Current Insight on Trends, Causes, and Mechanisms of Hodgkin’s Lymphoma

Caporaso, Neil E.; Goldin, Lynn R.; Anderson, William F.; Landgren, Ola

doi:10.1097/ppo.0b013e3181a39585

Cited by 43 publications

(25 citation statements)

References 88 publications

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“…21). Both genetic and environmental factors may predispose an individual to develop an HL; the relative risk of HL being highest (approximately 100-fold) in monozygous twins (22)(23)(24)(25). Such predisposing factors might also increase the risk for a second clonally unrelated HL in patients with "recurrent" disease, as observed also in our cohort, especially with second and third recurrences after a relapse.…”

Section: Discussionsupporting

confidence: 54%

Clonal Relationship of Classical Hodgkin Lymphoma and Its Recurrences

Obermann

Mueller

Rufle

et al. 2011

Clinical Cancer Research

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Purpose: We investigated whether the first and all subsequent manifestations of Hodgkin lymphoma (HL) in a patient are clonally related.Experimental Design: We identified a collective of 20 patients with sometimes multiple HL recurrences. Relapses were classified as early, that is, within twelve months (eight events in seven patients) or as late, that is, later than one year after the previous neoplasm (24 events in 17 patients). Hodgkin and Reed-Sternberg cells were microdissected after CD30 staining using laser capture technique. Immunoglobulin heavy chain (IgH) gene fragment lengths were analyzed after DNA preamplification, applying consensus FR3 and J primers by ABI 310 Genetic Analyzer. Sequencing of the amplified IgH products was carried out by ABI 3130 and 3730XL Genetic Analyzer. Epstein-Barr virus (EBV) association was assessed by EBV early RNA and LMP1.Results: Three cases with early relapses after a first HL diagnosis were clonally related to the initial tumor, whereas three of four patients with early relapses after a first or second relapse were not, which was accompanied by change of EBV association in one case. Six patients presenting with late relapses were clonally unrelated, which was accompanied by change of phenotype in two cases and change of EBV association in one case. Two samples from recurrent tumors of the same patient could be successfully sequenced. These two late relapses were clonally unrelated by IgH fragment length and sequencing analysis.Conclusions: Recurrent HL, especially those accompanied by an EBV-association switch or after a relapse, can represent an unrelated novel neoplasm. Our finding might play a role in clinical decision making. Clin Cancer Res; 17(16); 5268-74. Ó2011 AACR.

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Section: Discussionsupporting

confidence: 54%

Clonal Relationship of Classical Hodgkin Lymphoma and Its Recurrences

Obermann

Mueller

Rufle

et al. 2011

Clinical Cancer Research

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“…In addition environmental and lifestyle differences between the USA and Asia are important. In some study from Eastern Asia and among Chinese immigrants in North America indicate increasing incidence trends for HL being associated with westernization (Caporaso, Goldin, Anderson, & Landgren, 2009). International and interethnic differences and risk factor patterns in case-control data, implicate environmental influences in the etiology of HL (Glaser & Hsu, 2002).…”

Section: Descriptive Epidemiologymentioning

confidence: 99%

Epidemiology of Lymphoid Malignancy in Asia

Mozaheb¹

2012

Epidemiology Insights

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“…However, this process is responsible for several adverse effects on different tissues. When combined with chemotherapy it makes normal tissues more sensible to radiations, and this may increase the risk of complications in relation to radiotherapy [1,2].…”

Section: Introductionmentioning

confidence: 99%

Platelet-Rich Plasma (PRP) in a Post Radiotherapy Sternal Ulcer in a Patient with Hodgkin's Lymphoma

P¹

2015

J Blood Disord Transfus

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Radiotherapy is an essential part of the multidlevel treatment for Hodgkin's Lymphoma. However but it is responsible for several adverse effects on different tissues. The tissue damage may occur immediately or over a prolonged period of time. A 33 years old woman, with a diagnosis of Hodgkin lymphoma, nodular sclerosis histotype, II grade according to WHO classification, stage 2A has been examined for this study. At the physical examination, the ulcer was of 6 x 5 cm, 2 cm deep, of circular shape, with uneven margins. There was rash around the lesion too. The wound was infected with abundant serous and fibrinous exudate in the center and squamous-crostous formations around the center itself. The lesion was bleeding and smelled bad. Platelet gel has been applied once a week with a control after 3 days to check and evaluate the conditions of the medication.The situation improved after the first two applications with a noticeable reduction of the rash and inflammation. During the fourth level of application the first areas of granulation tissue appeared and by the end of the eighth cycle, the therapy concluded with the lesion completely re-epitelized. Platelet gel showed to be effective and accomplished a complete re-epitelization of the lesion after eight cycles. At the same time, it allowed us to proceed with the myeloablative chemotherapy, which was the most appropriate therapeutic choice for the Hodgkin's disease but was supposed to enhance the risk of infective complications of the ulcer.

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Current Insight on Trends, Causes, and Mechanisms of Hodgkin’s Lymphoma

Cited by 43 publications

References 88 publications

Clonal Relationship of Classical Hodgkin Lymphoma and Its Recurrences

Clonal Relationship of Classical Hodgkin Lymphoma and Its Recurrences

Epidemiology of Lymphoid Malignancy in Asia

Platelet-Rich Plasma (PRP) in a Post Radiotherapy Sternal Ulcer in a Patient with Hodgkin's Lymphoma

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