Pyoderma Gangrenosum with a Contiguous Erosion of the Distal Ulna

Bilu, Donna; Movahedi–Lankarani, Saeid; Kazin, Rebecca A.; Shields, Christine; Moresi, Margaret

doi:10.1007/s10227-004-0108-6

Cited by 19 publications

(12 citation statements)

References 33 publications

(26 reference statements)

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“…and Phialophora spp. are the next most common fungi, followed by Cladosporium spp., Exserohilum spp., Veronaea botryosa, and many others with scattered case reports (7,12,19,23,32,36,56,61,65,81,140,143,194,209,230,241,251,258,306,313,342,362,365,369,387,413,418,421,457,469,482,486,487,495,539,559,556,568,571,576,590,609,613,614,646,659,694,699,720,728,…”

Section: Phaeohyphomycosismentioning

confidence: 99%

Melanized Fungi in Human Disease

2010

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SUMMARY Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. Many are soil organisms and are generally distributed worldwide, though certain species appear to have restricted geographic ranges. Though they are uncommon causes of disease, melanized fungi have been increasingly recognized as important pathogens, with most reports occurring in the past 20 years. The spectrum of diseases with which they are associated has also broadened and includes allergic disease, superficial and deep local infections, pneumonia, brain abscess, and disseminated infection. For some infections in immunocompetent individuals, such as allergic fungal sinusitis and brain abscess, they are among the most common etiologic fungi. Melanin is a likely virulence factor for these fungi. Diagnosis relies on careful microscopic and pathological examination, as well as clinical assessment of the patient, as these fungi are often considered contaminants. Therapy varies depending upon the clinical syndrome. Local infection may be cured with excision alone, while systemic disease is often refractory to therapy. Triazoles such as voriconazole, posaconazole, and itraconazole have the most consistent in vitro activity. Further studies are needed to better understand the pathogenesis and optimal treatment of these uncommon infections.

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Section: Phaeohyphomycosismentioning

confidence: 99%

Melanized Fungi in Human Disease

2010

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“…La búsqueda en la literatura especializada mostró 11 casos pediátricos (menores de 18 años) de infección por B. spicifera (Tabla 1), involucrando distintos sitios y sistemas. Cuatro casos ocurrieron en pacientes inmunocomprometidos, de los cuales dos tuvieron infección fúngica diseminada 25,26 y los otros dos, infecciones cutáneas localizadas 15,16 . En todos los casos el diagnóstico se confirmó por histopatología, microscopia y/o cultivos de muestras de fluidos corporales, secreciones o tejidos obtenidos por biopsia.…”

Section: Discussionunclassified

“…El género Curvularia incluye más de 80 especies, de las cuales la mayoría se encuentran en la tierra, plantas y materia inorgánica [4][5][6] . Su distribución es mundial, pero se ha reportado principalmente en regiones tropicales y subtropicales 7 , asociado a diferentes tipos de infecciones, tales como queratitis y úlceras corneales 8 , sinusitis 9-12 , micetoma 13 , infecciones cutáneas y subcutáneas [14][15][16] , peritonitis asociada a diálisis 17,18 , endarteritis 19 , absceso cerebral 19,20 , meningitis y encefalitis 21,22 , alergia broncopulmonar 18,23,24 e infecciones diseminadas [24][25][26] . Curvularia spp.…”

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Feohifomicosis nasal por Curvularia spicifera en un paciente pediátrico con neutropenia y leucemia mieloide aguda

Bay

González²,

Muñoz

et al. 2017

Rev. chil. infectol.

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“…Furthermore, it may lead to infection of the peritoneum, bronchus and other debilitating conditions, including meningitis and disseminated infections (10)(11)(12)(13)(14)(15)(16)(17)(18). da Cunha et al (8) identified that Bipolaris spicifera was one of the major pathogenic species, accounting for 67.3% in all 104 clinical samples morphologically compatible with Bipolaris.…”

Section: Discussionmentioning

confidence: 99%

The first case of cutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China: A case report

Pan

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Phaeohyphomycosis (PHM) is a term used to describe any fungus presenting in tissues with pseudohyphae, hyphae, brown yeast-like cells or a combination of these forms. Sinusitis and skin infections are the most common presentation of subcutaneous PHM caused by the fungus Bipolaris spicifera. However, the majority of cases have so far been encountered in tropical climatic zones. The present study documents a case of subcutaneous PHM caused by infection with Bipolaris spicifera in a 56-year-old Chinese man, who presented with plaque papillomatosis on the left foot. The organism isolated from the lesion scar and tissue was identified as Bipolaris spicifera by its morphology, histopathology and DNA sequencing. The patient was successfully treated with itraconazole and terbinafine. IntroductionPhaeohyphomycosis (PHM) refers to phaeoid fungal infections with specific structures including pseudohyphae, hyphae and brown yeast-like cells seen in tissue samples (1,2). Currently, there are at least 60 genera and 109 species that can cause PHM. The most frequent etiologic agents are Exophiala spinifera, Wa ngiella spinifera, Phialophora spinifera a nd Bipolaris spinifera (3).PHM-inducing agents are widely distributed around the world; however, they are more frequently observed in tropical and subtropical climates (4). PHM occurs in immunocompromised and immunocompetent individuals, although organ transplantation, cancer, leukemia, prolonged hospitalization and corticosteroid therapy are predisposing factors (5,6). Cases of PHM have been reported in different regions such as the Caribbean islands, parts of South America, Africa, the Indian subcontinent, Southeast Asia, and the West Pacific Islands (3). The incidence in patients with solid organ transplantation is ~9% (5).PHM may be categorized as either superficial, cutaneous and corneal, subcutaneous, and systemic PHM (5). Bipolaris spicifera is typically associated with subcutaneous PHM and symptoms such as sinusitis and skin infections (7,8). The majority of cases so far have been encountered in tropical climatic zones (5). The present case, however, exhibits the first case of subcutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China, in an area with a subtropical climate. Case reportA 56-year-old Chinese male presenting with papular nodules and plaque papillomatosis on the left foot was admitted into the Department of Dermatology, Qingdao University Affiliated Hospital (Qingdao, China) in June 2014. Initial onset was characterized by the appearance of scattered papules and nodules on the dorsum of the left foot 10 years previously, without clinical symptoms. The lesion converged gradually, formed a granuloma-like lesion and spread from the hallux to the dorsum of the foot and the second, third and fourth toes, with occasional co-presentation of bloody pus. The patient also had a prior medical history of rheumatoid arthritis for one year prior to this onset. The patient was a farmer living in Shandong Province, had never traveled outside the ...

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Pyoderma Gangrenosum with a Contiguous Erosion of the Distal Ulna

Abstract: This case demonstrates another example of cortical osteolysis directly adjacent to a PG ulcer in which the bony changes may be neutrophil-induced.

Cited by 19 publications

References 33 publications

Melanized Fungi in Human Disease

Melanized Fungi in Human Disease

Feohifomicosis nasal por Curvularia spicifera en un paciente pediátrico con neutropenia y leucemia mieloide aguda

The first case of cutaneous phaeohyphomycosis caused by Bipolaris spicifera in Northern China: A case report

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