A Review of Psychiatric Disorders Associated with Celiac Disease

Liester, Mitchell B.; Liester, Maya G.

doi:10.21767/2472-5048.100035

Cited by 6 publications

(8 citation statements)

References 180 publications

(187 reference statements)

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“…Noncompliance to this diet is associated with different gastrointestinal and nongastrointestinal manifestations (Nikniaz, Farhangi, Hosseinifard, & Nikniaz, 2019; Nikniaz, Farhangi, & Nikniaz, 2020; Rivera, Assiri, & Guandalini, 2013). One of the important nongastrointestinal disorders with high prevalence in patients with CD was psychiatric disorders (Liester & Liester, 2017). Numerous psychiatric disorders are associated with CD such as depression, bipolar disorder, anxiety disorders, and eating disorders (EDs; Liester & Liester, 2017).…”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of the prevalence and odds of eating disorders in patients with celiac disease and vice‐versa

Nikniaz

Beheshti

Farhangi

et al. 2021

Intl J Eating Disorders

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Objectives In the present systematic review and meta‐analysis study, we aimed to review studies that assessed the prevalence and risk of eating disorders (EDs) in patients with celiac disease (CD) and vice‐versa. Method We conducted a systematic search in PubMed, Embase, Scopus, and Web of Science for studies that assessed the prevalence and risk of AN in patients with CD and vice‐versa. Joanna Briggs Institute tools were used for critical appraisal. The STATA software was used for the meta‐analysis of the random‐effect model. Results In this study, 23 observational studies were included. The results of the meta‐analysis indicated that the pooled prevalence of EDs and bulimia nervosa in patients with CD was 8.88% [95% CI: 6.4, 11.7] and 7.26% [95% CI: 0.23, 21.57], respectively. Moreover, the risk of anorexia nervosa in patients with CD was significantly higher than in the healthy population (relative risk [RR]: 1.48 [95% CI: 1.32, 1.64]). The rates of CD in patients with AN and EDs were 0.96% [95% CI: 0.15, 2.31] and 0.90% [95% CI: 0.56, 1.31], respectively. Moreover, the overall risk of CD in patients with AN was significantly higher compared with healthy adults (RR: 2.35 [95% CI: 1.27–3.44]). Discussion The result of the present meta‐analysis showed the high prevalence of EDs in patients with CD. Moreover, there was a significant bidirectional association between CD and EDs.

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Section: Introductionmentioning

confidence: 99%

A systematic review and meta‐analysis of the prevalence and odds of eating disorders in patients with celiac disease and vice‐versa

Nikniaz

Beheshti

Farhangi

et al. 2021

Intl J Eating Disorders

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“…A growing body of evidence suggests that mood symptoms are associated with a spectrum of gluten-related disorders [ 9 , 11 , 12 ]. Reports of health improvements after following a GFD in the absence of CD has led to non-coeliac gluten sensitivity (NCGS) becoming increasingly recognised as its own clinical entity [ 13 ], with evidence indicating a higher prevalence than CD [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Whilst the GFD for autism spectrum disorders has been well reviewed [ 38 , 39 ], other reviews of psychiatric and mood disorders in relation to gluten have focussed on CD and epidemiological, rather than interventional, evidence [ 12 , 40 ]. Meanwhile, a review on extra-intestinal symptoms in NCGS [ 41 ] included only one study considering psychiatric outcomes [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

Mood Disorders and Gluten: It’s Not All in Your Mind! A Systematic Review with Meta-Analysis

et al. 2018

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Gluten elimination may represent an effective treatment strategy for mood disorders in individuals with gluten-related disorders. However, the directionality of the relationship remains unclear. We performed a systematic review of prospective studies for effects of gluten on mood symptoms in patients with or without gluten-related disorders. Six electronic databases (CINAHL, PsycINFO, Medline, Web of Science, Scopus and Cochrane Library) were searched, from inception to 8 August 2018, for prospective studies published in English. Meta-analyses with random-effects were performed. Three randomised-controlled trials and 10 longitudinal studies comprising 1139 participants fit the inclusion criteria. A gluten-free diet (GFD) significantly improved pooled depressive symptom scores in GFD-treated patients (Standardised Mean Difference (SMD) −0.37, 95% confidence interval (CI) −0.55 to −0.20; p < 0.0001), with no difference in mean scores between patients and healthy controls after one year (SMD 0.01, 95% CI −0.18 to 0.20, p = 0.94). There was a tendency towards worsening symptoms for non-coeliac gluten sensitive patients during a blinded gluten challenge vs. placebo (SMD 0.21, 95% CI −0.58 to 0.15; p = 0.25). Our review supports the association between mood disorders and gluten intake in susceptible individuals. The effects of a GFD on mood in subjects without gluten-related disorders should be considered in future research.

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“…With renewed research interest in the brain-gut axis in psychiatry, clinicians and researchers have increasingly focused on neuroinflammation and immune system activation in psychiatric disorders (1). Within this domain, research on gluten protein ingestion and the potential development of symptoms of schizophrenia is an area of resurgent and exciting research.…”

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confidence: 99%

“…Researchers first linked gluten to schizophrenia after World War II. As Nordic populations ended rationing of wheat products, researchers noted a significant correlation between abrupt increases in wheat consumption and first-episode psychosis (1). By 1948, case reports emerged describing comorbidity between childhood celiac disease and schizophrenia (2).…”

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confidence: 99%