Current concepts of regenerative biomaterials in implant dentistry

Ahuja, Annapurna; Ahuja, Vipin; Singh, Kumar Saurav

doi:10.4103/2231-0754.172943

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…Membranes should present suitable degradation rates matching the tissue formation to achieve the desired restoration. Currently, GTR membranes based on biodegradable polymers (mainly xenogenic collagen) are commercially available, nevertheless, those membranes present poor mechanical properties and high solubility in physiological conditions resulting in difficult clinical manipulation and early rupture at the tissue defect site during GTR treatment [3]. Another important challenge in GTR procedures are the infections generated by bacterial colonization at the membrane [4].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

et al. 2020

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Section: Introductionmentioning

confidence: 99%

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

et al. 2020

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“…One disadvantage of the non-resorbable membranes is that they must be removed in a second-stage surgical procedure about six months after placement [9]. Resorbable membranes (mainly composed of xenogenic collagen) must not be removed but frequently exhibit poor mechanical properties and fast biodegradation, which can cause a lack of stability, complicating surgical handling and premature rupture during the treatment, negatively affecting the periodontal regeneration process [10]. Another critical challenge is the control of local infections caused by bacterial colonization on the membrane, which is favored by the physiological fluids in the oral cavity, such as blood and saliva [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

ZnO nanoparticles-modified polycaprolactone-gelatin membranes for guided/bone tissue regeneration, antibacterial and osteogenic differentiation properties

Prado-Prone

Silva-Bermúdez

Rodil

et al. 2023

Biomed. Phys. Eng. Express

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Periodontitis is a highly prevalent infectious disease that causes the progressive destruction of the periodontal supporting tissues. If left untreated, it can lead to tooth loss impairing oral function, aesthetics, and the patient’s overall quality of life. Guided and Bone Tissue Regeneration (GTR/BTR) are surgical therapies based on the placement of a membrane that prevents epithelial growth into the defect, allowing the periodontal/bone cells (including stem cells) to regenerate or restore the affected tissues. The success of these therapies is commonly affected by the local bacterial colonization of the membrane area and its fast biodegradation, causing postoperative infections and a premature rupture of the membrane limiting the regeneration process. This study presents the antibacterial and osteogenic differentiation properties of polycaprolactone-gelatin (PCL-G) electrospun membranes modified with ZnO nanoparticles (ZnO-NPs). The membranes´ chemical composition, surface roughness, biodegradation, water wettability, and mechanical properties under simulated physiological conditions, were analyzed by the close relationship with their biological properties. The PCL-G membranes modified with 1, 3, and 6 wt.% of ZnO-NPs showed a significant reduction in the planktonic and biofilm formation of four clinically relevant bacteria; A. actinomycetemcomitans serotype b, P. gingivalis, E. coli, and S. epidermidis. Additionally, the membranes presented appropriate mechanical properties and biodegradation rates to be potentially used in clinical treatments. Notably, the membranes modified with the lowest concentration of ZnO-NPs (1 wt.%) stimulated the production of osteoblast markers and calcium deposits in human bone marrow-derived mesenchymal stem cells (BM-MSC) and were biocompatible to human osteoblasts cells (hFOB). These results suggest that the PCL-G membranes with 1 wt.% of ZnO-NPs are high-potential candidates for GTR/BTR treatments, as they were the most effective in terms of better antibacterial effectiveness at a lower NPs-concentration while creating a favorable cellular microenvironment for bone growth.

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Synthesis and characterization of 3D-printed functionally graded porous titanium alloy

et al. 2020

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Current concepts of regenerative biomaterials in implant dentistry

Cited by 5 publications

References 2 publications

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

Antibacterial composite membranes of polycaprolactone/gelatin loaded with zinc oxide nanoparticles for guided tissue regeneration

ZnO nanoparticles-modified polycaprolactone-gelatin membranes for guided/bone tissue regeneration, antibacterial and osteogenic differentiation properties

Synthesis and characterization of 3D-printed functionally graded porous titanium alloy

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