Platelet-Rich Plasma (PRP) in a Post Radiotherapy Sternal Ulcer in a Patient with Hodgkin's Lymphoma

Abstract

Radiotherapy is an essential part of the multidlevel treatment for Hodgkin's Lymphoma. However but it is responsible for several adverse effects on different tissues. The tissue damage may occur immediately or over a prolonged period of time. A 33 years old woman, with a diagnosis of Hodgkin lymphoma, nodular sclerosis histotype, II grade according to WHO classification, stage 2A has been examined for this study. At the physical examination, the ulcer was of 6 x 5 cm, 2 cm deep, of circular shape, with uneven margins. There was rash around the lesion too. The wound was infected with abundant serous and fibrinous exudate in the center and squamous-crostous formations around the center itself. The lesion was bleeding and smelled bad. Platelet gel has been applied once a week with a control after 3 days to check and evaluate the conditions of the medication.The situation improved after the first two applications with a noticeable reduction of the rash and inflammation. During the fourth level of application the first areas of granulation tissue appeared and by the end of the eighth cycle, the therapy concluded with the lesion completely re-epitelized. Platelet gel showed to be effective and accomplished a complete re-epitelization of the lesion after eight cycles. At the same time, it allowed us to proceed with the myeloablative chemotherapy, which was the most appropriate therapeutic choice for the Hodgkin's disease but was supposed to enhance the risk of infective complications of the ulcer.

Homologous platelet gel on radiation-induced dermatitis in a patient receiving head and neck radiotherapy plus cetuximab: A case report

“…[7][8][9][10][11] In line with the biostimulatory role of platelets, several studies have documented the healing properties of platelet concentrates in the treatment of radiodermatitis lesions. [12][13][14][15][16][17] In particular, the use of platelet gel has emerged as a promising new treatment modality for radiodermatitis. This approach involves the utilization of platelet-rich plasma (PRP), a concentrated source of platelets that can be activated by exposure to calcium ions and the addition of thrombin.…”

“…[7–11] In line with the biostimulatory role of platelets, several studies have documented the healing properties of platelet concentrates in the treatment of radiodermatitis lesions. [12–17]…”