“…The majority of individuals with CD remain undiagnosed. This fact has been illustrated by the concept of a "celiac iceberg" in which the overall prevalence of CD equates to the total size of the iceberg, diagnosed cases represent the tip of the iceberg visible above the water line, and the submerged portion of the iceberg represents individuals with undiagnosed CD [21]. There are an estimated 5-10 undiagnosed cases for every diagnosed case of CD [13].…”
Celiac Disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Although classic symptoms of CD primarily involve the gastrointestinal tract, extra-intestinal symptoms are common as well. In this review, we examine psychiatric disorders that occur in association with CD, examine pathophysiological mechanisms that may be responsible for these comorbid conditions, and suggest areas of research that could both improve our understanding and reveal potential new treatments for these psychiatric disorders.
“…The majority of individuals with CD remain undiagnosed. This fact has been illustrated by the concept of a "celiac iceberg" in which the overall prevalence of CD equates to the total size of the iceberg, diagnosed cases represent the tip of the iceberg visible above the water line, and the submerged portion of the iceberg represents individuals with undiagnosed CD [21]. There are an estimated 5-10 undiagnosed cases for every diagnosed case of CD [13].…”
Celiac Disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten in genetically susceptible individuals. Although classic symptoms of CD primarily involve the gastrointestinal tract, extra-intestinal symptoms are common as well. In this review, we examine psychiatric disorders that occur in association with CD, examine pathophysiological mechanisms that may be responsible for these comorbid conditions, and suggest areas of research that could both improve our understanding and reveal potential new treatments for these psychiatric disorders.
“…Karl Mårild et al reviewed the literature on this topic and concluded that there was still only circumstantial evidence that the perinatal environment influences coeliac disease development. Annelie Carlsson discusses the paper in her editorial and asks whether currently diagnosed cases of coeliac disease are just the tip of the iceberg ? …”
Section: Is Coeliac Disease Nature or Nurture And Is This Just The Timentioning
Sequential testing for anti-tTG using first a highly sensitive assay followed by a very specific assay is a new strategy for screening for CeD in clinical practice.
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