Current Concepts and Occurrence of Epithelial Odontogenic Tumors: I. Ameloblastoma and Adenomatoid Odontogenic Tumor

Lee, Suk Keun; Kim, So Hyun

doi:10.4132/koreanjpathol.2013.47.3.191

Cited by 52 publications

(40 citation statements)

References 84 publications

(46 reference statements)

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“…In any event, these structures are not true ducts, and no glandular elements are present in the tumour. Small foci of calcification may also be scattered throughout the tumor [32] . These have been interpreted as abortive enamel formation (Figure 4).…”

Section: Ameloblastic Fibro-odontomamentioning

confidence: 99%

“…In addition, two-thirds of cases show scattered dot-like (snowflake) opacities within the unilocular radiolucency [31] . There have been reported cases of root resorption associated with AOT [32] . Microscopically, the histopathologic features of this lesion are very distinctive to be separated from any other odontogenic tumor.…”

Section: Ameloblastic Fibro-odontomamentioning

confidence: 99%

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Controversial Odontogenic Hamartomas- Review on Their Pathogenesis and Histopathology

Banerjee¹,

Tanu²,

Singroha³

et al. 2017

Journal of Tumor

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metimes understated. There always lays a big controversy depicting an entity as hamartoma. Hamartomas are frequently encountered in major organs like liver, lung, pancreas etc. but the occurrence in oral cavity is rare. The lesions enlisted in this review may not be true hamartomas but depicts strong correlation to neoplasms. Understanding the hamartomatous nature of an odontogenic entity will help us understanding the outcome of the treatment and chances of fatality HAMARTOMASHamartomas, which are dysmorphic or morphologically altered proliferation of cells native to the organ in which they arise, gain a certain size before ceasing their proliferation. This type of biologic behavior may be expansile and is locally resorptive of bone but does not invade adjacent tissue. ODONTOGENIC GINGIVAL EPITHELIAL HAMARTOMA (OGEH)There are two important sources that are responsible for the development of the odontogenic group of lesions; cell rests of Serres (remnants of dental lamina) and cell rests of Malassez (remnants of Hertwig epithelial root sheath). These cell rests are found as clusters which upon getting stimulus give rise to pathological entities. The terminology OGEH was initially suggested by Baden et al [1,2] . This lesion has a rare occurrence, prevalent mostly in the middle age group (3 rd to 5 th decade) and most commonly seen in females (M: F-1: 7) [1,2,3] . The lesion present as a slowly growing, recurrent in occurrence in the soft tissues like gingiva and vestibule. ABSTRACTOdontogenic tumour represents as growth and swellings of variedorigin. The histopathological features of hamartomatous odontogenic entities are not very distinct from neoplasms, but they exhibit different biological behavior. The pathobiology of these lesions is so-

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Section: Ameloblastic Fibro-odontomamentioning

confidence: 99%

Section: Ameloblastic Fibro-odontomamentioning

confidence: 99%

Controversial Odontogenic Hamartomas- Review on Their Pathogenesis and Histopathology

Banerjee¹,

Tanu²,

Singroha³

et al. 2017

Journal of Tumor

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“…Desmoplastic ameloblastoma and clear cell ameloblastoma are considered to be more aggressive [1]. In recent years, many researchers published and reviewed the immune profile and genotyping of different variants of AB [20][21][22][23]. Additional work will be necessary to identify that one specific for the mucous ameloblastoma in order to determine its biological behavior and predicate outcome.…”

Section: A) C) B)mentioning

confidence: 99%

New Features in Mucous-Ameloblastoma. A Case Report of rare Entity

Gataa¹,

Garib²,

Rashid³

2015

Int J Oral Craniofac Sci

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Histologically ameloblastoma showed various forms of metaplastic changes. Evidence of mucous cells is a rare finding and only 9 cases were reported. We present a case of 80 year old male suffered from mandibular swelling for five years duration diagnosed as mucous ameloblastoma. Histopathological examination revealed a lot of mucous pools within the growth, a thin fibrous capsule surrounding the mass and a direct connection between growth islands and oral mucosa. This case highlights the features of rare type of ameloblastoma.2014) seeking help and treatment because the mass became larger and start to interfere with eating and speaking. On the presentation, the patient had extensive right side mandibular expansion; measuring 7X5 cm ( Figure 1A). There was no paresthesia of the mandibular nerve and no trismus. The swelling exhibited diffuse margins and was painless and do not adhere to the overlying skin.Intra orally, there was diffused swelling extending in an edentulous area from the distal surface of the mandibular right canine to the ramus anterio-posteriorly obliterating the right buccal vestibule. The central area of the overlying mucosa showed large deep necrosis, the remaining mucosa stretched and erythematous ( Figure 1E). There was no lymph node palpable in the neck.Orthopantomography and CT examination revealed a large, welldefined unilocular radiolucency with a scalloped border and central septa. It extends from mandibular right edentulous premolar area to the ramus ( Figure 1B and 1C).A diagnosis of ameloblastoma was considered depending on the clinical, radiographic, and previous histopathological report of the lesion. Subsequently, it was removed by surgical excision as an en bloc resection (hemi mandibulectomy, Figure 1D), and the surgical specimen submitted for histologic examination.Macroscopically, the surgical specimen is the right half of the mandible (from midline to the condyle). Only anterior teeth were present. The specimen measured 12X9 cm, (including the condyle head). The mass was grayish-white in color, rubbery with a smooth surface and was well separated from the bone at posterior border, fixed in formalin. The specimen sliced, and several samples were taken for histologic examination (one from the anterior bony margins). The cut surface showed nodular white-yellowish areas and numerous focal cystic spaces of variable sizes oozing thick mucinous material. The mass was well capsulated by thin smooth continues wall ( Figure 1F). Microscopic examination revealed numerous odontogenic

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“…Treatment of the primary ameloblastoma usually consists of radical excision of the tumor and adjuvant radiotherapy, with the aim of minimizing the chances of recurrence and metastasis or its high-grade counterpart, i.e. ameloblastic carcinoma (2,3). However, there is considerable debate in the literature as to whether chemotherapy should be used to treat metastases due to its indolent clinical course.…”

Section: Introductionmentioning

confidence: 99%