accompanied by various complications. Therefore, there is an urgent need to identify new therapeutic drugs or complementary and alternative therapies. Traditional Chinese medicine (TCM) has the unique advantages of multi-level, multi-target, and minimal side effects. Accumulating evidence has proven that TCM may help delay or prevent the progression of DR. This paper reviews the effect and mechanism of representative TCMs (including extracts, identified compounds, and compound formulas) on DR in recent years and provides evidence for new drug development and clinical efficacy.

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“…Cyclocarya paliurus, an endemic plant that grows in southern China, has been widely used as an herbal tea and is commonly known as the 'sweet tea tree'. The leaves of this plant have been used in Chinese folk medicine to prevent diabetes, hypertension, inflammation, and heart disease [9,10]. There have been many reports on the significant antidiabetic effects of the extract of C. paliurus leaves [11][12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Currently, C. paliurus is a crop for rural revitalization and an important medical and functional raw food. A variety of triterpenoids, flavonoids, and other compounds can be isolated from the leaves of this plant [9,10]. Among these constituents, dammarane triterpenoids are characteristic indicators and the key functional and active constituents of C. paliurus [9,10,21,22].…”

Section: Introductionmentioning

confidence: 99%

Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes

et al. 2023

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Four new dammarane triterpenoid saponins cypaliurusides Z1–Z4 (1–4) and eight known analogs (5–12) were isolated from the leaves of Cyclocarya paliurus. The structures of the isolated compounds were determined using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. The docking study demonstrated that compound 10 strongly bonded with PTP1B (a potential drug target for the treatment of type-II diabetes and obesity), hydrogen bonds, and hydrophobic interactions, verifying the importance of sugar unit. The effects of the isolates on insulin-stimulated glucose uptake in 3T3-L1 adipocytes were evaluated and three dammarane triterpenoid saponins (6, 7 and 10) were found to enhance insulin-stimulated glucose uptake in 3T3-L1 adipocytes. Furthermore, compounds 6, 7, and 10 exhibited potent abilities to promote insulin-stimulated glucose uptake in 3T3-L1 adipocytes in a dose-dependent manner. Thus, the abundant dammarane triterpenoid saponins from C. paliurus leaves exhibited stimulatory effects on glucose uptake with application potential as a antidiabetic treatment.

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Cyclocarya paliurus (Batalin) Iljinskaja: Botany, Ethnopharmacology, phytochemistry and pharmacology

Cited by 23 publications

References 69 publications

Progress in Research on the Alleviation of Glucose Metabolism Disorders in Type 2 Diabetes Using Cyclocarya paliurus

Progress in Research on the Alleviation of Glucose Metabolism Disorders in Type 2 Diabetes Using Cyclocarya paliurus

Progress in Traditional Chinese Medicine on Treatment of Diabetic Retinopathy

Triterpenoids from the Leaves of Cyclocarya paliurus and Their Glucose Uptake Activity in 3T3-L1 Adipocytes

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