PEGylation of a shell over core–shell MOFs—a novel strategy for preventing agglomeration and synergism in terms of physicochemical and biological properties

Abstract

The present work demonstrates a new strategy of PEGylation over a core shell MOFs of HKUST-1 and Cu-MOF-2 by solvothermal method. The novel synthesized PEGylated core shells MOFs have a...

Synergistic Antifungal Activity of Dialdehyde Chitosan Loaded with Copper Metal‐Organic Framework (Cu‐MOF)

“…In Cu-MOF (Figure 9), the degradation stage around 25-200 °C was due to the loss of about 0.89 % crystalline water and about 8.28 % small molecules, [33] while losses in the regions of 200 to ~250 °C and ~325 to ~375 °C were due to the loss of about 7.08 % of coordinated DMF molecules [49,41] and about 23.21 % framework respectively. [53] The great weight loss of about 31.33 % above 400 °C was due to the formation of CuÀ O as residual degradation products. [35] Compared with Cu-MOF in Figure 9, there was a great weight loss of approximately 31.51 % in Cu-MOF-OCs TGA thermograms (Figure 10) around ~200 to ~300 °C representing the degradation of intramolecular and intermolecular hydrogen bonds of OCs.…”

“…Increased Cu 2 + chelation caused more π electron delocalization and partial sharing of Cu 2 + with the donor groups resulting in decreased metal ion polarity. [56,53] Copper ions are thought to catalyze the generation of reactive oxygen species (ROS) through Fenton-like reactions, wherein Cu 2 + is reduced to Cu + by cellular components, leading to the production of hydroxyl radicals. Thus, the formation of hydrogen bonds with the carbonyl portion of the Cu-MOF-OCs and the fungal cell membrane compromises fungal cell membrane integrity and interferes with cell wall synthesis resulting in cell fatality.…”