Cutaneous epitheliotropic lymphosarcoma in a captive white catfish (<i>Ameiurus catus</i> Linnaeus)

Heniff, Ashlyn C.; Chen, Laura R; Christiansen, Emily F.; Harms, Craig A.; Law, J. Mac; Legner, Christian; Linder, Keith E.

doi:10.1111/jfd.13625

Cited by 4 publications

(3 citation statements)

References 29 publications

(31 reference statements)

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“…Retroviruses are well established as a cause of lymphoma in many domesticated mammal species [ 18 ] and are suspected of causing cutaneous lymphomas in pike and muskellunge [ 52 , 53 ]. Although viral etiology is suspected in a number of fish hematopoietic tumours (e.g., lymphoma and lymphosarcoma) [ 30 ], there have been some reports of chemically-induced lymphosarcoma. Chen et al [ 54 ] revealed that a chemical carcinogen such as N-methyl-N’-nitro-N-nitrosoguanidine plays a key role in the progression of lymphosarcoma in channel catfish ( Ictalurus punctatus ).…”

Section: Discussionmentioning

confidence: 99%

“…According to veterinary literature, lymphomas are common in dogs, cats, and pigs, but comparatively rare in horses and other domestic species [ 16 – 19 ]. Lymphoma, defined as a malignant tumour of lymphoid tissue [ 18 ], has been found in a number of fish species including northern pike ( Esox lucius ) [ 20 , 21 ], Japanese medaka ( Oryzias latipes ) [ 22 , 23 ], coho salmon ( Oncorhynchus kisutch ) [ 24 ], black bullhead ( Ameiurus melas ) [ 25 ], rainbow trout ( Oncorhynchus mykiss ) [ 26 ], flower horn (hybrid cichlid) [ 27 ], gold crossback arowana ( Scleropages formosus ) [ 28 ], Atlantic stingray ( Hypanus sabinus ) [ 29 ] and captive white catfish ( Ameiurus catus Linnaeus) [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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A rare case of ocular and testicular T-cell lymphoma in a hermaphrodite koi carp (Cyprinus carpio Linnaeus 1758): clinical, histopathological, and immunohistochemical study

et al. 2023

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Background Lymphatic neoplasia may occur in various types, such as lymphoma, lymphosarcoma, lympholeukemia, and plasmacytoid leukemia. Lymphoma, defined as a malignant tumour of lymphoid tissue, has been found in a number of fish families including Esocidae and Salmonidae. However, the occurrence of lymphoma is rare in those belonging to the Cyprinidae. A final diagnosis of ocular and testicular T-cell lymphoma in the present study was based on the clinical signs, morphology, and texture of the tumour masses in the macroscopic and microscopic examinations. In addition, histopathological and immunohistochemical findings corresponded to T-cell lymphoma characteristics. Case presentation A 2-year-old hermaphrodite koi carp (Cyprinus carpio Linnaeus 1758) with a large ocular mass and severe exophthalmia in the right eye was referred to the Ornamental Fish Clinic in October 2020. Under anesthesia, enucleation was performed. 57 days after enucleation of the right eye, exophthalmia in the left eye was discovered. 221 days after surgery, the fish was discovered to be dead. At necropsy, a large soft tissue mass attached to the left testis was discovered. There were also small whitish nodules on the surface of the liver. Histopathology revealed a hypercellular ocular mass with scant connective tissue. The sections also revealed multifocal hemorrhages, round to ovoid neoplastic cells, mild-to-moderate anisokaryosis and anisocytosis, and mitotic figures. Basophilic neoplastic cells were found in blood vessels within the testicular mass, raising the possibility of systemic spread. The liver showed microscopic metastasis with morphologic similarities to the ocular and testicular tumors. The neoplastic cells infiltrating the left and right eyes as well as the testicular mass were immunohistochemically positive for CD3 but negative for CD20. The masses were diagnosed as T-cell lymphoma based on histopathological and immunohistochemical findings. Conclusions This case report provides the first evidence of clinical, histopathological, morphological, and immunohistochemical findings of an ocular and testicular T-cell lymphoma in a hermaphrodite koi carp (Cyprinus carpio) in Iran.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A rare case of ocular and testicular T-cell lymphoma in a hermaphrodite koi carp (Cyprinus carpio Linnaeus 1758): clinical, histopathological, and immunohistochemical study

et al. 2023

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“…Large-scale pathology reviews monitoring disease occurrence in captivity are sparse; those undertaken indicate that neoplasia is rare when compared to other taxa, with a reported prevalence between 0.4% and 0.5% (Garner, 2013;Stidworthy et al, 2017). Lymphoid neoplasia has to date been reported in a range of teleost fish (Bowser et al, 2002;Harada et al, 1990;Heniff et al, 2022) but only in four elasmobranchs: a sandbar, Carcharhinus plumbeus (Nardo), bonnethead, Sphyrna tiburo (Linnaeus) and white-spotted bamboo shark, Chiloscyllium plagiosum (Anonymous [Bennett]) (Dawe & Berard, 1971;Manire et al, 2013;Rosenberg et al, 2015), and an Atlantic stingray, Hypanus sabinus (Lesueur) (Stilwell et al, 2019). Lymphohaematopoietic neoplasms in fish are primarily derived from lymphoid cells.…”

Section: Introductionmentioning

confidence: 99%

Case series: Lymphoid neoplasia in three elasmobranch species

Archer

Groll

Harvey

et al. 2022

Journal of Fish Diseases

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Elasmobranchs (sharks and rays) are charismatic cartilaginous fish, popular in public aquaria. Almost 200 shark and ray species are listed as threatened by the International Union for Conservation of Nature (IUCN), demonstrating the importance of captive breeding and research programmes. Limited studies investigate diseases of elasmobranchs in captive and free‐living environments, and among available literature neoplasia is rarely reported, with even fewer cases of lymphoid neoplasia documented. This article outlines the first reports of lymphoid neoplasia in three elasmobranch species in which haematopoietic neoplasms have not been reported to date. It summarizes signalment, history and histopathologic findings in an undulate ray, Raja undulata (Lacepede), a common smooth‐hound, Mustelus mustelus (Linnaeus) and a bat ray, Myliobatis californica (Gill). Lesions were confirmed in a wide range of tissues and evidence of lymphoid leukaemia was seen in two cases. This small‐scale review demonstrates that lymphoid neoplasia should be considered as a differential diagnosis in elasmobranchs presenting with lethargy and anorexia and highlights the challenges of immunohistochemical work up.

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Cutaneous epitheliotropic lymphosarcoma in a captive white catfish (Ameiurus catus Linnaeus)

Heniff

Chen

Christiansen

et al. 2022

Journal of Fish Diseases

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A wild caught white catfish (Ameiurus catus Linnaeus) developed multiple cutaneous masses. Cytology revealed neoplastic lymphocytes and microscopy confirmed dermal infiltration with epitheliotropism in the epidermis, oral mucosa, and cornea, without internal organ involvement. Transmission electron microscopy did not identify viral particles. Histopathology supported cutaneous epitheliotropic lymphosarcoma, a condition most commonly reported in mammals. This is the first reported case of cutaneous epitheliotropic lymphosarcoma in an ictalurid and one of the few published cases of this condition in any fish species.

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Cutaneous epitheliotropic lymphosarcoma in a captive white catfish (Ameiurus catus Linnaeus)

Cited by 4 publications

References 29 publications

A rare case of ocular and testicular T-cell lymphoma in a hermaphrodite koi carp (Cyprinus carpio Linnaeus 1758): clinical, histopathological, and immunohistochemical study

A rare case of ocular and testicular T-cell lymphoma in a hermaphrodite koi carp (Cyprinus carpio Linnaeus 1758): clinical, histopathological, and immunohistochemical study

Case series: Lymphoid neoplasia in three elasmobranch species

Cutaneous epitheliotropic lymphosarcoma in a captive white catfish (Ameiurus catus Linnaeus)

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