Current and Future Trends in Microfluidics within Biotechnology Research

Tian, Wei-Chang; Finehout, Erin

doi:10.1007/978-0-387-09480-9_11

Cited by 3 publications

(3 citation statements)

References 77 publications

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“…Other examples of such advances include artificial cells, synthetic “hybrid” biomolecules, and synthetic biomaterials. Future products that embody “inner space” will include artificial organs and nanoparticles that can detect and target disease [ 211 ]. Potential applications could include on-chip cell and tissue monitoring, drug discovery, and rapid clinical diagnostics.…”

Section: The Future Of Microfluidicsmentioning

confidence: 99%

Microfluidics for Peptidomics, Proteomics, and Cell Analysis

et al. 2021

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Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control chemical, biological, and physical processes relevant to separation, analysis, and detection. Currently, microfluidic devices play an important role in many biological, chemical, physical, biotechnological and engineering applications. There are numerous ways to fabricate the necessary microchannels and integrate them into microfluidic platforms. In peptidomics and proteomics, microfluidics is often used in combination with mass spectrometric (MS) analysis. This review provides an overview of using microfluidic systems for peptidomics, proteomics and cell analysis. The application of microfluidics in combination with MS detection and other novel techniques to answer clinical questions is also discussed in the context of disease diagnosis and therapy. Recent developments and applications of capillary and microchip (electro)separation methods in proteomic and peptidomic analysis are summarized. The state of the art of microchip platforms for cell sorting and single-cell analysis is also discussed. Advances in detection methods are reported, and new applications in proteomics and peptidomics, quality control of peptide and protein pharmaceuticals, analysis of proteins and peptides in biomatrices and determination of their physicochemical parameters are highlighted.

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Section: The Future Of Microfluidicsmentioning

confidence: 99%

Microfluidics for Peptidomics, Proteomics, and Cell Analysis

et al. 2021

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“…Capillary action is required for long-distance passive water transport. Capillary liquid transport can occur in very small cavities, where capillary forces dominate other forces [86] . The corresponding surface structure was found in the lizard's granular skin (Fig.…”

Section: Water Transportmentioning

confidence: 99%

Bio-inspired Fog Harvesting Materials: Basic Research and Bionic Potential Applications

2021

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With the explosive growth of the world’s population and the rapid increase in industrial water consumption, the world’s water supply has fallen into crisis. The shortage of fresh water resources has become a global problem, especially in arid regions. In nature, many organisms can collect water from foggy water under harsh conditions, which provides us with inspiration for the development of new functional fog harvesting materials. A large number of bionic special wettable synthetic surfaces are synthesized for water mist collection. In this review, we introduce some water collection phenomena in nature, outline the basic theories of biological water harvesting, and summarize six mechanisms of biological water collection: increased surface wettability, increased water transmission area, long-distance water delivery, water accumulation and storage, condensation promotion, and gravity-driven. Then, the water collection mechanisms of three typical organisms and their synthesis are discussed. And their function, water collection efficiency, new developments in their biomimetic materials are narrated, which are cactus, spider and desert beetles. The study of multiple bionics was inspired by the discovery of Nepenthes’ moist and smooth peristome. The excellent characteristics of a variety of biological water collection structures, combined with each other, are far superior to other single synthetic surfaces. Furthermore, the main problems in the preparation and application of biomimetic fog harvesting materials and the future development trend of materials fog harvesting are prospected.

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“…With the microfabrication techniques initially rooted from the microelectromechanical systems (MEMS) technology, this field will gradually develop into a discipline itself. [1][2][3] The fundamental techniques for microfluidic or optofluidic device fabrication originate from the semiconductor industry and are based on silicon or glass materials. With the development of polymer-based fabrication techniques, polymer-based microfluidic devices become more prevalent with the advantages of being economic and easy to fabricate, and having material versatility and good system compatibility.…”

Section: Introductionmentioning

confidence: 99%