Cyclin‐Dependent Protein Kinases in the Control of Cell Cycle in Plants

Harashima, Hirofumi; Sekine, Masami

doi:10.1002/9781119541578.ch14

Cited by 6 publications

(9 citation statements)

References 128 publications

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“…These regulations can be classified as acting at the cellular and organ level. At the cellular level , a plant cell undergoes several rounds of the mitotic cell cycles, through multiple, sequentially ordered phases leading to the generation of two genetically identical daughter cells ( Dewitte and Murray, 2003 ; Francis, 2007 ; Harashima and Sekine, 2020 ). Multiple cell-cycle related transcriptional regulators have been identified that control these processes.…”

Section: Fruit Growthmentioning

confidence: 99%

Fruit growth and development in apple: a molecular, genomics and epigenetics perspective

Jahed

Hirst

2023

Front. Plant Sci.

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Fruit growth and development are physiological processes controlled by several internal and external factors. This complex regulatory mechanism comprises a series of events occurring in a chronological order over a growing season. Understanding the underlying mechanism of fruit development events, however, requires consideration of the events occurring prior to fruit development such as flowering, pollination, fertilization, and fruit set. Such events are interrelated and occur in a sequential order. Recent advances in high-throughput sequencing technology in conjunction with improved statistical and computational methods have empowered science to identify some of the major molecular components and mechanisms involved in the regulation of fruit growth and have supplied encouraging successes in associating genotypic differentiation with phenotypic observations. As a result, multiple approaches have been developed to dissect such complex regulatory machinery and understand the genetic basis controlling these processes. These methods include transcriptomic analysis, quantitative trait loci (QTLs) mapping, whole-genome approach, and epigenetics analyses. This review offers a comprehensive overview of the molecular, genomic and epigenetics perspective of apple fruit growth and development that defines the final fruit size and provides a detailed analysis of the mechanisms by which fruit growth and development are controlled. Though the main emphasis of this article is on the molecular, genomic and epigenetics aspects of fruit growth and development, we will also deliver a brief overview on events occurring prior to fruit growth.

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Section: Fruit Growthmentioning

confidence: 99%

Fruit growth and development in apple: a molecular, genomics and epigenetics perspective

Jahed

Hirst

2023

Front. Plant Sci.

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“…CYCs and CDKs form complexes that phosphorylate various target proteins at specific phases of the cell cycle, namely G1 (gap 1), S (synthesis), G2 (gap 2), and M (mitosis). Among CDKs, B-type CDKs (CDKBs) are plantspecific and are thought to be solely associated with cell cycle regulation 41 . CDKBs comprise two subgroups, CDKB1 and CDKB2, each represented by two members (CDKB1;1, CDKB1;2, CDKB2;1 and CDKB2;2).…”

Section: Mainmentioning

confidence: 99%

“…Cell differentiation programs are tightly linked to cell cycle regulation to establish tissues and organs 40 . Cell cycle progression is driven mainly by the interaction of cyclins (CYCs) and cyclin-dependent kinases (CDKs), a class of Ser/Thr kinases 41 . CYCs and CDKs form complexes that phosphorylate various target proteins at specific phases of the cell cycle, namely G1 (gap 1), S (synthesis), G2 (gap 2), and M (mitosis).…”

Section: Mainmentioning

confidence: 99%

“…CDKB activity is a marker for G2/M progression. The action of CYC/CDK complexes can be regulated by CYC/CDK inhibitors (CKIs) 41,42 , which may belong to one of two families: INTERACTOR/INHIBITOR OF CDK/KIP-RELATED PROTEINs (ICK/KRPs) and SIAMESE-RELATED PROTEINs (SMRs). ICK/KRPs are encoded by seven genes in Arabidopsis, KRP1 (ICK1), KRP2 (ICK2), KRP3 (ICK6), KRP4 (ICK7), KRP5 (ICK3), KRP6 (ICK4), and KRP7 (ICK5), which are distantly related to CKI p27 Kip1 , a member of the mammalian Kip/Cip CKI family 43 .…”

Section: Mainmentioning

confidence: 99%

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A histone modification-based synthetic circuit to engineer temporal gene expression in Arabidopsis floral meristems

Pelayo

Sawada

Matsushita

et al. 2022

Preprint

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The termination of floral meristems is regulated by the MADS domain transcription factor AGAMOUS (AG) by passively diluting the H3K27me3 mark along the KNUCKLES (KNU) coding sequence. How many other downstream genes are similarly regulated by this intrinsic epigenetic timer and whether it can be harnessed for engineering synthetic circuits are unknown. Here, we describe a biotimer gene regulatory network downstream of AG and manipulate the timing of KNU expression through a synthetic system. We manipulated temporal gene expression using the del region from the KNU coding sequence, which is decorated by H3K27me3-marked nucleosomes. Increasing the number of del copies delayed and reduced KNU expression in a PRC2- and cell cycle-dependent manner. We propose that PRC2 deposits H3K27me3, while cell divisions dilute H3K27me3 accumulation on the extended KNU coding sequence. Our results shed light on temporal transitions governing flower development and provide a novel tool for tunable gene expression.

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“…Within the set of stress-responsive genes, cdc2a, a homolog of cyclin-dependent protein kinase (CDK), plays a crucial role in regulating the cell cycle (Campo et al, 2014;Harashima and Sekine, 2020). In response to signaling cascades that perceive stress, cdc2a triggers cell division as a means of repairing, adapting, and enhancing the tolerance of plant tissues (Kim et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Ca++ particle films on sweet potato plants: Repression of the cdc2a gene and alterations in leaf anatomy under photo-protection

Ferreira

Oliveira

Júnior

et al. 2023

Preprint

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Water restriction combined with strong sunlight can affect the growth and development of crops. Activation of potential stress-associated genes and specific changes in leaf structure can be critical adaptive responses in controlling unfavorable climatic conditions. This work evaluated the expression of the cdc2a gene and leaf anatomical alterations in sweet potato plants photo-protected with Calcium particle film with and without water restriction. Assessments were performed at 12:00, focusing on gas exchange, temperature (air-leaf), Falker index, chlorophyll a fluorescence, gene expression (cdc2a), and leaf anatomy. The protection of plants regarding gas exchange contributed to the potential increase in photosynthetic rate (A) and a more significant difference between air and leaf temperatures (Dif ºC), as positive responses in the adaptive adjustment. There was a reduction in the fluorescence of chlorophyll a, related to the maximum cross-section ABS/CSm, TR0/CSm, RE0/CSm, ET0/CSm, DI0/CSm, and a significant increase in the effective quantum yield (ɸPSII), transport rate (ETR), maximum quantum yield (Fv/Fm), and photochemical quenching (qP). There was the repression of the cdc2a gene, allied to the physiological responses associated with light-intensity stress. Anatomical changes related to climate adaptation occurred for the treatments; and photoprotection with CaO minimized the deleterious effects during the development of sweet potato plants, mainly in the developmental stage of roots.

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Cyclin‐Dependent Protein Kinases in the Control of Cell Cycle in Plants

Cited by 6 publications

References 128 publications

Fruit growth and development in apple: a molecular, genomics and epigenetics perspective

Fruit growth and development in apple: a molecular, genomics and epigenetics perspective

A histone modification-based synthetic circuit to engineer temporal gene expression in Arabidopsis floral meristems

Ca++ particle films on sweet potato plants: Repression of the cdc2a gene and alterations in leaf anatomy under photo-protection

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