Cutaneous leishmaniasis mimicking squamous cell carcinoma

Oetken, Tara; Hiscox, Bryan; Orengo, Ida; Rosen, Theodore

doi:10.5070/d3231033684

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…Some causal relationships between leishmaniasis and malignancy have been evidenced in experimental animals and in humans [ 9 ]. In fact, four different association between these diseases have been described: (a) leishmaniasis mimicking malignancy [ 10 , 11 , 12 , 13 ]; (b) leishmaniasis arising from difficulty diagnosing and treating infection among patients receiving chemotherapy for various malignant disorders [ 14 , 15 ]; (c) simultaneous diagnosis of leishmaniasis and a neoplastic disorder in the same tissue samples of patients [ 16 , 17 , 18 ]; and (d) direct involvement of Leishmania spp. in the pathogenesis of malignant lesions, especially skin and mucous membrane tumors [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

Larrea

Fernández-Rubio

Peña-Guerrero

et al. 2022

IJMS

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Around 15% of cancer cases are attributable to infectious agents. Epidemiological studies suggest that an association between leishmaniasis and cancer does exist. Recently, the homologue of PES1 in Leishmania major (LmjPES) was described to be involved in parasite infectivity. Mammalian PES1 protein has been implicated in cellular processes like cell cycle regulation. Its BRCT domain has been identified as a key factor in DNA damage-responsive checkpoints. This work aimed to elucidate the hypothetical oncogenic implication of BRCT domain from LmjPES in host cells. We generated a lentivirus carrying this BRCT domain sequence (lentiBRCT) and a lentivirus expressing the luciferase protein (lentiLuc), as control. Then, HEK293T and NIH/3T3 mammalian cells were infected with these lentiviruses. We observed that the expression of BRCT domain from LmjPES conferred to mammal cells in vitro a greater replication rate and higher survival. In in vivo experiments, we observed faster tumor growth in mice inoculated with lentiBRCT respect to lentiLuc HEK293T infected cells. Moreover, the lentiBRCT infected cells were less sensitive to the genotoxic drugs. Accordingly, gene expression profiling analysis revealed that BRCT domain from LmjPES protein altered the expression of proliferation- (DTX3L, CPA4, BHLHE41, BMP2, DHRS2, S100A1 and PARP9), survival- (BMP2 and CARD9) and chemoresistance-related genes (DPYD, Dok3, DTX3L, PARP9 and DHRS2). Altogether, our results reinforced the idea that in eukaryotes, horizontal gene transfer might be also achieved by parasitism like Leishmania infection driving therefore to some crucial biological changes such as proliferation and drug resistance.

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Section: Introductionmentioning

confidence: 99%

The BRCT Domain from the Homologue of the Oncogene PES1 in Leishmania major (LmjPES) Promotes Malignancy and Drug Resistance in Mammalian Cells

Larrea

Fernández-Rubio

Peña-Guerrero

et al. 2022

IJMS

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“…Occasional cases involving different parts of the ear have been described where the lesion mimicked neoplastic disease progression [ 127 ]. The lesions of auricular leishmaniasis mimicking squamous cell carcinoma were described [ 128 , 129 , 130 ]. L. tropica is an atypical species causing chiclero’s ulcer ( Figure 3 b) [ 122 , 131 ].…”

Section: Atypical Presentations Of Leishmaniasismentioning

confidence: 99%

Unusual Observations in Leishmaniasis—An Overview

et al. 2023

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Leishmaniasis significantly affects the population of the tropics and subtropics. Clinical features and infective species of Leishmania are the primary factors driving the direction of diagnosis. The rise in incidences of atypical presentations present a challenge in patient treatment. Knowledge of unusual/rare presentations can aid in having a broader perspective for including the different aspects during the examination and thus avoid misdiagnosis. A comprehensive literature survey was performed to present the array of atypical presentations confounding clinicians which have been seen in leishmaniasis. Case reports of unusual findings based on the localizations and morphology of lesions and infective species and the predominant geographical sites over almost five decades highlight such presentations in the population. Information regarding the clinical features recorded in the patient and the chosen treatment was extracted to put forward the preferred drug regimen in such cases. This comprehensive review presents various unusual observations seen in visceral leishmaniasis, post-kala-azar dermal leishmaniasis, cutaneous leishmaniasis, and mucocutaneous leishmaniasis. It highlights the need to consider such features in association with differential diagnosis to facilitate proper treatment of the patient.

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“…For instance, the diagnosis of childhood leukaemia should be carefully differentiated from VL, especially in endemic areas where the concurrent occurrence had been reported (Vasconcelos et al ., 2014 ). Similarly, cutaneous and mucocutaneous leishmaniasis may be clinically misdiagnosed as squamous cell carcinoma (SCC) (Ramos et al ., 2015 ; Oetken et al ., 2017 ). These data point out the possible similar association in clinical manifestations of leishmaniasis and tumoural alterations.…”

Section: The Possible Association Of Leishmaniasis and Malignancies (...mentioning

confidence: 99%