Cutaneous diphtheria: easy to be overlooked

Cassir, Nadim; Bagnères, D.; Fournier, Pierre‐Edouard; Berbis, P.; Brouqui, Philippe; Rossi, P.

doi:10.1016/j.ijid.2015.01.008

Cited by 4 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Beside respiratory infections, C. diphtheriae may cause skin infections and other invasive diseases such as endocarditis, osteomyelitis, and septic arthritis (53–58). At the moment, non-toxigenic cutaneous diphtheria is the most prevalent clinical presentation (24, 39, 57, 59, 60). Wound infections often occur with other skin pathogens, such as Streptococcus pyogenes or S. aureus (28, 31).…”

Section: Microbiology and Pathogenicity Of C Diphtheriaementioning

confidence: 99%

See 1 more Smart Citation

Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings

Seth-Smith

Egli

2019

Front. Public Health

View full text Add to dashboard Cite

Corynebacterium diphtheriae ( C. diphtheriae ) is a relatively rare pathogen in most Western countries. While toxin producing strains can cause pharyngeal diphtheria with potentially fatal outcomes, the more common presentation is wound infections. The diphtheria toxin is encoded on a prophage and can also be carried by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis . Currently, across Europe, infections are mainly diagnosed in travelers and refugees from regions where diphtheria is more endemic, patients from urban areas with poor hygiene, and intravenous drug users. About half of the cases are non-toxin producing isolates. Rapid identification of the bacterial pathogen and toxin production is a critical element of patient and outbreak management. Beside the immediate clinical management of the patient, public health agencies should be informed of toxigenic C. diphtheriae diagnoses as soon as possible. The collection of case-related epidemiological data from the patient is often challenging due to language barriers and social circumstances. However, information on patient contacts, vaccine status and travel/refugee route, where appropriate, is critical, and should be documented. In addition, isolates should be characterized using high resolution typing, in order to identify transmissions and outbreaks. In recent years, whole genome sequencing (WGS) has become the gold standard of high-resolution typing methods, allowing detailed investigations of pathogen transmissions. De-centralized sequencing strategies with redundancy in sequencing capacities, followed by data exchange may be a valuable future option, especially since WGS becomes more available and portable. In this context, the sharing of sequence data, using public available platforms, is essential. A close interaction between microbiology laboratories, treating physicians, refugee centers, social workers, and public health officials is a key element in successful management of suspected outbreaks. Analyzing bacterial isolates at reference centers may further help to provide more specialized microbiological techniques and to standardize information, but this is also more time consuming during an outbreak. Centralized communication strategies between public health agencies and laboratories helps considerably in establishing and coordinating effective surveillance and infection control. We review the current literature on high-resolution typing of C. diphtheriae and share our own experience with the coordination of a Swiss-German outbreak.

show abstract

Section: Microbiology and Pathogenicity Of C Diphtheriaementioning

confidence: 99%

“…Providing state-of-the-art diagnostics for rare and unexpected pathogens can be a challenge for the clinician (39) and the routine microbiology laboratory (40–42). Often specific diagnostic tests are only available in reference laboratories, thus further delaying efficient therapy, surveillance reporting, and outbreak management.…”

Section: Introductionmentioning

confidence: 99%

Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings

Seth-Smith

Egli

2019

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…There is also the potential for C. diphtheriae to cause skin infections which result in cutaneous diphtheria across the globe in patients with varying vaccination status and travel histories (Gordon et al, 2011;Romney et al, 2006;Huhulescu et al, 2014;Cassir et al, 2015;Nelson et al, 2016). These infections are often associated with travel to C. diphtheriae prevalent endemic areas (FitzGerald et al, 2015;Lindhusen-Lindhe et al, 2012;May et al, 2014).…”

mentioning

confidence: 99%

Evolution, epidemiology and diversity of Corynebacterium diphtheriae : New perspectives on an old foe

Sangal

Hoskisson

2016

Infection, Genetics and Evolution

View full text Add to dashboard Cite

Insights into old and new foes: Pan-genomics of Corynebacterium diphtheriae and Corynebacterium ulcerans

Sangal

Burkovski

2020

Pan-Genomics: Applications, Challenges, and Future Prospects

View full text Add to dashboard Cite

Cutaneous diphtheria: easy to be overlooked

Cited by 4 publications

References 5 publications

Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings

Whole Genome Sequencing for Surveillance of Diphtheria in Low Incidence Settings

Evolution, epidemiology and diversity of Corynebacterium diphtheriae : New perspectives on an old foe

Insights into old and new foes: Pan-genomics of Corynebacterium diphtheriae and Corynebacterium ulcerans

Contact Info

Product

Resources

About