2022
DOI: 10.1590/s2175-97902022e18946
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Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties

Abstract: To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@RLPO) showed deep red, golden orange and reddish orange color, respectively. Cur@RSPO entrapped 15.

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Cited by 5 publications
(5 citation statements)
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References 43 publications
(47 reference statements)
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“…The obtained results confirm that Eudragits are suitable polymers for achieving the amorphous state of the drug, which is consistent in the literature. The completely amorphous "halo" of the X-ray diffraction patterns in compound-Eudragit systems were also observed by Chenchen et al [15], Wang et al [40], Zong et al [14], and Alsayad et al [41]. In addition, evidence was provided that the use of PCA together with FT-IR spectroscopy is an effective technique for confirming the amorphous state of KMPs.…”
Section: Resultsmentioning
confidence: 58%
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“…The obtained results confirm that Eudragits are suitable polymers for achieving the amorphous state of the drug, which is consistent in the literature. The completely amorphous "halo" of the X-ray diffraction patterns in compound-Eudragit systems were also observed by Chenchen et al [15], Wang et al [40], Zong et al [14], and Alsayad et al [41]. In addition, evidence was provided that the use of PCA together with FT-IR spectroscopy is an effective technique for confirming the amorphous state of KMPs.…”
Section: Resultsmentioning
confidence: 58%
“…Liu et al [51] proposed a peak shift around 1700 cm −1 (C=O), confirming hydrogen bonding between the carbonyl group of EPO and the hydroxyl group of the drug. Similarly, Zong et al [14] proposed that the ASD of curcumin with Eudragit RS PO and Eudragit RL PO formed a hydrogen bond between the -OH group of curcumin and the C=O group of the polymer. Furthermore, for the curcumin-EPO ASD, the authors suggested that curcumin may donate one hydrogen to the dimethylaminoethyl methacrylate group of Eudragit EPO [14].…”
Section: Mass (Mg)mentioning
confidence: 97%
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“…The grid box was centered around the active site pocket, as predicted by PrankWeb. As predicted by PrankWeb, the AchE active site contained TYR 68 , ASP 70 , TYR 73 , THR 79 , TRP 82 , ASN 83 , GLY 116 , GLY 117 , GLY 118 , TYR 120 , SER 121 , GLY 122 , LEU 126 , GLU 198 , SER 199 , TRP 282 , LEU 285 , SER 289 , PHE 291 , ARG 292 , PHE 293 , TYR 333 , PHE 334 , TYR 337 , TRP 435 , HIS 443 , GLY 444 , and TYR 445 . The BChE's active pocket contained: ASP 67 , GLY 75 , SER 76 , TRP 79 , ASN 80 , GLY 112 , GLY 113 , GLY 114 , GLN 116 , THR 117 , GLY 118 , TYR 125 , GLU 194 , SER 195 , TRP 228 , PRO 282 , LEU 283 , SER 284 , VAL 285 , ALA 325 , PHE 326 , TYR 329 , PHE 393 , TRP 425 , HIS 433 , GLY 434 , and TYR 435 .…”
Section: Molecular Docking Studysupporting
confidence: 54%
“…Previously, the fully amorphous "halo" in X-ray patterns was observed in binary Eudragit ® systems reported by Wang et al [59], Alsayad et al [66], Chenchen et al [67], and Zong et al [68]. In another study, XRPD confirmed the amorphous state of curcumin [69], daidzein [50], genistein [51,70], hesperidin [42], pterostilbene [43,71], quercetin [41,72], and resveratrol [73] ASDs.…”
Section: Resultsmentioning
confidence: 71%