Curcumin-stabilized silver nanoparticles encapsulated in biocompatible electrospun nanofibrous scaffold for sustained eradication of drug-resistant bacteria

Cai, Ling; Zhu, Xinyi; Ruan, Hongjie; Yang, Jing; Wei, Wei; Wu, Yuan; Zhou, Liuzhu; Jiang, Huijun; Ji, Minghui; Chen, Jin

doi:10.1016/j.jhazmat.2023.131290

Cited by 28 publications

(11 citation statements)

References 45 publications

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“…Many ribosomal protein-related genes were significantly upregulated after being treated with SNM except rpsA (Table S1), which could be attributed to the inhibitory effect of gentamicin sulfate on bacterial protein synthesis through biochemically binding to the ribosomes . PTS-related genes were also found to be significantly downregulated after exposed to SNM (Table S1), which might be ascribed to the released silver from SNM . The decreased expression of the PTS sugar transporter subunits (EIIA and EIIB) inhibited the carbohydrate and energy metabolism of MRSA , which further resulted in reduced bacterial activity.…”

Section: Resultsmentioning

confidence: 99%

“…55 PTS-related genes were also found to be significantly downregulated after exposed to SNM (Table S1), which might be ascribed to the released silver from SNM. 56 The decreased expression of the PTS sugar transporter subunits (EIIA and EIIB) inhibited the carbohydrate and energy metabolism of MRSA, which further resulted in reduced bacterial activity.…”

Section: Transcriptomic Analysis Of Snm-treated Mrsamentioning

confidence: 99%

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Encapsulating Antibiotic and Protein-Stabilized Nanosilver into Sandwich-Structured Electrospun Nanofibrous Scaffolds for MRSA-Infected Wound Treatment

Cai,

Zhang,

Yang

et al. 2023

ACS Appl. Mater. Interfaces

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With the increasing prevalence of microbial infections, which results in prolonged inflammation and delayed wound healing, the development of effective and safe antimicrobial wound dressings of multiple properties remains challenging for public health. Despite their various formats, the available developed dressings with limited functions may not fulfill the diverse demands involved in the complex wound healing process. In this study, multifunctional sandwich-structured electrospinning nanofiber membranes (ENMs) were fabricated. According to the structural composition, the obtained ENMs included a hydrophilic inner layer loaded with curcumin and gentamicin sulfate, an antibacterial middle layer consisting of bovine serum albumin stabilized silver oxide nanoparticles, and a hydrophobic outer layer. The prepared sandwich-structured ENMs (SNM) exhibited good biocompatibility and killing efficacy on Escherichia coli, Staphylococcus aureus, and Methicillin-resistant S. aureus (MRSA). In particular, transcriptomic analysis revealed that SNM inactivated MRSA by inhibiting its carbohydrate and energy metabolism and reduced the bacterial resistance by downregulating mecA. In the animal experiment, SNM showed improved wound healing efficiency by reducing the bacterial load and inflammation. Moreover, 16S rDNA sequencing results indicated that SNM treatment may accelerate wound healing without observed influence on the normal skin flora. Therefore, the constructed sandwich-structured ENMs exhibited promising potential as dressings to deal with the infected wound management.

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Section: Resultsmentioning

confidence: 99%

Section: Transcriptomic Analysis Of Snm-treated Mrsamentioning

confidence: 99%

Encapsulating Antibiotic and Protein-Stabilized Nanosilver into Sandwich-Structured Electrospun Nanofibrous Scaffolds for MRSA-Infected Wound Treatment

Cai,

Zhang,

Yang

et al. 2023

ACS Appl. Mater. Interfaces

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“…40,41 The presence of a thick peptidoglycan layer of the cell wall in Gram-positive bacteria prevents the penetration of metals in the structure of MOFs into bacteria cells. [42][43][44][45] The major factor affecting the antibacterial activity of MOFs is the ease of release of metal ions. The antibacterial effect of MOFs is due to the presence of metal ions but also due to the antibacterial action of organic linkers.…”

Section: Biological Studiesmentioning

confidence: 99%

PEGylation of a shell over core–shell MOFs—a novel strategy for preventing agglomeration and synergism in terms of physicochemical and biological properties

Pillai,

K.,

Rhee

et al. 2023

J. Mater. Chem. B

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“…10 Another useful antibacterial therapy is chemotherapy by silver nanoparticles (Ag NPs), which have been proved to be effective antimicrobial agents with broadspectrum antimicrobial activity and are not likely to develop drug-resistance. 11,12 However, the easy self-aggregation and the hard recovery of Ag NPs severely limit their biomedical applications. 13 Therefore, it is of significance to fabricate antibacterial agents consisting of photoresponsive materials and Ag NPs to realize chemical−photodynamic synergistic therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Although various organic photosensitizers (e.g., porphyrin and phthalocyanine) and nanophotosensitizers (e.g., metal oxide nanoparticles, quantum dots, carbon dots, and semiconductors) , have been extensively exploited as antimicrobial agents via aPDT, the ROS generation efficiency is still not satisfactory, largely hampering the board applicability of aPDT in clinical treatments . Another useful antibacterial therapy is chemotherapy by silver nanoparticles (Ag NPs), which have been proved to be effective antimicrobial agents with broad-spectrum antimicrobial activity and are not likely to develop drug-resistance. , However, the easy self-aggregation and the hard recovery of Ag NPs severely limit their biomedical applications . Therefore, it is of significance to fabricate antibacterial agents consisting of photoresponsive materials and Ag NPs to realize chemical–photodynamic synergistic therapy.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

Zhan,

Zeng,

et al. 2023

Inorg. Chem.

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The abuse of antibiotics leads to an increasing emergence of drug-resistant bacteria, which not only causes a waste of medical resources but also seriously endangers people's health and life safety. Therefore, it is highly desirable to develop an efficient antibacterial strategy to reduce the reliance on traditional antibiotics. Antibacterial photodynamic therapy (aPDT) is regarded as an intriguing antimicrobial method that is less likely to generate drug resistance, but its efficiency still needs to be further improved. Herein, a robust titanium-based metal−organic framework ACM-1 was adopted to support Ag nanoparticles (NPs) to obtain Ag NPs@ACM-1 for boosting antibacterial efficiency via synergistic chemical−photodynamic therapy. Apart from the intrinsic antibacterial nature, Ag NPs largely boost ROS production and thus improve aPDT efficacy. As a consequence, Ag NPs@ACM-1 shows excellent antibacterial activity under visible light illumination, and its minimum bactericidal concentrations (MBCs) against E. coli, S. aureus, and MRSA are as low as 39.1, 39.1, and 62.5 μg mL −1 , respectively. Moreover, to expand the practicability of Ag NPs@ACM-1, two (a dense and a loose) Ag NPs@ ACM-1 films were readily fabricated by simply dispersing Ag NPs@ACM-1 into heated aqueous solutions of edible agar and sequentially cooling through heating or freeze-drying, respectively. Notably, these two films are mechanically flexible and exhibit excellent antibacterial activities, and their antimicrobial performances can be well retained in their recyclable and remade films. As agar is nontoxic, degradable, inexpensive, and ecosustainable, the dense and loose Ag NPs@ACM-1 films are potent to serve as recyclable and degradable antibacterial plastics and antibacterial dressings, respectively.

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Curcumin-stabilized silver nanoparticles encapsulated in biocompatible electrospun nanofibrous scaffold for sustained eradication of drug-resistant bacteria

Cited by 28 publications

References 45 publications

Encapsulating Antibiotic and Protein-Stabilized Nanosilver into Sandwich-Structured Electrospun Nanofibrous Scaffolds for MRSA-Infected Wound Treatment

Encapsulating Antibiotic and Protein-Stabilized Nanosilver into Sandwich-Structured Electrospun Nanofibrous Scaffolds for MRSA-Infected Wound Treatment

PEGylation of a shell over core–shell MOFs—a novel strategy for preventing agglomeration and synergism in terms of physicochemical and biological properties

Silver Nanoparticle-Loaded Titanium-Based Metal–Organic Framework for Promoting Antibacterial Performance by Synergistic Chemical–Photodynamic Therapy

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