Green and single-step simultaneous composite starch aerogel formation-high bioavailability curcumin particle formation

Alavi, Farhad; Ciftci, Ozan N.

doi:10.1016/j.ijbiomac.2024.129945

Cited by 1 publication

(1 citation statement)

References 35 publications

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“…Moreover, a green single-step simultaneous aerogel formation-curcumin deposition method was applied to impregnate curcumin into the aerogels through supercritical carbon dioxide (SC-CO 2 ) drying technology. The loading of curcumin in aerogels also significantly enhanced the bioaccessibility of curcumin in the simulated gastrointestinal fluid by almost 30-fold when compared to the unloaded curcumin [96]. Based on the current knowledge, the encapsulation of curcumin into nanoparticles seems to be the most promising formulation to effectively increase its bioaccessibility and bioavailability.…”

Section: Discussionmentioning

confidence: 97%

Curcumin as a Multifunctional Spice Ingredient against Mental Disorders in Humans: Current Clinical Studies and Bioavailability Concerns

Spanoudaki,

Papadopoulou,

Antasouras

et al. 2024

Life

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Background: Mental disorders in terms of depression, anxiety, and stress are one of the major causes of burden globally. Over the last two decades, the use of plant-based substances in the treatment of mental disorders in combination or not with medication has increasingly attracted the interest of the scientific research community. However, even if there is a plethora of naturally occurring bioactive compounds, most of them have low bioavailability, rendering them unable to insert into the bloodstream to exert their biological activities. Methods: This is a comprehensive narrative review that critically summarizes and scrutinizes the new approaches to the treatment of mental disorders using curcumin, also highlighting its bioavailability properties. The most accurate were searched using effective and relevant keywords. Results: This narrative review reveals substantial evidence that curcumin can exert significant effects on several mental disorders. However, despite the low cost, the extensive and confirmed potency of curcumin and its involvement in signaling pathways and the scientifically confirmed data regarding its molecular mechanisms of action against mental disorders, this naturally occurring compound presents low oral bioavailability. Pharmaceutical technology has provided solutions to increase the bioavailability of curcumin. Combination with piperine, galactomannosides, liposomal formulation or nanoformulation overcomes the bioavailability and solubility disadvantages. Conclusions: Although curcumin demonstrates anti-anxiety, anti-depressive and anti-stress properties, studies on humans are limited and heterogeneous. Further research is highly recommended to determine the most functional formula, dose, duration, and possible side effects of curcumin on mental disorders in humans. Based on the current knowledge, the curcumin nanoformulation and Theracurmin, a form of colloidal submicroscopic particles, seem to be the most effective bioavailable formulations, which may be examined in future clinical human studies.

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Section: Discussionmentioning

confidence: 97%