2023
DOI: 10.3390/ijms242417155
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The Study of Amorphous Kaempferol Dispersions Involving FT-IR Spectroscopy

Natalia Rosiak,
Ewa Tykarska,
Judyta Cielecka-Piontek

Abstract: Attenuated total reflection-Mid-Fourier transform-infrared (ATR-Mid-FT-IR) spectroscopy combined with principal component analysis (PCA) has been applied for the discrimination of amorphous solid dispersion (ASD) of kaempferol with different types of Eudragit (L100, L100-55, EPO). The ASD samples were prepared by ball milling. Training and test sets for PCA consisted of a pure compound, physical mixture, and incomplete/complete amorphous solid dispersion. The obtained results confirmed that the range 400–1700 … Show more

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Cited by 3 publications
(7 citation statements)
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“…The grid box was centered around the active site pocket as predicted by PrankWeb. As predicted by PrankWeb, the AchE active site contained TYR 68 , ASP 70 , TYR 73 , THR 79 , TRP 82 , ASN 83 , GLY 116 , GLY 117 , GLY 118 , TYR 120 , SER 121 , GLY 122 , LEU 126 , GLU 198 , SER 199 , TRP 282 , LEU 285 , SER 289 , PHE 291 , ARG 292 , PHE 293 , TYR 333 , PHE 334 , TYR 337 , TRP 435 , HIS 443 , GLY 444 , TYR 445 . While the BChE's active pocket contained: ASP 67 , GLY 75 , SER 76 , TRP 79 , ASN 80 , GLY 112 , GLY 113 , GLY 114 , GLN 116 , THR 117 , GLY 118 , TYR 125 , GLU 194 , SER 195 , TRP 228 , PRO 282 , LEU 283 , SER 284 , VAL 285 , ALA 325 , PHE 326 , TYR 329 , PHE 393 , TRP 425 , HIS 433 , GLY 434 , TYR 435 .…”
Section: Physical Stabilitysupporting
confidence: 52%
See 1 more Smart Citation
“…The grid box was centered around the active site pocket as predicted by PrankWeb. As predicted by PrankWeb, the AchE active site contained TYR 68 , ASP 70 , TYR 73 , THR 79 , TRP 82 , ASN 83 , GLY 116 , GLY 117 , GLY 118 , TYR 120 , SER 121 , GLY 122 , LEU 126 , GLU 198 , SER 199 , TRP 282 , LEU 285 , SER 289 , PHE 291 , ARG 292 , PHE 293 , TYR 333 , PHE 334 , TYR 337 , TRP 435 , HIS 443 , GLY 444 , TYR 445 . While the BChE's active pocket contained: ASP 67 , GLY 75 , SER 76 , TRP 79 , ASN 80 , GLY 112 , GLY 113 , GLY 114 , GLN 116 , THR 117 , GLY 118 , TYR 125 , GLU 194 , SER 195 , TRP 228 , PRO 282 , LEU 283 , SER 284 , VAL 285 , ALA 325 , PHE 326 , TYR 329 , PHE 393 , TRP 425 , HIS 433 , GLY 434 , TYR 435 .…”
Section: Physical Stabilitysupporting
confidence: 52%
“…It provides information about the presence of specific bonds and interactions between the polymer and other components in the dispersion. This analysis helps assess the drug–polymer compatibility and potential interactions that may influence the stability and performance of the ASD formulation [ 46 , 50 , 54 , 59 , 70 ]. In this study, infrared spectroscopy was used to demonstrate potential interactions between MYR and PVP30.…”
Section: Resultsmentioning
confidence: 99%
“…Consequently, the Tg of PTR was ascertained through the melting and cooling method within a DSC oven, and this value was employed in the G-T and C-K equations (XRPD analysis confirmed the amorphous state of melted PTR). The same approach was used by Löbmann et al for carbamazepine [ 77 ], Rosiak et al for hesperidin and kaempferol [ 52 , 60 ], Wdowiak et al for curcumin, hesperetin, and piperine [ 50 , 70 ], and Garbiec et al for genistein [ 78 ].…”
Section: Resultsmentioning
confidence: 99%
“…They are prepared by dispersing the active substance in a carrier, usually a pharmacologically inert polymer. Techniques such as hot melt extrusion [ 50 ], solvent evaporation [ 51 ], ball milling [ 52 ], spray drying [ 53 ], supercritical carbon dioxide extraction [ 54 ], and freeze drying [ 55 ] are used to obtain the ASDs of polyphenols. Due to the thermodynamic instability of amorphous drugs, their recrystallization may occur during storage.…”
Section: Introductionmentioning
confidence: 99%
“…The preparation of ASDs of polyphenols involves various techniques, including spray drying [41], ball milling [42,43], cryomilling [44], hot-melt extrusion [45], and freeze-drying [46]. To date, it has been possible to obtain ASDs of such polyphenols as: apigenin [47], baicalein [48], chrysin [49], daidzein [50], FIS [24], genistein [51], kaempferol [52], naringenin [53], pterostilbene [43], quercetin [54][55][56], resveratrol [57]. Our previous research on FIS also focused on obtaining ASDs via co-precipitation in a supercritical carbon dioxide environment [24].…”
Section: Introductionmentioning
confidence: 99%