Cutaneous Bipolaris spicifera infection

Feohifomicosis nasal por Curvularia spicifera en un paciente pediátrico con neutropenia y leucemia mieloide aguda

“…Las infecciones cutáneas asociadas con C. spicifera han sido reportadas en forma de abscesos, nódulos subcutáneos, úlceras persistentes y lesiones induradas que evolucionan a úlceras necróticas 1,15,[25][26][27] . También, se ha descrito la progresión de una lesión cutánea a una infección diseminada en tratamientos tardíos 14 . En este caso, se describe una feohifomicosis nasal, donde a pesar de haber hallazgos de inflamación pansinusal no hubo evidencia de infección fúngica sinusal.…”

Pyoderma Gangrenosum with a Contiguous Erosion of the Distal Ulna

“…5 Infections caused by Bipolaris spicifera have been reported in both immunocompromised and immunocompetent hosts, although more commonly in the former. 1 Reported cases include meningitis, 3 allergic fungal sinusitis, 6 necrotizing pneumonia, 4 mediastinitis, 4 fungemia, 4 fungal endarteritis, 4 osteoarthritis, 7 and keratitis. 1 Cutaneous lesions associated with B. spicifera usually present as abscesses in immunocompetent patients and as erythematous indurated lesions in immunocompromised individuals.…”

“…1 Reported cases include meningitis, 3 allergic fungal sinusitis, 6 necrotizing pneumonia, 4 mediastinitis, 4 fungemia, 4 fungal endarteritis, 4 osteoarthritis, 7 and keratitis. 1 Cutaneous lesions associated with B. spicifera usually present as abscesses in immunocompetent patients and as erythematous indurated lesions in immunocompromised individuals. 8 One case, reported in 1977, was similar to this case, in which a neutropenic 5-year-old boy with ALL developed an erythematous macule which evolved into a necrotizing ulcer.…”

“…8 One case, reported in 1977, was similar to this case, in which a neutropenic 5-year-old boy with ALL developed an erythematous macule which evolved into a necrotizing ulcer. 9 Straka et al 1 reported a 35-year-old female with acute leukemia who developed a FIGURE 2 Histologic section of resected specimen from patient. (A) A clear area of ulceration and granulation tissue is noted, containing multiple hyphal forms.…”

“…5 For the immunocompromised patient in which such an infection is unlikely to resolve without treatment, therapy for localized cutaneous lesions requires surgical debridement with infection-free margins 8 or surgical excision with or without adjunctive systemic antifungal chemotherapy. 1 Early skin biopsy and surgical treatment can prevent local expansion 1 as well as disseminated disease. 8 Once the fungus has spread, antifungal treatment with amphotericin B, ketoconazole, 5-flurocytosine, miconazole, or itraconazole may be of benefit.…”