Cushing’s syndrome in childhood

Desai, Meena; Colaco, Prisca; Merchant, S. M.

doi:10.1007/bf02834442

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Other treatment modalities such as anterior lobe hypophysectomy, bilateral adrenalectomy and X-ray irradiation therapy are unacceptable for children because of their maiming character, making further somatic development and sexual maturation impossible for children [3, 10, 12, 13, 14, 15]. Transsphenoidal surgery, especially the sublabial route, is well tolerated in children and has fewer side effects than other modalities [6, 8, 9, 11, 16]. The transnasal transsphenoidal approach carries some cosmetic postoperative problems because of the narrow nasal orifices in children.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Therapeutic Properties of Cushing’s Disease in Childhood

Çırak

Palaoğlu²,

Akalan³

1999

Pediatr Neurosurg

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Cushing's disease (CD) in adolescence and childhood is a rare pathology and has some different clinical and therapeutic characteristics than in adults. We report 3 cases treated surgically, with the diagnosis of CD. Their common complaints were short stature and obesity. Endocrinological investigations and radiological evaluation pointed out the diagnosis of CD for all children. They were operated on by the transsphenoidal route, and adenoma resection was performed. Histopathologic and immunohistochemical examination of the tissue specimens confirmed the diagnosis of CD. Long-term follow-up demonstrated weight loss and increase in height.

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Section: Discussionmentioning

confidence: 99%

Clinical and Therapeutic Properties of Cushing’s Disease in Childhood

Çırak

Palaoğlu²,

Akalan³

1999

Pediatr Neurosurg

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“…Leukemia was the leading type of cancer and malignant tumors were the second most common cancer in several countries. [20][21][22] Majority of our cases are in 10-15 years. This is similar to observation by SEER, Mankodi et al, and Baneerjee and Walia.…”

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confidence: 99%

Solid malignant pediatric tumors: a histopathological study

Gupta

Choudhary

Pachar

et al. 2017

Int J Contemp Pediatr

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Background: In general, the features of malignancies in children differ biologically and histologically from those of adults with respect to incidence, type of tumor, underlying familial or genetic aberration and tendency to regress spontaneously or cytodifferentiation. In recent years, identification of specific genes, oncogenes, tumor markers and other biological and pathological factors have played an important role in staging and classifying risk categorization of specific tumors as low, intermediate and high-risk lesions.Methods: This study is under taken to evaluate the incidence and morphological features of solid malignant tumors in children of fifteen years and below. The material for present study is obtained from S. P. Medical College, Bikaner and referred cases. The histopathology slides and paraffin blocks are reviewed.Results: The sections 3-5 μ thick, are cut and stained by haematoxylin and eosin in all cases and special stains like PAS, MTS, RS done where ever feasible. An analysis of 60 cases of solid malignant tumors of childhood over a period of 5years are made. The early onset and the embryonal nature of the major pediatric tumors, suggest a prenatal origin and role of genetic factors. Infections, exposure to drugs and chemicals during pregnancy are other contributory factors.Conclusions: Accurate incidence of data is important in the planning and evaluation of clinical trials. Documentation of cases, advanced diagnostic methods like IHC, cytogenetic studies and treatment modalities with close follow up is needed to achieve better statistical evaluation of the problem.

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