Cyanidin-3-glucoside attenuates high-fat and high-fructose diet-induced obesity by promoting the thermogenic capacity of brown adipose tissue

You, Yilin; Han, Xue; Guo, Jielong; Guo, Yu; Yin, Manwen; Liu, Guojie; Huang, Weidong; Zhan, Jicheng

doi:10.1016/j.jff.2017.12.025

Cited by 51 publications

(44 citation statements)

References 63 publications

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“…The dose of GE used in this study has reference significance for the dietary intake of humans. The previous studies have demonstrated that dietary supplementation with C3G, [ 8,17 ] rutin, and VA [ 6 ] could prevent obesity in mice induced by an HFFD. Moreover, 1% w/w of C3G dissolved in drinking water, which was higher than the daily intake of the polyphenol monomer, could reduce the BW of mice by 17.8%.…”

Section: Discussionmentioning

confidence: 99%

“…Cold‐induced thermogenesis tests were performed by exposing the mice to 4 °C with no access to food and water, and rectal temperatures were measured at 1, 2, 3, 4, and 5 h. [ 6 ] Positron emission tomography‐computed tomography (PET‐CT, Siemens Preclinical Solutions, Knoxville, TN, USA) was performed on the mice by injecting 18 F‐FDG as described before. [ 17 ]…”

Section: Methodsmentioning

confidence: 99%

“…Researchers have previously demonstrated that polyphenol monomers, such as rutin, cyanidin‐3‐glucoside (C3G), and vanillic acid (VA), are beneficial in resisting dietary‐induced obesity by stimulating the thermogenesis of BAT in mice. [ 6–8 ] However, the direct utilization of polyphenols by mammals, such as human beings and mice, is quite low as indicated by the small serum concentrations of both polyphenols and their metabolites, which seems to be unable to fulfill their biological functions. [ 9,10 ] Therefore, a more precise relationship between polyphenols and BAT activation needs to be investigated.…”

Section: Introductionmentioning

confidence: 99%

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Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid

Han

Guo

Yin

et al. 2020

Molecular Nutrition Food Res

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Scope: Although the physiological function of grape extract (GE) has long been recognized, the precise mechanism remains obscure. This study is designed to investigate the effects of GE on metabolism and the association between GE activation of brown adipose tissue (BAT) and the restoration of gut microbiota (GM). Methods and results: Diet-induced obese mice are used to investigate the function of GE. GE administration increases energy metabolism and prevents obesity. Also, GE restores the dysbiosis of GM by augmenting the observed species, enhancing the Firmicutes-to-Bacteroidetes ratio and increasing the abundance of the Bifidobacteria, Akkermansia, and Clostridia genera. This restoration of GM alters the bile acid (BA) pool in the serum. The abundance of Akkermansia, Clostridium, and Bifidobacterium is negatively correlated with the concentrations of T MCA, T MCA, and TCA but is positively correlated with DCA. The changes in BA promoted TGR5 in BAT, which contributed to thermogenesis. The metabolites of GE in blood do not stimulate TGR5 in vitro. Conclusion: GE stimulates the thermogenesis of BAT through a pathway involving the regulation of GM and BA in diet-induced obese mice. This study reveals the mechanism by which dietary polyphenols promote thermogenesis by regulating BA, which is altered by GM. ments; X.H. wrote the paper.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid

Han

Guo

Yin

et al. 2020

Molecular Nutrition Food Res

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“…In our previous studies, we found that mulberry extract enhanced the thermogenesis of brown adipocytes in vitro by increasing the number of mitochondria 15 . Cyanidin‐3‐O‐glucoside (C3G) attenuated obesity by promoting the thermogenic capacity of BAT 16,17 . As most dietary polyphenols, such as anthocyanins and flavonoids, are absorbed and fulfill their biological functions through their metabolites, mostly phenolic acids 18,19 .…”

Section: Introductionmentioning

confidence: 99%

p‐Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1‐RPS6

et al. 2020

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Brown adipose tissue (BAT) has long been recognized as an energy‐consuming organ and a possible target for combating metabolism disorder. Although numerous studies have demonstrated the ability of phytochemical phenolic acids to improve obesity by activating BAT, the underlying mechanism or mechanism therein remain obscure. In this study, diet‐induced obese mice, genetically obese mice, and C3H10T1/2 cells were used to examine the effects of p‐Coumaric acid (CA) on metabolism profiles. The results showed that CA prevented metabolic syndromes in the two mice models through the activation of BAT. This phenomenon was closely linked to the upregulation of uncoupling protein 1 (UCP1) and the accelerated burning of fatty acids and glucose, which consequently enhanced the energy expenditure and thermogenesis. Similar results were also obtained in vitro. Importantly, these effects were mediated by the mammalian target of rapamycin complex 1 (mTORC1)‐RPS6 pathway. These findings reveal, to the best of our knowledge for the first time, the close correlation between mTORC1‐RPS6 and BAT‐mediated thermogenesis, and, in addition, the key role played by mTORC1‐RPS6 in mediating phenolic acids‐induced activation of BAT, thus preventing obesity.

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“…Also, C3G supplementation normalized high density lipoprotein (HDL) and serum adiponectin levels in HF‐diet‐induced obese rats . Similarly, in HF and high‐fructose‐diet‐induced obese mice, supplementation with 1 mg per mL C3G anthocyanin in water for 15 weeks increased heat production in inguinal WAT and BAT by increasing mitochondrial function and biogenesis by upregulating uncoupling protein‐1 (UCP‐1) and other thermogenic genes such as peroxisome proliferator‐activated receptor‐gamma coactivator 1 alpha (PGC1α) and transcription factor A, mitochondrial (TFAM) …”

Section: Adipose Tissue Inflammation and Obesitymentioning

confidence: 99%

Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

Jayarathne

Stull

Park

et al. 2019

Molecular Nutrition Food Res

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Obesity is a complex disease and a major public health epidemic. Chronic, low‐grade inflammation is a common underlying feature of obesity and associated metabolic diseases; adipose tissue is a major contributor to this systemic inflammation. Evidence shows that obesity‐associated inflammation may originate from gut dysfunction, including changes in intestinal bacteria or microbiome profiles. Increasingly, food and plant bioactive compounds with antioxidant and anti‐inflammatory properties are proposed to ameliorate obesity‐associated inflammation. Among these, the health‐promoting effects of anthocyanin‐rich foods are of interest here. Specifically, this review summarizes the reported benefits of anthocyanins in obesity‐associated inflammation and underlying molecular mechanisms, including the role of gut microbiome and cell signaling pathways regulated by anthocyanins both in vivo and in vitro.

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Cyanidin-3-glucoside attenuates high-fat and high-fructose diet-induced obesity by promoting the thermogenic capacity of brown adipose tissue

Cited by 51 publications

References 63 publications

Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid

Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid

p‐Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1‐RPS6

Protective Effects of Anthocyanins in Obesity‐Associated Inflammation and Changes in Gut Microbiome

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