Prussian blue and its analogs (PBA) form an attractive family of materials for sensing and biosensing applications. Due to their open framework structure their electrochemical behavior is closely linked to the intercalation of alkaline ions. Moreover, these compounds show a clear peroxidase activity that makes them excellent transducers in biosensors based on H 2 O 2 quantification. In this review, we present in a progressive manner an overview of the structure, composition, and synthesis of PBA. Subsequently we approach the current trends in the use of PBA in the field of electrochemical sensors, providing a critical discussion on their electrochemical behavior and the electrocatalytic activity toward H 2 O 2 electrooxidation and electroreduction, along with the determination of toxic, hazardous compounds and drugs.

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