Cutaneous melanoma primary site is linked to nevus density

Martín-Gorgojo, Alejandro; Llinares, Marta; Virós, Amaya; Requena, Celia; García-Casado, Zaida; Traves, Víctor; Kumar, Rajiv; Nagore, Eduardo

doi:10.18632/oncotarget.22016

Cited by 8 publications

(4 citation statements)

References 40 publications

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“…Those tumors emerge after a lifetime of cumulative sun exposure in older patients [2,3]. Epidemiological studies have confirmed the divergent pathways hypothesis based on the distribution and number of nevi, UV-related skin damage, patient age at diagnosis, and other clinical aspects [4][5][6][7]. Furthermore, these two populations would correspond to subgroups within the current WHO classification, which differentiates between high-CSD and low-CSD melanomas but considers, for the latter, the proneness to melanocytic proliferation [8].…”

Section: Introductionmentioning

confidence: 84%

Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development

Millán-Esteban

Peña‐Chilet

García-Casado

et al. 2021

Cancers

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According to the divergent pathway model, cutaneous melanoma comprises a nevogenic group with a propensity to melanocyte proliferation and another one associated with cumulative solar damage (CSD). While characterized clinically and epidemiologically, the differences in the molecular profiles between the groups have remained primarily uninvestigated. This study has used a custom gene panel and bioinformatics tools to investigate the potential molecular differences in a thoroughly characterized cohort of 119 melanoma patients belonging to nevogenic and CSD groups. We found that the nevogenic melanomas had a restricted set of mutations, with the prominently mutated gene being BRAF. The CSD melanomas, in contrast, showed mutations in a diverse group of genes that included NF1, ROS1, GNA11, and RAC1. We thus provide evidence that nevogenic and CSD melanomas constitute different biological entities and highlight the need to explore new targeted therapies.

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Section: Introductionmentioning

confidence: 84%

Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development

Millán-Esteban

Peña‐Chilet

García-Casado

et al. 2021

Cancers

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“…A proportion of cutaneous melanomas show remnants of a nevus at the histological level [43]. This suggests that a possible route for the development of melanoma is the route likely to develop a nevus and that a high number of nevi is a risk factor for the development of melanoma [44]. There are reports that differ markedly in the number of melanomas associated with nevi; some figures estimate that this association occurs in up to 58% of cutaneous melanomas [45].…”

Section: Discussionmentioning

confidence: 99%

Mutations in the BRAF, NRAS, and C-KIT Genes of Patients Diagnosed with Melanoma in Colombia Population

Gutiérrez-Castañeda

Gamboa

Nova

et al. 2020

BioMed Research International

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Introduction. Mutations in the BRAF, NRAS, and C-KIT genes have been associated with the histopathological characteristics of melanoma. Likewise, the incidence of each of these subtypes changes according to the geographical origin of the population analyzed. Objective. To determine the mutation frequency in exons 11 and 15 of the BRAF gene, exons 1 and 2 of the NRAS gene, and exons 11, 13, and 17 of the C-KIT gene and to relate it with histological subtypes in patients from a region with high levels of ultraviolet radiation. Methodology. The clinicopathological characteristics of 54 cutaneous melanoma samples were analyzed. Mutation analysis was performed via qPCR on paraffin-embedded tumor tissue samples using probes specific for the V600E mutation. Amplification of exons 11 and 15 of the BRAF gene, exons 1 and 2 of the NRAS gene, and exons 11, 13, and 17 of the C-KIT gene was performed for subsequent sequencing using the Sanger method. Result. The most frequent histological subtype in the analyzed sample was lentigo maligna/lentigo maligna melanoma (52%) followed by acral lentiginous melanoma (20%). The BRAF-V600 variant was the most frequent (63.6%). The most frequent (54%) mutation in NRAS was p.Lys5∗. In the C-KIT gene, only the Val560Ala mutation was found. Conclusion. Differences in histological subtypes and mutations in the BRAF, NRAS, and C-KIT genes were found in the analyzed population. This indicates that environmental and genetic factors significantly influence the introduction of the disease in this geographic region.

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“…For question 5, we specifically leveraged the work done by Richtig et al [ 64 ], Ambros-Rudolph et al [ 65 ], and Mahe et al [ 69 ]. Of note, question 5 was added post hoc given that high densities of nevi have been associated with an increased risk of developing melanoma [ 69 , 74 , 75 ]. No additional records were found utilizing the following search criteria in PubMed: “nevi count AND sports.” The manuscript quality rating used in this review was based on the type of study, study sample size, and the relative strengths of outcomes measured.…”

Section: Methodsmentioning

confidence: 99%

Solar Ultraviolet Exposure in Individuals Who Perform Outdoor Sport Activities

et al. 2020

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Background: Skin cancer is the most common cancer in the USA. Therefore, it is important to review the contribution of ultraviolet radiation (UVR) exposure to skin cancer in individuals with the highest risk. Documenting the relationship between outdoor sports solar ultraviolet exposure and their risk of skin cancer along with appropriate risk mitigation strategies can help inform clinicians of practical information for counseling sun protective behaviors in this population. Methods: We conducted a review of the current evidence using PubMed to answer the following research questions: (1) How is ultraviolet radiation measured? (2) What is the modern utility of the ultraviolet index in modifying recreational sun protection behaviors? (3) What is the risk of developing skin cancer for outdoor sport participants? (4) What is the prevalence of skin cancer in sport participants? and (5) Is the number of nevi and solar lentigines elevated in outdoor sport participants? Results: Based on the literature, individuals who practice outdoor sport-related activities receive high ultraviolet radiation exposure, have a high risk for skin cancer, have a high prevalence for pigmented lesions, and may benefit from electronic sun protection educational interventions. Conclusions: Individuals who practice outdoor sports experience substantially higher ultraviolet radiation exposure, routinely exceed the recommended exposure limits, and are at a higher risk of developing skin cancer. Therefore, those who are frequently engaged in outdoor leisure activities should be coached about efficient sun protective practices and relevant mobile technologies that may facilitate adherence.

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Cutaneous melanoma primary site is linked to nevus density

Cited by 8 publications

References 40 publications

Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development

Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development

Mutations in the BRAF, NRAS, and C-KIT Genes of Patients Diagnosed with Melanoma in Colombia Population

Solar Ultraviolet Exposure in Individuals Who Perform Outdoor Sport Activities

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