Microfluidic sensing: state of the art fabrication and detection techniques

Wu, Jing; Gu, Miṅ

doi:10.1117/1.3607430

Cited by 167 publications

(140 citation statements)

References 166 publications

(152 reference statements)

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“…In turn, injection molding involves the high-pressure injection of pre-polymerized molten thermoplastic granules into a heated molding cavity (Mair et al, 2006;Attia et al, 2009), which allows the high-throughput industry-scale fabrication of thermoplastic devices. A detailed description of microfabrication methods of lab-on-a-chip devices can be found elsewhere (Fiorini and Chiu, 2005;Kim et al, 2008a;Coltro et al, 2010;Sollier et al, 2011;Wu and Gu, 2011).…”

Section: Fabrication Methods and Materials Of Cell Chip Systemsmentioning

confidence: 99%

“…A major advantage of lab-on-a-chip technology is that it allows the facile integration of optical, electrical, magnetic, and acoustical sensors for cell analysis (Wu and Gu, 2011). Routinely used immunofluorescence end-point analysis can now be extended with complementary, continuous monitoring techniques (Charwat et al, 2013a(Charwat et al, ,b, 2014Picher et al, 2013;Novak et al, 2015).…”

Section: Integrated Sensing Functions For Microfluidic Cell Analysis mentioning

confidence: 99%

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Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

et al. 2015

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The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of evaluating cell cultures under defined, reproducible, and standardizable measurement conditions. In the present review, we describe recent lab-on-a-chip developments for cell analysis and how these methodologies could improve standard quality control in the field of manufacturing cell-based vaccines for clinical purposes. We highlight in particular the regulatory requirements for advanced cell therapy applications using as an example dendritic cell-based cancer vaccines to describe the tangible advantages of microfluidic devices that overcome most of the challenges associated with automation, miniaturization, and integration of cell-based assays. As its main advantage, lab-on-a-chip (LoC) technology allows for precise regulation of culturing conditions, while simultaneously monitoring cell relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of cell cultures and their potential future applications for cell-based strategies for cancer immunotherapy are discussed in the present review.

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Section: Fabrication Methods and Materials Of Cell Chip Systemsmentioning

confidence: 99%

Section: Integrated Sensing Functions For Microfluidic Cell Analysis mentioning

confidence: 99%

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

et al. 2015

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“…Microfluidic channels were cast from PDMS (1:10 base to cross-linker), which was degassed at a pressure of 5 mBar for 20 min. Prior to casting PDMS over the mold, the resin surface was passivated by depositing a fluorocarbon film in a reactive-ion etcher [27][28][29] (low pressure CHF 3 for 120 s at an RF power of 45 W). PDMS was next cast onto the passivated molds and baked at 70 C for 1 h. The cured material was then peeled from the mold and sonicated for 20 min in acetone to dissolve the embedded ABS tube and thereby produce a fully 3D fluidic channel of dimensions w ¼ 500 lm, t ¼ 100 lm, and h ¼ 1:3 mm [ Fig.…”

Section: -6951/2017/111(23)/234102/5mentioning

confidence: 99%

A planar surface acoustic wave micropump for closed-loop microfluidics

Rimsa

Smith

Wälti

et al. 2017

Applied Physics Letters

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We have designed and characterized a simple Rayleigh-surface acoustic wave-based micropump, integrated directly with a fully enclosed 3D microfluidic system, which improves significantly the pumping efficiency within a coupled fluid whilst maintaining planar integration of the micropump and microfluidics. We achieve this by exploiting the Rayleigh-scattering angle of surface acoustic waves into pressure waves on contact with overlaid fluids, by designing a microfluidic channel aligned almost co-linearly with the launched pressure waves and by minimizing energy losses by reflections from, or absorption within, the channel walls. This allows the microfluidic system to remain fully enclosed—a pre-requisite for point-of-care applications—removing sources of possible contamination, whilst achieving pump efficiencies up to several orders of magnitude higher than previously reported, at low operating powers of 0.5 W.

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“…Most of these approaches use electrochemical and optical methods. However, they have several drawbacks like nonlinear detection range, lack of sensitivity, non-specific detection and complexity of integration [1][2][3]. The other approaches use mechanical and magnetic based methods.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Detection Structure for LOC Immunoassays, Multiphysics Simulations and Experimental Results

Rabehi¹,

Garlan²,

Shanehsazzadeh

et al. 2017

Proceedings of Eurosensors 2017, Paris, France, 3–6 September 2017

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Abstract:The aim of this work is to develop a completely integrated Lab-On-Chip (LOC) for easy, rapid and cost-effective immunoassays. The pathogen sensing system is composed of a microfluidic channel surrounded by planar microcoils which are responsible for the emission and the detection of magnetic fields. The system allows the detection and quantification of superparamagnetic beads used for immunoassays in a "sandwich" antigen-antibody configuration. Multiphysics simulations have been achieved and preliminary experimental results have allowed to validate the structure.

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Microfluidic sensing: state of the art fabrication and detection techniques

Cited by 167 publications

References 166 publications

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

A planar surface acoustic wave micropump for closed-loop microfluidics

Magnetic Detection Structure for LOC Immunoassays, Multiphysics Simulations and Experimental Results

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