Formulation, Development and Physicochemical Characterization of Diclofenac Topical Emulgel

Nayak, Amrita; Mandal, Sudip Kumar; Ramadan, Mohmmed A; Rath, Santosh Kumar

doi:10.21608/ejchem.2021.58467.3259

Cited by 2 publications

(2 citation statements)

References 40 publications

(54 reference statements)

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“…Based on the dynamics of the release of active substances, have been studied concerning gelforming substances, it is established that different types of gelling agents affect the release of active substances from emulgels differently. [15][16][17][18][19][20][21] Flavonoids are maximally released from the emulgel, prepared based on 1.5% carbopol. During the study of the rheological characteristics of the experimental emulgel, it was discovered that there was an inversely proportional relationship between the viscosity efficiency and the shear speed values at different stages in all the analysis intervals.…”

Section: Discussionmentioning

confidence: 99%

Technology and Composition of Saperavi-Based Cosmetic Emulgel

Kirvalidze,

Bakuridze,

Berashvili

et al. 2023

Georgian Biomedical News

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Background: In recent years, wine has gained increasing recognition as a functional food product that is essential for the treatment and prevention of various kinds of diseases. Saperavi grape variety, which has a high concentration of phenolic compounds, is particularly noteworthy from the perspective of its application in cosmetology practices. Objectives: In this research, we have determined the recipe and developed the technology of the cosmetic emulgel that contains wine and oil of the Georgian grape variety "Saperavi." Methods: Modern pharmaco-technological, biopharmaceutical, physicochemical, and structural and mechanical methods were used in the research. The pH of the aqueous fluid extraction of the researched emulgels was determined by the potentiometric titration method. The osmotic activity of emulgels was determined by the gravimetric method. The colloidal stability of emulgels was determined on a laboratory centrifuge. The rheological characteristics of the composition were studied on a Viscometer RVDV-1 T. Results: Based on biopharmaceutical studies, the recipe of Saperavi emulgel was developed with the following composition: saperavi wine 20.0 g, carbopol 940 -1.5 g, propylene glycol -5.0 g, glycerin -5.0 g, Saperavi grapeseed oil -5.0 g, Tween 80 -1.0 g, sodium hydroxide -0.8 g, sorbic acid -0.45 g, potassium sorbate -0.15 g, purified water up to 100.0 g. Using Saperavi emulgel on the clean facial skin of volunteers for 21 days led to a sharp reduction in oiliness, cleansing of pores, reduction in the number of keratinocytes, and noticeable whitening of pigment spots. Conclusions: Overall, the Saperavi wine cosmetic emulgel formula and technology have been developed through this study. Additionally, the developed emulgel demonstrated some therapeutic benefits on volunteers' skin.

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Section: Discussionmentioning

confidence: 99%

Technology and Composition of Saperavi-Based Cosmetic Emulgel

Kirvalidze,

Bakuridze,

Berashvili

et al. 2023

Georgian Biomedical News

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“…The appearance, pH, skin irritation, viscosity, spreadability, extrudability, drug content, homogeneity, diffusion and stability of the prepared emulgel were all tested (Table 3). [19][20][21]…”

Section: Qualitative Physicochemical Evaluation Of Emulgelmentioning

confidence: 99%

Preclinical evaluation of topical emulgel containing fixed dose allo-herbal combination in imiquimod induced psoriasis

Deshpande,

Amale,

Lingait

et al. 2024

IJCED

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Psoriasis is a well-known autoimmune, progressive inflammatory condition having long-term impact on the patient's physical and psychological well-being with worldwide prevalence. The available allopathic and herbal medicines have their own merits and demerits. Allopathic drugs may produce potent beneficial as well as adverse effects while alone herbal drugs may exert slow and less potent effects. Hence the current study attempted to prepare and evaluate fixed dose combination of allo-herbal emulgel in order to minimize adverse effects and improve beneficial effects during the treatment of psoriasis. This study used a well-established, robust, and validated model (Imiquimod (IMQ)) for psoriasis induction. Emulgel was formulated and tested using phytochemical and physicochemical methods. The anti-psoriatic and anti-inflammatory activities of the prepared emulgel were investigated. In addition, percent release and in vivo absorption were done to ensure adequate release and absorption of emulgel content. Progress of psoriasis induction and treatment was analyzed by morphological and histopathological studies.The formulated emulgel was found to comply with the standard physicochemical test with the desired release pattern. Morphological and histological data showed induction of psoriasis using the IMQ model, and significant improvement was observed after emulgel treatment. All formulations were discovered to significantly reduce formalin-induced inflammation.The present study provided the rationale for the combination of C. amada and P. pinnata with salicylic acid. The selected allo-herbal combination and optimized dosage form are stable, biocompatible, and effective anti-inflammatory and anti-psoriatic with potentially fewer side effects.

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Formulation, Development and Physicochemical Characterization of Diclofenac Topical Emulgel

Cited by 2 publications

References 40 publications

Technology and Composition of Saperavi-Based Cosmetic Emulgel

Technology and Composition of Saperavi-Based Cosmetic Emulgel

Preclinical evaluation of topical emulgel containing fixed dose allo-herbal combination in imiquimod induced psoriasis

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