Cutaneous leishmaniasis in a 12-year-old Syrian immigrant

Abstract

A12-year-old girl, who had immigrated from Syria 7 months prior, presented to her general practitioner with a 6-month history of nonpainful papules over her right hand that had increased in size and eventually ulcerated. Over a follow-up period of 2 months, she did not improve despite receiving topical corticosteroids, mupirocin, and oral trimethoprim-sulfamethoxazole for suspected superinfected atopic dermatitis. When we saw her in our tropical diseases clinic, she was afebrile and systemically well, but had erythematous plaques, edema, ulcerations and restricted mobility on her right hand (Figure 1A).Giemsa staining from an ulcer scraping specimen showed numerous amastigotes. The culture was positive for Leishmania species, and polymerase chain reaction (PCR) identified Leishmania tropica. Because we were concerned about the functional mobility of the patient's hand, we prescribed systemic therapy with liposomal amphotericin B, based on local guidelines, which she tolerated well. At followup 4 months later, her lesions had resolved (Figure 1B) and joint mobility was restored.Cutaneous leishmaniasis is a protozoan infection transmitted by the female sandfly. This tropical disease affects 700 000 to 1 million new people annually. 1 Nonhealing ulcers in travellers and migrants from endemic regions, such as Central and South America, the Mediterranean basin, the Middle East and Central Asia, should raise suspicion of cutaneous leishmaniasis. Lack of physician knowledge about the acquisition of cutaneous leishmaniasis, even during short stays abroad, has historically led to delayed diagnosis. 2,3 Differential diagnoses include Nocardia species, mycobacteria, endemic fungi, vasculitis, neoplasia, sarcoidosis and pyoderma gangrenosum. Identification of parasites on smear, histopathology, culture or PCR confirm the diagnosis. 4 The type of Leishmania species, concomitant mucosal involvement, the size, number and location of the lesions, and host immune status are important guides to individualized management. 5 Treatment may be local (e.g., paromomycin preparations, cryotherapy, heat therapy) or systemic (e.g., pentavalent antimonials, miltefosine, azoles and amphotericin B).

Bioinformatics Analysis to Designing a Multi-epitope-based Peptide Vaccine Combat Leishmania major

“…Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis, transmitted to humans by biting a female sandfly. One of the causes of this disease is the intracellular parasite Leishmania major (11,12). Cutaneous leishmaniasis causes ugly ulcers that remain in place for a long time.…”