Curcumin solid dispersion based on three model acrylic polymers: formulation and release properties

Abstract

To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@RLPO) showed deep red, golden orange and reddish orange color, respectively. Cur@RSPO entrapped 15.

The Study of Amorphous Kaempferol Dispersions Involving FT-IR Spectroscopy

“…The obtained results confirm that Eudragits are suitable polymers for achieving the amorphous state of the drug, which is consistent in the literature. The completely amorphous "halo" of the X-ray diffraction patterns in compound-Eudragit systems were also observed by Chenchen et al [15], Wang et al [40], Zong et al [14], and Alsayad et al [41]. In addition, evidence was provided that the use of PCA together with FT-IR spectroscopy is an effective technique for confirming the amorphous state of KMPs.…”

“…Liu et al [51] proposed a peak shift around 1700 cm −1 (C=O), confirming hydrogen bonding between the carbonyl group of EPO and the hydroxyl group of the drug. Similarly, Zong et al [14] proposed that the ASD of curcumin with Eudragit RS PO and Eudragit RL PO formed a hydrogen bond between the -OH group of curcumin and the C=O group of the polymer. Furthermore, for the curcumin-EPO ASD, the authors suggested that curcumin may donate one hydrogen to the dimethylaminoethyl methacrylate group of Eudragit EPO [14].…”

“…Transforming the crystalline polyphenol into an amorphous form significantly enhances the dissolution rate and solubility, resulting in improved absorption and therapeutic effects. The amorphous matrix provides stability and prevents the polyphenol from reverting to its crystalline form, ensuring sustained supersaturation and improved drug release [9][10][11][12]14,15]. Obtaining ASD can be achieved through various techniques such as hot melt extrusion [11], spray drying [16,17], solvent evaporation [18], and ball milling [9,10,19].…”

Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity

“…The grid box was centered around the active site pocket, as predicted by PrankWeb. As predicted by PrankWeb, the AchE active site contained TYR 68 , ASP 70 , TYR 73 , THR 79 , TRP 82 , ASN 83 , GLY 116 , GLY 117 , GLY 118 , TYR 120 , SER 121 , GLY 122 , LEU 126 , GLU 198 , SER 199 , TRP 282 , LEU 285 , SER 289 , PHE 291 , ARG 292 , PHE 293 , TYR 333 , PHE 334 , TYR 337 , TRP 435 , HIS 443 , GLY 444 , and TYR 445 . The BChE's active pocket contained: ASP 67 , GLY 75 , SER 76 , TRP 79 , ASN 80 , GLY 112 , GLY 113 , GLY 114 , GLN 116 , THR 117 , GLY 118 , TYR 125 , GLU 194 , SER 195 , TRP 228 , PRO 282 , LEU 283 , SER 284 , VAL 285 , ALA 325 , PHE 326 , TYR 329 , PHE 393 , TRP 425 , HIS 433 , GLY 434 , and TYR 435 .…”

“…Previously, the fully amorphous "halo" in X-ray patterns was observed in binary Eudragit ® systems reported by Wang et al [59], Alsayad et al [66], Chenchen et al [67], and Zong et al [68]. In another study, XRPD confirmed the amorphous state of curcumin [69], daidzein [50], genistein [51,70], hesperidin [42], pterostilbene [43,71], quercetin [41,72], and resveratrol [73] ASDs.…”