Cutaneous metastasectomy: Is there a role in breast cancer? A systematic review and overview of current treatment modalities

Abstract

Cutaneous metastases (CM) are neoplastic lesions involving the dermis or subcutaneous tissues, originating from another primary tumor. Breast cancer is commonest primary solid tumor, representing 24%-50% of CM patients. There is no "standard of care" on management. In particular, the role of surgery in the treatment of cutaneous metastases from breast carcinoma (CMBC) remains controversial. This systematic review evaluates the role of cutaneous metastasectomy in breast cancer and provides an overview of existing treatment types.

Isolated metastasis to the scalp in occult breast cancer: a clinical case

“…Метастатическое поражение кожи является довольно частым симптомом при ряде солидных злокачественных новообразований, в том числе и РМЖ. Среди различных опухолей как причина вторичного внутрикожного поражения РМЖ занимает 1-е место, составляя 25-50% [15,16].…”

“…В настоящее время остается спорной роль оперативного вмешательства при метастазах опухолей в кожу [16,26]. Одни авторы избегают хирургического вмешательства, поскольку свидетельствуют о распространенном опухолевом процессе [27].…”

Cutaneous metastases from breast cancer: Considerations for implementing rigorous evaluation of local therapies

“…To the Editor, We read the article entitled Cutaneous metastasectomy: Is there a role in breast cancer? A systematic review and overview of current treatment modalities by Huang et al 1 aiming to assess the role of local therapy.…”

“…Although Huang et al 1 retrieved 16 papers on ECT in their literature search, only four of these seem to have been listed.…”

“…For example, in patients with chest wall recurrence from breast cancer, the chance of achieving effective tumour control with ECT inversely correlates with the spread of the disease around the mastectomy scar. 9 Huang et al 1 correctly remind us of the necessity of collecting good-quality clinical data on breast cancer patients with skin metastases. We endorse this effort and, in its support, would like to mention the hypothesis-generating study by Cabula et al 10 The authors of this multicentre retrospective analysis evaluated 125 breast cancer patients with skin metastases (median 1/patient, range: 1-3) treated with ECT and reported an overall response rate of 90.2% (complete response rate: 58.4%).…”