Current Developments on Anti-Inflammatory Natural Medicines

Das, Sayanna; Mandal, Sudip Kumar

doi:10.22159/ajpcr.2018.v11i8.26523

Cited by 17 publications

(11 citation statements)

References 65 publications

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“…The extract of rosemary contains phenols which have the ability of inhibition on the cell walls and cell membranes synthesis, nucleic acid metabolism and on the Gram-positive and Gram-negative bacteria and wide range on bacteria and fungi inhibition. Accordingly, using alcoholic or oil extract of rosemary can give stronger antibacterial activity than the aqueous extract of rosemary [38,39]. In addition, other factors such as pH and temperature of the extract solution should be considered in determining its antibacterial activity according to Ali et al [40].…”

Section: Discussionmentioning

confidence: 99%

Estimation the Antibacterial Effect of Curcumin and Rosemary Among Patients With Dental Caries in Vitro

Al-Sharifi¹,

Al-Mahmood²,

Al-Mahmood³

2019

Asian J Pharm Clin Res

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Objective: The aim is to estimate the effect of curcumin and rosemary as antibacterial agents among dental caries cases. Methods: Samples of saliva were randomly collected from 40 patients in Al-Furat General Hospital who attended the hospital from July to September 2018. Swabs were cultured on blood agar at 37°C for 24 h and then subcultured in mannitol salt agar and trypticase soy broth at 37°C for 24 h. Different concentrations of aqueous extract curcumin solution (0.1, 0.3, 0.5, and 1 mg/ml) and rosemary solution (1 g/ml) were prepared and added to the bacterial culture. Later, minimum inhibition zones of the bacterial cultures were determined. Results: The results showed that there were 25 cases of Streptococcus mutans, 10 cases of Staphylococcus aureus, 3 cases of anaerobic bacteria, and 2 cases of normal flora among 40 culturing swabs of bacteria. Aqueous extract of curcumin showed antibacterial effect with concentrations (0.1, 0.3, 0.5, and 1 mg/ml) against oral bacteria; nevertheless, these bacteria were resistant to the aqueous extract of rosemary with concentration 1 g/ml. Conclusion: It can be concluded that curcumin can be an effective antibacterial agent against dental caries disease and its effect increases positively in relation to its concentration. On the other hand, rosemary with 1 g/ml concentration did not show any effect on oral bacteria.

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Section: Discussionmentioning

confidence: 99%

Estimation the Antibacterial Effect of Curcumin and Rosemary Among Patients With Dental Caries in Vitro

Al-Sharifi¹,

Al-Mahmood²,

Al-Mahmood³

2019

Asian J Pharm Clin Res

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“…Chemical enhancer like pyolidones, azones, oxizolidinones, cyclodextrines are used to disturbing the ordered structure of stratum corneum interacting with the proteins to improve the drug partition [10,11]. Terpenes (1,8-cineole, menthol, limonene, thymol) [12][13][14] and essentials oils (neem oil, chenopodium, basil oil) are used as skin penetration enhancers and act as promising non-toxic, non-irritating agents to improve the bioavailability of both lipophilic and hydrophilic drugs [8,12,15]. The effects of natural penetration enhancer could be increased with increase in diffusion coefficient, partition coefficient, solubility of drug extraction of lipids, terpenes molecular orientation with lipid bilayer [12,14,16].…”

Section: Fig 1 Types Of Permeation Enhancersmentioning

confidence: 99%

Formulation, Development and Physicochemical Characterization of Diclofenac Topical Emulgel

Nayak¹,

Mandal²,

Ramadan³

et al. 2021

Egypt. J. Chem.

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Emulgel is one of the convenient and promising topical drug delivery approaches especially for the hydrophobic drugs. The purpose of the study was to prepare emulgel of diclofenac sodium using polymers namely Carbopol-934, hydroxypropyl methyl cellulose and sodium carboxy methyl cellulose and studied for their drug release from the gel formulations. The 1% Carbopol-934 formulated gel was found highest drug content (101.72%) than the other formulations. The pH of the formulations ranged from 6.8 to 7.2 and viscosity is from 36,000 to 51,000 cps. Extrudability of carbopol and HPMC gels were excellent than the SodiumCMC gel. In vitro drug release was observed highest (64.91%) for the formulation A2 (1% Carbopol-934) and was improved further on the addition of DMSO as a permeation enhancer. In the same time, 1.0% carbopol-940 also showed a similar release pattern, but the release was lesser (51.47%) and the release of HPMC and sodium CMC gels was much lesser. The study revealed that formulation A2 with 1% Carbopol-934 was observed to be the best formulation having good in vitro release profile, stability and bioavailability among all prepared formulations. Hence, the study brought to a close idea that the emulgel A2 was a successful outcome as a topical anti-inflammatory and analgesic formulation among all.

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“…Oral administration of allicin showed comparable activity with the standard drug diclofenac sodium [21]. Allicin and few other organosulpher compounds also suppressed LPSinduced inflammation [22].…”

Section: Anti-inflammatory and Anti-arthritic Activitymentioning

confidence: 99%

Bioactivities of Allicin and Related Organosulfur Compounds from Garlic: Overview of the Literature Since 2010

Mandal¹,

Das²,

Dey³

et al. 2019

Egypt. J. Chem.

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T HE medical values of garlic, a traditionally used allium vegetable, were recognized as early as 3000 BC. Allicin, one of the major organosulfur compounds present in garlic, is associated with a wide variety of benificial activities like anticancer, anti-inflammatory, antiarthritic, antimicrobial, anti-diabetic, cholesterol-lowering, the potential to lower cardiovascular disorders, ameliorating neuron functions, etc. In this article, we have reviewed biological activities of allicin and related organosulfur compounds since the year 2010, using various scientific websites like Pub med, Google Scholar, Science Direct etc. Our literature review has highlighted many organo sulphur components of garlic and their possible mechanisms in curing different diseases. The information provided in this review will provide strategies for efficient organosulfur-based treatments of several diseases in future. Further research efforts are needed for a clear understanding of the interconnection between these functional components and various chronic diseases.

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Current Developments on Anti-Inflammatory Natural Medicines

Cited by 17 publications

References 65 publications

Estimation the Antibacterial Effect of Curcumin and Rosemary Among Patients With Dental Caries in Vitro

Estimation the Antibacterial Effect of Curcumin and Rosemary Among Patients With Dental Caries in Vitro

Formulation, Development and Physicochemical Characterization of Diclofenac Topical Emulgel

Bioactivities of Allicin and Related Organosulfur Compounds from Garlic: Overview of the Literature Since 2010

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