Current developments in drug delivery with thermosensitive liposomes

Bi, Hongshu; Xue, Jianxiu; Jiang, Hong; Gao, Shan; Yang, Dongjuan; Fang, Yan; Shi, Kai

doi:10.1016/j.ajps.2018.07.006

Cited by 60 publications

(41 citation statements)

References 112 publications

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“…TSL is composed of a thermo‐sensitive phosphocholine lipid (DPCC 85% molar ratio), and the melting of DPCC increases the permeability of TSL. [ 47 ] The drug, BDQ, release profile upon laser irradiation, suggest that the melting of the TSL resulted in the release of the drug from final nano‐assemblies (Figure 4D). The melting of TSL (48 ± 3 °C) was further evaluated by calcein dye release assay.…”

Section: Resultsmentioning

confidence: 99%

Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

et al. 2021

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To combat the rise of antibiotic resistant bacteria, it is essential to look upon other therapeutic solutions that do not solely depend upon conventional antibiotics. Here, we have designed a combinational therapeutic approach that kills bacteria with the conjunction of photothermal (PT) and antibiotic therapy. A near‐infrared (NIR) laser activated targeted drug delivery nano‐assembly delivers antibiotic as well as offer PT therapy (PTT). The synergistic application of both therapies increases the efficacy of treatment. The protected delivery of antibiotic and its release in the proximity of the bacteria surface reduces off‐target toxicity and reduce the efficacious dosage. Core of the nano‐assembly is composed of NIR active gold nanorods (GNRs) coated with a mesoporous silica nanoparticle (MSNP), which serves as a carrier for an anti‐tuberculosis drug bedaquiline (BDQ). The assembly was wrapped within a thermo‐sensitive liposome (TSL) conjugated to mycobacteria‐targeting peptide: NZX, GNR@MSNP@BDQ@TSL@NZX. NZX mediates adhesion of final nano‐assembly on mycobacteria surface. Upon NIR laser irradiation GNRs convert photo energy of the laser to localized heat, which melts TSL triggering release of BDQ. Antibacterial activity of final nano‐assembly against Mycobacterium smegmatis (Msmeg) was 20 folds more efficacious than the free drug equivalent. The final nano‐assembly could also successfully inhibit the growth of intracellular mycobacteria residing in lung cells.

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Section: Resultsmentioning

confidence: 99%

Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

et al. 2021

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“…Multiple approaches have been employed to utilize highfrequency magnetic fields in drug delivery and hyperthermia for tumour ablation 7,8,61,62 . One of the most promising designs uses MNPs to release therapeutic cargos from micro/nano hollow capsules (for example, liposomes) [63][64][65] or solid particles (for example, polymer based) [66][67][68] . For example, MNPs (such as Fe 3 O 4 , γ-Fe 2 O 3 ) embedded in drug-loaded biodegradable polymers, such as poly(lactic-co-glycolic acid) (PLGA), have been shown to trigger and release the cargo when excited with alternating magnetic fields (100 kHz to 200 kHz) 66 .…”

Section: Static and Low-frequency Magnetic Fields Static And Low-frequency Magnetic Fields Can Be Generated By Magnets Or Electromagnetsmentioning

confidence: 99%

Wireless on-demand drug delivery

2021

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“…The release of the drug can be deliberately triggered by different techniques, such as ultrasound, light, magnetism, or hyperthermia. Several experts in the field attempted to modify the surface of the liposomes to improve their capability to target different types of cancer and accumulate at the site of the tumors, delivering a higher concentration of the drug [ 32 , 88 , 89 , 90 ]. Liposomes can also be employed to alter DNA, anticancer agents, and antibiotics to improve chemotherapy by adding specific molecules to their surface, according to the tumor type or gene delivery, these being the most encouraging tools for cancer gene therapy [ 91 , 92 , 93 ].…”

Section: Nanosystems Involved In Treating Lung Cancermentioning

confidence: 99%

The Nanosystems Involved in Treating Lung Cancer

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et al. 2021

Life

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Even though there are various types of cancer, this pathology as a whole is considered the principal cause of death worldwide. Lung cancer is known as a heterogeneous condition, and it is apparent that genome modification presents a significant role in the occurrence of this disorder. There are conventional procedures that can be utilized against diverse cancer types, such as chemotherapy or radiotherapy, but they are hampered by the numerous side effects. Owing to the many adverse events observed in these therapies, it is imperative to continuously develop new and improved strategies for managing individuals with cancer. Nanomedicine plays an important role in establishing new methods for detecting chromosomal rearrangements and mutations for targeted chemotherapeutics or the local delivery of drugs via different types of nano-particle carriers to the lungs or other organs or areas of interest. Because of the complex signaling pathways involved in developing different types of cancer, the need to discover new methods for prevention and detection is crucial in producing gene delivery materials that exhibit the desired roles. Scientists have confirmed that nanotechnology-based procedures are more effective than conventional chemotherapy or radiotherapy, with minor side effects. Several nanoparticles, nanomaterials, and nanosystems have been studied, including liposomes, dendrimers, polymers, micelles, inorganic nanoparticles, such as gold nanoparticles or carbon nanotubes, and even siRNA delivery systems. The cytotoxicity of such nanosystems is a debatable concern, and nanotechnology-based delivery systems must be improved to increase the bioavailability, biocompatibility, and safety profiles, since these nanosystems boast a remarkable potential in many biomedical applications, including anti-tumor activity or gene therapy. In this review, the nanosystems involved in treating lung cancer and its associated challenges are discussed.

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Current developments in drug delivery with thermosensitive liposomes

Cited by 60 publications

References 112 publications

Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

Near‐infrared responsive targeted drug delivery system that offer chemo‐photothermal therapy against bacterial infection

Wireless on-demand drug delivery

The Nanosystems Involved in Treating Lung Cancer

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