Cushing's syndrome induced by misuse of topical corticosteroids in a child with psoriasis vulgaris

Rahmayunita, Githa; Pulungan, Aman B; Wiryadi, Benny Effendi; Wisesa, Tina W.; Sugito, Titi Lestari; Boediardja, Siti Aisah

doi:10.13181/mji.v17i4.323

Cited by 3 publications

(3 citation statements)

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“…2,14 Systemic side effects of TS are more easily manifested in children because of higher body surface area as compared to body weight. 16 Owing to slower drug metabolism in children, if the frequency and the duration of topical corticosteroid ointment application is increased, there is more propensity to develop side effects. 17 Allenby et al, in a study on 39 patients, found that application of more than 50 g per week of clobetasol propionate ointment on the skin leads to HPA axis suppression.…”

Section: Discussionmentioning

confidence: 99%

“…Multiple factors that are implicated in development of ICS are the age of the patient, size of lesions, the integrity of epithelium, localization of lesions, duration of therapy with TS or oral steroids, and the potency of drug 2,14 . Systemic side effects of TS are more easily manifested in children because of higher body surface area as compared to body weight 16 . Owing to slower drug metabolism in children, if the frequency and the duration of topical corticosteroid ointment application is increased, there is more propensity to develop side effects 17 .…”

Section: Discussionmentioning

confidence: 99%

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Iatrogenic Cushing's syndrome due to topical steroid abuse in a child with Psoriasis presenting as septicaemia

Sachdeva

Arora

Kulhari

et al. 2020

Dermatologic Therapy

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Psoriasis vulgaris is a chronic inflammatory disorder that affects the skin and joints. Mild disease is treated with topical corticosteroids (CS) which forms the first line of treatment for localized disease. While it is well established that prolonged use of oral or parenteral corticosteroids can lead to iatrogenic Cushing's syndrome and suppression of hypothalamic pituitary axis; development of these complications secondary to use of topical CS is rarely described. Since steroids have anti‐inflammatory properties, their prolonged use can lead to increased susceptibility to develop bacterial and fungal infections. We hereby report a 11‐year‐old female with psoriasis who presented with septicaemia and features of iatrogenic Cushing's syndrome due to treatment with topical corticosteroids for 2 years. Presentation of ICS as septicemia due to topical steroid use in this age group or in a psoriatic patient has not been described in the literature so far. Patient also developed hypertension and osteopenia, which are known adverse effects of corticosteroids; but occur rarely due to topical corticosteroids.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Iatrogenic Cushing's syndrome due to topical steroid abuse in a child with Psoriasis presenting as septicaemia

Sachdeva

Arora

Kulhari

et al. 2020

Dermatologic Therapy

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“…However, over 75% of patients belong to a clear sub group that develops the disease before the age of 40 with reported prevalence ranging from 2% to 4.7%. [1][2][3] Psoriasisis characterized by round, erythematous, well-marginated plaques covered by characteristic grayish or silvery white scales with predilection on the scalp, elbows, knees and lumbosacral and anogenital regions. Many factors should be considered in choosing treatment for psoriasis.…”

Section: Introductionmentioning

confidence: 99%

Topical Steroid Induced Iatrogenic Cushing Syndrome in Young Adult Age Group: A Case Report

George¹,

ApolloJames²,

Reddy³

et al. 2015

IJOPP

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Background: Cushing syndrome is a systemic disorder, occurs as a result of abnormal blood level of cortisol. Prolonged use of topical corticosteroid may cause Cushing syndrome which is very rare and only a few patients have been reported to date in the literatures. Objectives: To evaluate the prompt medical care given for topical corticosteroids induced Iatrogenic caushing syndrome. Results: Clinical symptoms are reduced within one week of treatment with Methotrexate, Prednisone and emollients. Conclusion: Results of the study indicates that the health awareness should be created among general public to avoid the unnecessary drug induced complications.

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Infantile Exogenous Cushing Syndrome due to Misuse of Topical Corticosteroid

Seyedzadeh¹

2012

J Clin Case Rep

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Cushing's syndrome induced by misuse of topical corticosteroids in a child with psoriasis vulgaris

Cited by 3 publications

References 0 publications

Iatrogenic Cushing's syndrome due to topical steroid abuse in a child with Psoriasis presenting as septicaemia

Iatrogenic Cushing's syndrome due to topical steroid abuse in a child with Psoriasis presenting as septicaemia

Topical Steroid Induced Iatrogenic Cushing Syndrome in Young Adult Age Group: A Case Report

Infantile Exogenous Cushing Syndrome due to Misuse of Topical Corticosteroid

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