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Answering the question as to why we age is tantamount to answering the question of what is life itself. There are countless theories as to why and how we age, but, until recently, the very definition of aging – senescence – was still uncertain. Here, we summarize the main views of the different models of senescence, with a special emphasis on the biochemical processes that accompany aging. Though inherently complex, aging is characterized by numerous changes that take place at different levels of the biological hierarchy. We therefore explore some of the most relevant changes that take place during aging and, finally, we overview the current status of emergent aging therapies and what the future holds for this field of research. From this multi-dimensional approach, it becomes clear that an integrative approach that couples aging research with systems biology, capable of providing novel insights into how and why we age, is necessary.

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Plastic pollution is generated by the unsustainable use and disposal of plastic products in modern society, threatening economies, ecosystems, and human health. Current clean-up strategies have attempted to mitigate the negative effects of plastic pollution but are unable to compete with increasing quantities of plastic entering the environment. Thus, reducing inputs of plastic to the environment must be prioritized through a global multidisciplinary approach. Mismanaged waste is a major land-based source of plastic pollution that can be reduced through improvements in the life-cycle of plastics, especially in production, consumption, and disposal, through an Integrated Waste Management System. In this review paper, we discuss current practices to improve life cycle and waste management of plastics that can be implemented to reduce health and environmental impacts of plastics and reduce plastics pollution. Ten recommendations for stakeholders to reduce plastic pollution include (1) regulation of production and consumption; (2) eco-design; (3) increasing the demand for recycled plastics; (4) reducing the use of plastics; (5) use of renewable energy for recycling; (6) extended producer responsibility over waste; (7) improvements in waste collection systems; (8) prioritization of recycling; (9) use of bio-based and biodegradable plastics; and (10) improvement in recyclability of e-waste.

Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi, viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic agents. Due to the alarming increase of antimicrobial resistance, interest in alternative antimicrobial agents has led to the exploitation of antimicrobial peptides, both synthetic and from natural sources. Thus, many peptide-based drugs are currently commercially available for the treatment of numerous ailments, such as hepatitis C, myeloma, skin infections, and diabetes. Initial barriers are being increasingly overcome with the development of cost-effective, more stable peptides. Herein, we review the available strategies for their synthesis, bioinformatics tools for the rational design of antimicrobial peptides with enhanced therapeutic indices, hurdles and shortcomings limiting the large-scale production of AMPs, as well as the challenges that the pharmaceutical industry faces on their use as therapeutic agents.