Feohifomicosis nasal por Curvularia spicifera en un paciente pediátrico con neutropenia y leucemia mieloide aguda

Bay, Constanza; González, Tamara; Muñoz, Gonzalo; Legarraga, Paulette; Vizcaya, Cecilia; Abarca, Katia

doi:10.4067/s0716-10182017000300014

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…1 These organisms are morphologically characterized by the formation of dark colonies, septate hyphae or black-yeasts elements. 2 The pigmentation of dematiaceous fungi is associated with the presence of melanin in its cell wall, which acts as an important virulence factor in the development of fungal infections in humans, such as phaeohyphomycosis. 3 Ungual phaeohyphomycosis are examples of non-dermatophytic onychomycosis, responsible for 1.5% to 18% of the cases of these infections.…”

Section: Introductionmentioning

confidence: 99%

“…7 The genus Curvularia has a worldwide coverage that is mostly found in soil and in plants. 2 Due to this, most cases of phaeohyphomycosis induced by these fungi occur in men aged 30-50 years, working in rural areas or other occupations that expose them to plant materials. 8,9 H. werneckii, although with worldwide distribution, is mainly found in regions of tropical and subtropical climates of Central and South America, Africa and Asia and in places with high salt concentration.…”

Section: Introductionmentioning

confidence: 99%

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In vitro Antifungal Susceptibility of Agents for Superficial Phaeohyphomycosis

Pagnussat

Machado

Scarton

2020

SPDV

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The selection of fungal isolates resistant to available therapy associated with an increase in the number of immunosuppressed patients has contributed to the incidence of infections caused by dematiaceous fungi. Thus, this study evaluated the therapeutic efficacy of the main antifungal agents currently used in clinical practice in relation to Curvularia spp. and Hortaea werneckii from cases of superficial phaeohyphomycosis from southern Brazil. The susceptibility profile of amphotericin B, fluconazole, itraconazole, terbinafine and voriconazole against dematiaceous fungi (Curvularia lunata, C. pallescens and H. werneckii) was evaluated by microdilution in broth. Terbinafine showed greater efficacy against C. lunata - gemometric mean (GM = 0.38 μg/mL), C. pallescens (MIC = 0.125 μg/mL) and H. werneckii (GM = 0.031 μg/mL) when compared to the other antifungals tested. Most of species showed sensitivity to itraconazole and voriconazole, with a minimum inhibitory concentration (MIC) range from 1 - 8.0 μg/mL and 0.5 - 2.0 μg/mL, respectively. All isolates tested show low sensitivity to fluconazole (MIC range 4 - 16 μg/mL). Although itraconazole is considered gold standard, terbinafine has been showed to be a good alternative for the treatment of superficial phaeohyphomycosis. Lastly, antifungal susceptibility testing is essential to indicate the ideal therapy against these infections.

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Section: Introductionmentioning

confidence: 99%