Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma

Casson, Alan G.; Zheng, Zuoyu; Evans, Susan C.; Geldenhuys, Laurette; Zanten, Sander Veldhuyzen van; Veugelers, Paul J.; Porter, Geoffrey A.; Guernsey, Duane L.

doi:10.1002/cncr.21229

Cited by 55 publications

(42 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cyclin D1 (CCND1) G870A polymorphism has been known to be a risk factor in multiple cancers [59][60][61][62][63] . However, investigations concerning the association of CCND1 G870A polymorphism with esophageal cancer risk have generated conflicting results [64][65][66][67][68][69] . The overall data suggest that CCND1 G870A variations might have an association with increased esophageal cancer susceptibility.…”

Section: Zhang Y Risk Factors Of Esophageal Cancermentioning

confidence: 99%

Epidemiology of esophageal cancer

Zhang¹

2013

WJG

891

749

View full text Add to dashboard Cite

Esophageal cancer (EsC) is one of the least studied and deadliest cancers worldwide because of its extremely aggressive nature and poor survival rate. It ranks sixth among all cancers in mortality. In retrospective studies of EsC, smoking, hot tea drinking, red meat consumption, poor oral health, low intake of fresh fruit and vegetables, and low socioeconomic status have been associated with a higher risk of esophageal squamous cell carcinoma. Barrett's esophagus is clearly recognized as a risk factor for EsC, and dysplasia remains the only factor useful for identifying patients at increased risk, for the development of esophageal adenocarcinoma in clinical practice. Here, we investigated the epidemiologic patterns and causes of EsC. Using population based cancer data from the Surveillance, Epidemiology and End Results Program of the United States; we generated the most up-to-date stage distribution and 5-year relative survival by stage at diagnosis for 1998-2009. Special note should be given to the fact that esophageal cancer, mainly adenocarcinoma, is one of the very few cancers that is contributing to increasing death rates (20%) among males in the United States. To further explore the mechanism of development of EsC will hopefully decrease the incidence of EsC and improve outcomes.© 2013 Baishideng. All rights reserved.Key words: Risk factor; Barrett's esophagus; Cyclin D1 G870A; Esophageal neoplasm; Susceptibility; Polymorphism Core tip: Here, we investigated the epidemiologic patterns and causes of esophageal cancer. Using population based cancer data from the Surveillance, Epidemiology and End Results Program of the United States; we generated the most up-to-date stage distribution and 5-year relative survival by stage at diagnosis for

show abstract

Section: Zhang Y Risk Factors Of Esophageal Cancermentioning

confidence: 99%

Epidemiology of esophageal cancer

Zhang¹

2013

WJG

891

749

View full text Add to dashboard Cite

show abstract

“…If more than 1 geographical or ethnic group was included in the same study, then data from different populations were extracted. Therefore, 8 studies, including 9 populations (Yu et al, 2003;Zhang et al, 2003;Casson et al, 2005;Geddert et al, 2005;Jain et al, 2007;Akbari et al, 2009;Liu et al, 2010;Hussain et al, 2011) with 1898 patients with esophageal cancer and 3046 controls were finally identified: 4 populations were from East Asia [2 Chinese (Yu et al, 2003;Zhang et al, 2003) and 2 from India (Jain et al, 2007;Hussain et al, 2011)], 2 were from West Asia (Akbari et al, 2009), and 3 included Caucasians (Casson et al, 2005;Geddert et al, 2005;Liu et al, 2010). A flow diagram schematizing the process of selected and excluded articles with specific reasons for each is presented in Figure 1.…”

Section: Baseline Characteristicsmentioning

confidence: 99%

“…A flow diagram schematizing the process of selected and excluded articles with specific reasons for each is presented in Figure 1. With regard to the study design, 3 of these studies were population based (Yu et al, 2003;Zhang et al, 2003;Akbari et al, 2009), and 5 employed a hospital-based design (Casson et al, 2005;Geddert et al, 2005;Jain et al, 2007;Liu et al, 2010;Hussain et al, 2011 …”

Section: Baseline Characteristicsmentioning

confidence: 99%

Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis

Cai

Wang²,

Zhong³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. The association between the Cyclin D1 gene (CCND1) G870A polymorphism and esophageal cancer has been widely evaluated, with conflicting results. As meta-analysis is a reliable approach to resolving discrepancies, we aimed to evaluate this association. Data were available from 9 study populations incorporating 1898 cases and 3046 controls. Overall, the allelic/genotypic association between the G870A polymorphism and esophageal cancer was nonsignificant [for allele: odds ratio (OR) = 1.14, 95% confidence interval (95%CI) = 0.94-1.38, P = 0.184; for genotype homozygous comparison: OR = 1.36, 95%CI = 0.90-2.06, P = 0.140; for dominant model: OR = 1.24, 95%CI = 0.88-1.75, P = 0.222; for recessive model: OR = 1.13, 95%CI = 0.90-1.43, P = 0.292]. Moreover, subgroup analyses according to study designs, geographic areas, types of esophageal cancer, genotyping methods, and ethnicities failed to demonstrate a significant association between this polymorphism and esophageal cancer. In addition, there was significant publication bias as reflected by funnel plots and the 6637 CCND1 G870A and esophageal cancer ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 6636-6645 (2013) Egger test (P = 0.042). Taken together, our results suggest that the CCND1 G870A polymorphism might not be a potential candidate for predicting esophageal cancer risk.

show abstract

“…Casson et al (15), Jain et al (17) and Hussain et al (19) showed a significant association between this polymorphism and esophageal cancer. However, four other studies demonstrated no significant association between this polymorphism and esophageal cancer (13,14,16,18).…”

Section: Resultsmentioning

confidence: 94%

“…The full text of these articles was reviewed intensively and three articles without the control group were excluded. Thus, seven case-control studies (1,154 esophageal cancer cases and 1,678 controls) on the association between CCND1 G870 polymorphism and esophageal cancer risk were included in this meta-analysis (13)(14)(15)(16)(17)(18)(19). Of these included articles, four studies were on Caucasians (15,16,18,19) and three studies were on Asians (13,14,17).…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphism of CCND1 G870A and esophageal cancer susceptibility: A meta-analysis

Zeng

Long

et al. 2012

Biomedical Reports

View full text Add to dashboard Cite

Abstract. The association between the polymorphism of cyclin D1 (CCND1) and esophageal carcinogenicity has been widely examined, however, it remains controversial. To evaluate the importance of CCND1 G870A polymorphism with regard to the risk of esophageal cancer, a meta-analysis was carried out that reviewed the available literature in order to clarify the controversies. This meta-analysis included 1,154 cases and 1,678 controls for CCND1 G870A polymorphism from seven published case-control studies. The odds ratio (OR) and 95% confidence interval (CI) were calculated using the Stata software version 11.1. The results were pooled using a dominant model to appropriately reflect a biological model of the genetic effect. No significant association was observed in the Caucasian (OR=1.64; 95% CI, 0.84-3.20) or the Asian populations (OR=1.30; 95% CI, 0.65-2.62), while no significant association was found in esophageal squamous cell carcinoma (ESCC) (OR=1.74; 95% CI, 0.79-3.81) or esophageal adenocarcinoma (EADC) (OR=1.18; 95% CI, 0.77-1.81). However, the comparison of A vs. G in CCND1 G870A showed significant differential susceptibility to esophageal cancer (OR=1.26; 95% CI, 1.00-1.59). These findings suggested that the CCND1 G870A polymorphism has no association with esophageal cancer risk in ethnicity and histology, respectively. Further studies are required to assess these associations in greater detail. IntroductionEsophageal cancer is a global health problem that ranked eighth in terms of incidence and sixth in terms of mortality in 2002 (1). Esophageal tumors usually lead to dysphagia, pain and other symptoms and are diagnosed via a biopsy. Esophageal cancer is divided into squamous cell carcinoma and adenocarcinoma. Squamous cell carcinoma arises from the cells that line the upper part of the esophagus. Adenocarcinoma arises from glandular cells that are present at the junction of the esophagus and stomach (2). Genetic as well as environmental factors play a role in the carcinogenesis of esophageal cancer (3,4). Individual variations in cancer risk have been associated with specific polymorphisms of various genes that are present in a significant proportion of the normal population.Cyclin D1 (CCND1) is a mitogenic sensor for the cell cycle mechanism and cellular oncogene (5). High activity of cyclin D1 can lead to chemoresistance due to the dual roles of cyclin D1 in promoting cell proliferation and inhibiting drug-induced apoptosis (6). Overexpression of cyclin D1 contributes to immature cell passage through the G1-S transition, induces propagation of unrepaired DNA damage and the accumulation of genetic errors and a selective growth advantage for the altered cells (7). Cyclin D1 are important regulators of the cell cycle and apoptosis and each contains functional single nucleotide polymorphisms (SNPs) (CCND1 G870A) that are involved in the susceptibility and outcome of various human malignancies (8).Poor statistical power has been controversial for data from individually published studies. The aim of this stu...

show abstract

Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma

Cited by 55 publications

References 42 publications

Epidemiology of esophageal cancer

Epidemiology of esophageal cancer

Lack of association between Cyclin D1 gene G870A polymorphism and esophageal cancer: evidence from a meta-analysis

Genetic polymorphism of CCND1 G870A and esophageal cancer susceptibility: A meta-analysis

Contact Info

Product

Resources

About