Current advances and future perspectives of 3D printing natural-derived biopolymers

Liu, Jun; Sun, Lily; Xu, Wen Yang; Wang, Qianqian; Yu, Sujie; Sun, Jianzhong

doi:10.1016/j.carbpol.2018.11.077

Cited by 302 publications

(188 citation statements)

References 136 publications

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“…Bioinks loaded with polysaccharides and proteins (e.g., collagen, alginate) can show very different values of viscosity. The technology is mature with available bioprinters on the market at reasonable costs, which allow customization and focus on bioink mixtures [45][46][47][48][49][50][51][52][53].…”

Section: Process and Materialsmentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolution of additive manufacturing techniques provides the tools to engineer these architectures at different scales. Moreover, it is now possible to tailor their biomechanical and topological properties while taking inspiration from the characteristics of the extracellular matrix, the three-dimensional scaffold in which cells proliferate, migrate, and differentiate. In such context, there is therefore a continuous quest for synthetic and nature-derived composite materials that must hold biocompatible, biodegradable, bioactive features and also be compatible with the envisioned fabrication strategy. The structure of the current review is intended to provide to both micro-engineers and cell biologists a comparative overview of the characteristics, advantages, and drawbacks of the major 3D printing techniques, the most promising biomaterials candidates, and the trade-offs that must be considered in order to replicate the properties of natural microenvironments.

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Section: Process and Materialsmentioning

confidence: 99%

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

2019

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“…Carbohydrate polymers from natural sources have been studied and utilized in the pharmaceutical and biotechnological industries for many years. Besides its desired gelling properties, these natural polysaccharides have been used as hydrogels for 3D bioprinting [3][4][5]10,11]. For example, in the presence of divalent cations, such as calcium, anionic polysaccharides are able to form gels because of associations between the calcium ion and the acid residues.…”

Section: Overview Of Natural Anionic Polysaccharides From Plant Bactmentioning

confidence: 99%

“…The term 3D printing referred to the polymer technologies where additive manufacturing was used in metalworking. The main 3D printing categories described in literature are stereolithography (SLA), fused deposition modeling (FDM) and selective laser sintering (SLS) [3]. A fourth technique usually grouped with SLA is digital light processing (DLP).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the components of bioink must be biocompatible for avoiding adverse responses after implantation in vivo. Regarding the application of natural polysaccharides, 3D bioprinting technologies mainly involve inkjet-based printing, extrusion-based printing, light-assisted 3D printing and particle fused-based 3D printing [3]. Polysaccharides are highly complex biopolymers composed of monosaccharides (mainly hexoses and pentoses) with linear or ramified structures.…”

Section: Introductionmentioning

confidence: 99%

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Use of Anionic Polysaccharides in the Development of 3D Bioprinting Technology

et al. 2019

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Three-dimensional (3D) bioprinting technology is now one of the best ways to generate new biomaterial for potential biomedical applications. Significant progress in this field since two decades ago has pointed the way toward use of natural biopolymers such as polysaccharides. Generally, these biopolymers such as alginate possess specific reactive groups such as carboxylate able to be chemically or enzymatically functionalized to generate very interesting hydrogel structures with biomedical applications in cell generation. This present review gives an overview of the main natural anionic polysaccharides and focuses on the description of the 3D bioprinting concept with the recent development of bioprinting processes using alginate as polysaccharide.

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“…This need for mimicking the extracellular matrix (ECM) has driven the design of novel biomaterials and fabrication techniques. The readers are encouraged to refer to some of the recent reviews on this topic [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering

Hanumantharao

Rao

2019

Fibers

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Electrospinning and polymer blending have been the focus of research and the industry for their versatility, scalability, and potential applications across many different fields. In tissue engineering, nanofiber scaffolds composed of natural fibers, synthetic fibers, or a mixture of both have been reported. This review reports recent advances in polymer blended scaffolds for tissue engineering and the fabrication of functional scaffolds by electrospinning. A brief theory of electrospinning and the general setup as well as modifications used are presented. Polymer blends, including blends with natural polymers, synthetic polymers, mixture of natural and synthetic polymers, and nanofiller systems, are discussed in detail and reviewed.

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Current advances and future perspectives of 3D printing natural-derived biopolymers

Cited by 302 publications

References 136 publications

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Engineered 3D Polymer and Hydrogel Microenvironments for Cell Culture Applications

Use of Anionic Polysaccharides in the Development of 3D Bioprinting Technology

Multi-Functional Electrospun Nanofibers from Polymer Blends for Scaffold Tissue Engineering

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