Curcumin nanospheres and nanorods: Synthesis, characterization and anticancer activity

Rajasekar, Arvindganth; Devasena, T; Suresh, Subramaniyam; Senthil, Bakthavachalam; Sivaramakrishnan, Ramachandran

doi:10.1016/j.procbio.2021.12.007

Cited by 11 publications

(5 citation statements)

References 29 publications

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“…At 180.55 °C, pure curcumin’s melting endothermic peak was observed that complied with similar findings [ 49 , 50 ]. Moreover, other formula excipients like lipids, ethanol, poloxamer 188, and tween 80 showed a thermogram that proves the compatibility of curcumin with all excipients used for the formulation.…”

Section: Resultssupporting

confidence: 88%

Development of Computational In Silico Model for Nano Lipid Carrier Formulation of Curcumin

2023

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The oral delivery system is very important and plays a significant role in increasing the solubility of drugs, which eventually will increase their absorption by the digestive system and enhance the drug bioactivity. This study was conducted to synthesize a novel curcumin nano lipid carrier (NLC) and use it as a drug carrier with the help of computational molecular docking to investigate its solubility in different solid and liquid lipids to choose the optimum lipids candidate for the NLCs formulation and avoid the ordinary methods that consume more time, materials, cost, and efforts during laboratory experiments. The antiviral activity of the formed curcumin–NLC against SARS-CoV-2 (COVID-19) was assessed through a molecular docking study of curcumin’s affinity towards the host cell receptors. The novel curcumin drug carrier was synthesized as NLC using a hot and high-pressure homogenization method. Twenty different compositions of the drug carrier (curcumin nano lipid) were synthesized and characterized using different physicochemical techniques such as UV–Vis, FTIR, DSC, XRD, particle size, the zeta potential, and AFM. The in vitro and ex vivo studies were also conducted to test the solubility and the permeability of the 20 curcumin–NLC formulations. The NLC as a drug carrier shows an enormous enhancement in the solubility and permeability of the drug.

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Section: Resultssupporting

confidence: 88%

Development of Computational In Silico Model for Nano Lipid Carrier Formulation of Curcumin

2023

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“…This so-called protein crown changes the original physicochemical characteristics of the nanoparticle and generates a new interface that defines the "biological identity" of the nanoparticle [74,75]. In addition, studies reveal that nanoparticles with a negative surface charge show greater cellular internalization in cancer cells [76]. In another work, Naqshbandi and Rahman [77] reported that the negative zeta potential favours the fixation and proliferation of bone cells by increasing the adsorption of Ca 2+ ions since the binding of such cells is dependent on the adsorption of ions Ca 2+ .…”

Section: Tablementioning

confidence: 99%

Nanostructured system based on hydroxyapatite and curcumin: A promising candidate for osteosarcoma therapy

Marinho

Neme

Matos

et al. 2023

Ceramics International

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“…[14,39] Smart nanocurcumins systems can be fabricated in different types such as gold nano particles, [41] Nano liposomes, [42] magnetic particles, [43] nanogels, [44] micelles, [45] and nanospheres. [46] There are many advantages for nano drugs such as reducing side effects and improving efficacy. [47,48] As a result of its insoluble character, zein has been widely explored among the biomaterials that might be used to improve the colloidal features of controlled delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed curcumin‐zein@polycaprolactone‐mucilage capsules for an improved sustained release

Shahbazi

Akbari

Baniasadi

2023

Polymer Engineering & Sci

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Nanocapsules of curcumin-zein as core and polycaprolactone-mucilage (PCL-MUC) as a shell were effectively made by using an electrospray process for drug delivery applications. Because of its anticancer and anti-inflammatory qualities, curcumin (Cur) was chosen as a model medicine, and its stability was improved by combining it with zein. The monodisperse and spherical shapes of CUR-ZEIN@PCL-MUC nanocapsules with an average diameter of 200 nm were obtained and validated by SEM and TEM images by altering spinning voltage, flow rates, polymeric concentrations, and drug content. FTIR was used to determine the chemical structure of the nanocapsules. In addition, the in vitro release was investigated, with samples exhibiting a burst release for the first 6 h followed by a sustained release for the next 24 h. The results show that adding opuntia mucilage and zein improved the curcumin release rate. Overall, 30% curcumin release was observed after 24 h, as described by the Ritger-Peppas model.

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Curcumin nanospheres and nanorods: Synthesis, characterization and anticancer activity

Cited by 11 publications

References 29 publications

Development of Computational In Silico Model for Nano Lipid Carrier Formulation of Curcumin

Development of Computational In Silico Model for Nano Lipid Carrier Formulation of Curcumin

Nanostructured system based on hydroxyapatite and curcumin: A promising candidate for osteosarcoma therapy

Electrosprayed curcumin‐zein@polycaprolactone‐mucilage capsules for an improved sustained release

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