Cutaneous adverse events related to COVID ‐19 vaccines: A cross‐sectional questionnaire‐based study of 867 patients

Abstract

Considering the emergency approval of the Food and Drug Administration for widespread use of coronavirus disease 2019 (COVID-19) vaccines, evaluating potential vaccine-related adverse effects is critical as it will allow physicians to diagnose and manage these complications properly. In this descriptive cross-sectional questionnaire-based study, we evaluated the possible side effects of the COVID-19 vaccine from June 1, 2021 to June 21, 2021. The Iranian population is generally vaccinated with AstraZeneca, Sputnik V, Sinopharm, and Bharat vaccines. The continuous and categorical variables were described and data analyzed by the SPSS software version 25. Cutaneous reactions occurred in 30% of individuals vaccinated against COVID-19. The most common cutaneous complications were focal injection site reaction, exanthematous rash, and urticaria. There were infrequent cutaneous adverse events that included vesicular eruption, pernio-like lesions, angioedema, erythema multiforme-like eruption, and zoster. Acquainting physicians with COVID-19 vaccine-related cutaneous complications will assist them in detection and management. In addition, introducing these complications to individuals might improve acceptance of vaccine-related adverse effects in the general population.

Cutaneous adverse reactions to coronavirus vaccines: A Saudi nationwide study

“…Several cutaneous reactions have been reported after COVID‐19 vaccination such as injection site reaction, exanthematous rash, urticaria, vesicular eruption, chilblain‐like lesions, erythromelalgia, angioedema, erythema multiforme‐like lesion, and zoster. 9 , 11 , 12 , 13 Similar results were found in our local registry. However, our study found a lower incidence of cutaneous adverse reactions affecting only 5% of the population that could either be explained by the separate calculation of injection site reactions including pain, swelling, and redness from other cutaneous reactions or by the fact that there was an actual lower incidence in the Saudi population.…”

“…Several cutaneous reactions have been reported after COVID‐19 vaccination such as injection site reaction, exanthematous rash, urticaria, vesicular eruption, chilblain‐like lesions, erythromelalgia, angioedema, erythema multiforme‐like lesion, and zoster 9,11–13 . Similar results were found in our local registry.…”

Comparative study of immunogenicity and safety of Gam-COVID-Vac and Sinopharm BBIBP-CorV vaccines in Belarus

“…Skin manifestations in the vaccinated subjects were transient. The most common reactions were pain at the injection site (79.9% of Sputnik V (Gam-COVID-Vac) vaccine users, 60.6% of Sinopharm vaccine users), tightening of the injection site (13.4% of Sputnik V (Gam-COVID-Vac) vaccine users, 10.3% of Sinopharm (BBIBP-CorV) vaccine users), reddening of the skin at the injection site (12.8% of Sputnik V (Gam-COVID-Vac) vaccine users, 6.9% of Sinopharm (BBIBP-CorV) vaccine users) [20].…”

Facial Angioedema after the first dose of Covishield (adenovirus-vectored severe acute respiratory syndrome coronavirus 2 vaccine): follow-up after the second and third booster doses

“…Although angioedema is considered a typical manifestation of immediate-type reactions, it can also occur with delayed reactions 6 . Angioedema has been reported after SARS-Cov-2 vaccines 7 )-( 8 , including Covishield, but the underlying pathophysiological mechanism remains unknown. It is important to note that angioedema has also been described as a manifestation of SARS-Cov-2 infection itself 9 )-( 10 .…”