Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial

Ferguson, Jessica J. A.; Stojanovski, Elizabeth; MacDonald‐Wicks, Lesley; Garg, Manohar L.

doi:10.1016/j.metabol.2017.12.009

Cited by 70 publications

(53 citation statements)

References 49 publications

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“…In combination with black seeds, reduced BF%, TC, TG, LDL, CRP, and raised HDL were recorded in the serum of the participants [154]. Similar positive effects were found in clinical trials (3 studies: 1) n = 75; 2) n = 240 and 3) n = 70) on hypocholesterolemic patients, those with type II diabetes and acute coronary syndrome [11,13,15].…”

Section: Clinical Studiessupporting

confidence: 54%

“…Many clinical trials confirmed beneficial effects of CUR in the prevention and treatment of various CV conditions. Cholesterol-lowering effect of CUR consumption has been demonstrated in many studies, where healthy subjects [12,14,56] or participants with hypercholesterolemia [15,148] consumed CUR for defined period of time (per os), ranging from 7 days to 6 months. It was found that when healthy subjects consumed CUR in doses from 80-4000 mg/day, positive effect on blood lipid profiles were observed and included decrease in SLP, lowering in TC [12,14,56] and LDL cholesterol, increase in HDL and Apo B [56,148].…”

Section: Clinical Studiesmentioning

confidence: 99%

“…This effect is attributable to inhibition of cardiomyocyte Due to CUR chemical characteristics, it is considered to be a potent anti-inflammatory phytochemical that can interact with different inflammatory pathways that generated wide range pre-clinical and clinical therapeutic potentials for CUR [9,10]. In the past decade, a growing interest was noticed in CUR-based therapies in prophylaxis and treatment for different diseases, including CVD (atherosclerosis, diabetic cardiomyopathy, arrhythmia, hypertrophic cardiomyopathy, and heart failure) [11][12][13][14][15][16][17][18][19], cancer (colon cancer, breast cancer, and multiple myeloma) [20][21][22][23][24][25][26][27], neurodegenerative diseases (Parkinson's, Alzheimer's disease, and multiple sclerosis) [8,[28][29][30], autoimmune diseases (osteoarthritis and rheumatoid arthritis) [31,32], psychological disorders [33][34][35][36][37], diabetes [38][39][40], pulmonary diseases [41][42][43], gastrointestinal disorders (gastric ulcers, indigestion, and dyspepsia) [44][45][46][47][48], ophthalmic disorders…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

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Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre-and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.

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Section: Clinical Studiessupporting

confidence: 54%

Section: Clinical Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Salehi

Prado-Audelo

Cortés

et al. 2020

JCM

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“…Sağlıklı bireylerde randomize kontrollü çalışmalarda, kurkuminler, obezite ve dislipidemisi olan hastalar ve diyabetli olanlarda plazma trigliserid düzeylerini etkin bir şekilde düşürmüştür. [24][25][26] Trigliserid düşürücü etkilerine ek olarak, kurkuminlerin hepatik yağ birikimini azalttığı ve lipojenik faktörleri aşağı regüle ederek steatozu önlediği (sterol düzenleyici element bağlayıcı protein-1, yağ asidi sentazı, asetil-CoA karboksilaz, asil koenzim A: kolesterol asiltransferaz, 3-hidroksi-3-metilglutaril-koenzim A redüktaz) ve karaciğerde adenozin monofosfat ile aktive olan protein kinaz sinyalini aktive ettiği saptanmıştır. 27 Kurkuminler ayrıca, sistemik inflamasyonun biyobelirteçlerini (CRP ve NF-κB ile ilişkili sitokinler), hepatosit hasarını ve oksidatif stresi azaltmakta, insülin duyarlılığını ve glisemik kontrolü geliştirmektedir.…”

Section: Di̇sli̇pi̇demi̇ler Ve Kurkumi̇n İli̇şki̇si̇unclassified

Effects of Curcumin on Metabolic Syndrome Components

Ergün¹,

Urhan²

2019

Turkiye Klinikleri J Cardiovasc Sci

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Ö ÖZ ZE ET T Kurkumin, zerdeçal olarak bilinen Curcuma longa isimli bitkinin köklerinden elde edilmektedir. Kurkuminin glikoliz aktivasyonu, hepatik glukoneogenezin inhibisyonu ve lipit metabolizmasının azaltılması yoluyla glukoz homeostazına aracılık etmektedir. Nükleer faktör-kappa B inhibitörü olan kurkumin insülin direncinin hafifletilmesinde yardımcıdır; peroksizom proliferatörü aktive reseptör gamayı aktive ederek hipoglisemik etkiler göstermekte ve böylece kan glukoz seviyelerindeki artışları baskılayabilmektedir. Kurkuminin insülin sekresyonu üzerinde bir etkiye sahip olabileceğini gösteren çalışmalar mevcuttur. Arterlerdeki Ang II Tip-1 reseptörü ekspresyonunu düzenleyerek metabolik sendromun önemli bileşenlerinden biri olan hipertansiyon gelişimini önleyebilmektedir. Kurkuminlerin trigliserid düşürücü etkileri çeşitli deneysel çalışmalarda doğrulanmıştır. Trigliserid sentezini düşüren ve yağ asidi oksidasyonunu artıran lipit metabolizması üzerindeki etkisine ek olarak, kurkuminin bazal metabolik hızı ve bazı sitokinlerin salınımını artırarak vücut ağırlığını da azaltabileceğini gösteren kanıtlar bulunmaktadır. Kurkuminlerin hepatik yağ birikimini azalttığı ve lipojenik faktörleri aşağı regüle ederek steatozu önlediği saptanmıştır. Ayrıca, sistemik inflamasyonun biyobelirteçlerini, hepatosit hasarını ve oksidatif stresi azaltmakta, insülin duyarlılığını ve glisemik kontrolü geliştirmektedir. Kurkumin, hepatik enzimler HMG-CoA redüktaz ve açil CoA kolesterol açiltransferazı baskılayarak hepatik kolesterol ve total kolesterol seviyelerini düşürmektedir. Ek olarak, hepatik yağlı asit sentaz aktivitesini inhibe etmekte ve yağ asitlerinin beta oksidasyonunu artırmaktadır. Kurkuminin metabolik sendromun neden olduğu parametreleri düzelterek ve olumsuz etkilerini ortadan kaldırarak metabolik sendromun tedavisinde umut verici bir ajan olduğu düşünülmektedir.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Kurkumin; metabolik sendrom; diabetes mellitus; hipertansiyon A AB BS S T TR RA AC CT T Curcumin is derived from the roots of the plant Curcuma longa known as turmeric. Curcumin mediates glucose homeostasis through activation of glycosis, inhibition of hepatic gluconeogenesis and reducing lipid metabolism. As a nuclear factor kappa B inhibitor, curcumin helps to alleviate insulin resistance; activates peroxisome proliferator-activated receptor gamma and shows hypoglycemic effects and thus suppresses increases in blood glucose levels. There are studies showing that curcumin may have an effect on insulin secretion. By regulating the expression of the Ang II Type-1 receptor in the arteries, it can prevent the development of hypertension, an important component of the metabolic syndrome. The triglyceride-lowering effects of curcumin were confirmed in various experimental studies. In addition to the effects on the lipid metabolism, there is some evidence that curcumin can reduce body weight by increasing the basal metabolic rate and release of some cytokines. Curcumin was found to reduce hepatic fat accumula...

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“…High cholesterol concentrations are related to numerous diseases, [1,2] which justifies the need to continually develop methods for the analysis of this biomolecule. The determination of cholesterol is routinely performed spectrophotometrically, [3][4][5][6] but the implementation of electrochemical cholesterol biosen-sors is of paramount importance to advance towards device portability with the added advantage of real-time monitoring and suitability for miniaturization.…”

Section: Introductionmentioning

confidence: 99%

Bimetallic Co²⁺ and Mn²⁺ Hexacyanoferrate for Hydrogen Peroxide Electrooxidation and Its Application in a Highly Sensitive Cholesterol Biosensor

et al. 2019

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In this work, we report the synthesis and characterization of a bimetallic Prussian blue analogue containing Co and Mn as outer-sphere metals (CoMnHCF). The material was a solid solution and its characterization revealed a chemical composition of Co 2.05 Mn 0.95 [Fe(CN) 6 ] 2 · 12H 2 O. The electrochemistry of this novel material showed the existence of two redox waves displaying quasi-reversible kinetics, as expressed by the larger peak-to-peak separation upon increasing the potential sweep rate. Interestingly, the CoMnHCF solid exhibited high electrocatalytic activity for the oxidation of hydrogen peroxide, thus representing an appealing scaffold for the construction of biosensors. As a proof of concept, cholesterol oxidase was immobilized at the electrode surface by using a sol-gel method, and the cyclic voltammograms were recorded at increasing concentrations of cholesterol. The biosensor showed a detection limit of 30 μM and two linear ranges with excellent sensitivity of 385 mA cm À 2 M À 1 between 50 and 150 μM, and an adequate sensitivity of 80 mA cm À 2 M À 1 between 150 and 1 mM. To the best of our knowledge, this is the first biosensor application of a pre-synthesized bimetallic hexacyanometallate, thus exploiting its potential as an H 2 O 2 electrooxidation catalyst.

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Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial

Cited by 70 publications

References 49 publications

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Effects of Curcumin on Metabolic Syndrome Components

Bimetallic Co²⁺ and Mn²⁺ Hexacyanoferrate for Hydrogen Peroxide Electrooxidation and Its Application in a Highly Sensitive Cholesterol Biosensor

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Curcumin potentiates cholesterol-lowering effects of phytosterols in hypercholesterolaemic individuals. A randomised controlled trial

Cited by 70 publications

References 49 publications

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

Effects of Curcumin on Metabolic Syndrome Components

Bimetallic Co2+ and Mn2+ Hexacyanoferrate for Hydrogen Peroxide Electrooxidation and Its Application in a Highly Sensitive Cholesterol Biosensor

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Bimetallic Co²⁺ and Mn²⁺ Hexacyanoferrate for Hydrogen Peroxide Electrooxidation and Its Application in a Highly Sensitive Cholesterol Biosensor