Nanostructured system based on hydroxyapatite and curcumin: A promising candidate for osteosarcoma therapy

Marinho, Jéssica Pauline Nunes; Neme, Natália Paz; Matos, Matheus J. S.; Batista, Ronaldo J. C.; Macedo, W. A. A.; Gastelois, Pedro Lana; Gomes, Dawidson Assis; Rodrigues, Michele Ângela; Cipreste, Marcelo Fernandes; Sousa, Edésia Martins Barros de

doi:10.1016/j.ceramint.2023.03.115

Cited by 10 publications

(7 citation statements)

References 86 publications

(118 reference statements)

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“…The characteristic peaks at 32 • , 33 • , and 34 • Bragg angles (2θ) can be assigned to crystallographic planes (211), (300), and (202), respectively, in agreement with the literature [27]. Similar studies showed the formation of HA phase, confirmed by the appearance of characteristic patterns in the Bragg angles [28,29].…”

Section: X-ray Diffraction (Xrd)supporting

confidence: 87%

“…Figure 5 shows the FTIR spectra for HA, HA-Eu(2%)-Gd(1%), MSN/HA-Eu(2%)-Gd(1%) and MSN/HA-Eu(2%)-Gd(1%)/P(MAA). The spectra evidence the presence of hydroxyapatite in all the samples, due to the characteristic transmittance of the phosphate (1098–1037, 960, 603, 560, and 470 cm −1 ) and hydroxyl stretching (3571 and 638 cm −1 ) [ 22 , 28 , 36 ]. The vibrational modes of carbonate (CO 3 2− ), can be observed around 1454–1412 cm −1 in the spectra obtained for HA and HA-Eu(2%)-Gd(1%) samples.…”

Section: Resultsmentioning

confidence: 99%

“…The vibrational modes of carbonate (CO 3 2− ), can be observed around 1454–1412 cm −1 in the spectra obtained for HA and HA-Eu(2%)-Gd(1%) samples. Possibly, these ions may have arisen owing to exposure to atmospheric CO 2 or to CTAB decomposition during the calcination process [ 28 , 29 ].…”

Section: Resultsmentioning

confidence: 99%

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pH-Sensitive Hybrid System Based on Eu3+/Gd3+ Co-Doped Hydroxyapatite and Mesoporous Silica Designed for Theranostic Applications

et al. 2023

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Nanomaterials such as pH-responsive polymers are promising for targeted drug delivery systems, due to the difference in pH between tumor and healthy regions. However, there is a significant concern about the application of these materials in this field due to their low mechanical resistance, which can be attenuated by combining these polymers with mechanically resistant inorganic materials such as mesoporous silica nanoparticles (MSN) and hydroxyapatite (HA). Mesoporous silica has interesting properties such as high surface area and hydroxyapatite has been widely studied to aid in bone regeneration, providing special properties adding multifunctionality to the system. Furthermore, fields of medicine involving luminescent elements such as rare earth elements are an interesting option in cancer treatment. The present work aims to obtain a pH-sensitive hybrid system based on silica and hydroxyapatite with photoluminescent and magnetic properties. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), nitrogen adsorption methods, CHN elemental analysis, Zeta Potential, scanning electron microscopy (SEM), and transmission electron microscopy (TEM), vibrational sample magnetometry (VSM), and photoluminescence analysis. Incorporation and release studies of the antitumor drug doxorubicin were performed to evaluate the potential use of these systems in targeted drug delivery. The results showed the luminescent and magnetic properties of the materials and showed suitable characteristics for application in the release of pH-sensitive drugs.

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Section: X-ray Diffraction (Xrd)supporting

confidence: 87%

Section: Resultsmentioning

confidence: 99%

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pH-Sensitive Hybrid System Based on Eu3+/Gd3+ Co-Doped Hydroxyapatite and Mesoporous Silica Designed for Theranostic Applications

et al. 2023

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“…9 b were all found to be negative. This is believed to be due to the presence of OH - groups, which ionize to O 2 − and H + 75 . Additionally, both PO 4 3− and OH − groups are oriented on the outer surface of the Hap unit cell 76 .…”

Section: Ftir Resultsmentioning

confidence: 99%

Correlation between positron annihilation lifetime and photoluminescence measurements for calcined Hydroxyapatite

Atta,

Mahmoud,

Salim

et al. 2024

Sci Rep

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Hydroxyapatite (HAp) Ca10(PO4)6(OH)2 is a compound that has stable chemical properties, composition, and an affinity for human bone. As a result, it can be used in odontology, cancer treatment, and orthopedic grafts to repair damaged bone. To produce calcined HAp at 600 °C with different pH values, a wet chemical precipitation method was employed. All synthesized HAp samples were characterized by X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), photoluminescence (PL), Zeta potential, and positron annihilation lifetime spectroscopy (PALS). The XRD results revealed that all calcined HAp samples were formed in a hexagonal structure with a preferred (002) orientation at different pH values. The crystal size of the samples was determined using the Scherrer equation, which ranged from 16 to 25 nm. The SEM and TEM results showed that the morphology of the samples varied from nanorods to nanospheres and rice-like structures depending on the pH value of the sample. The PL measurements indicated that the blue and green emission peaks of HAp were due to defects (bulk, surface, and interface) in the samples, which created additional energy levels within the band gap. According to Zeta potential measurements, the charge carrier changed from a positive to negative value, ranging from 3.94 mV to − 2.95 mV. PALS was used to understand the relationship between the defects and the photoluminescence (PL) properties of HAp. Our results suggest that HAp nanoparticles have excellent potential for developing non-toxic biomedical and optical devices for phototherapy.

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“…El grupo CO 3 2− se asocia con las bandas ubicadas a ∼870 y 1420 cm -1 , la presencia de estas bandas sugiere la obtención de HAp carbonatada de tipo B, en la que el carbonato sustituye a los grupos fosfato en los sitios aniónicos en la estructura de la HAp. Además, según la literatura, el carbonato presente en la fase mineral del tejido óseo es, en su mayor parte, de tipo B, lo que aumenta la similitud química de la HAp sintetizada con la biológica (Kalpana & Nagalakshmi, 2023;Nunes et al, 2023). La deconvolución de los espectros entre 500 y 1250 cm -1 corresponde a: HAp-HB (a-2), HAp-CH (b-2), HAp-CC (c-2) y HAp-NC (d-2); en ellas se observa de manera más evidente el cambio en la intensidad de las bandas correspondientes a los mismos grupos funcionales.…”

Section: Resultsunclassified

Efecto del precursor de calcio en las propiedades estructurales y microestructurales de la hidroxiapatita

Villaquiran Raigoza,

Durán Montoya,

Gaona Jurado

2024

reveia

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Debido a que en la actualidad las afecciones óseas siguen siendo un desafío clínico significativo y las soluciones son limitadas y en algunos casos poco efectivas, la investigación alrededor de la hidroxiapatita, principal componente mineral del hueso ha cobrado una importancia relevante. En este trabajo de investigación se analizó el efecto del precursor de calcio en las características estructurales y microestructurales de la hidroxiapatita, comparando los resultados obtenidos con hidroxiapatita extraída de una fuente natural. Mediante el método de reacción por combustión en solución fueron sintetizados polvos de hidroxiapatita utilizando como precursores de calcio carbonato de calcio extraído de la cáscara de huevo y carbonato y nitrato de calcio comerciales. A su vez, la fuente natural de hidroxiapatita fue hueso bovino, que se sometió a un proceso de lavado, fractura y tratamiento térmico. Los grupos funcionales presentes en las muestras obtenidas fueron determinados mediante espectroscopia infrarroja y las fases cristalinas mediante difracción de rayos-X. La microscopía electrónica de transmisión permitió determinar la morfología esférica de las partículas obtenidas a partir de carbonato de calcio (de cáscara de huevo) con el menor tamaño de partícula (entre 20 y 50 nm); mientras que, las obtenidas a partir de precursores comerciales presentaron una morfología no homogénea. Los resultados mostraron que el proceso seguido fue eficiente para la obtención de nanopartículas de hidroxiapatita cuando se obtiene a partir de carbonato de calcio y a una temperatura de 1100ºC. El carbonato de calcio proveniente de la cáscara de huevo permitió obtener hidroxiapatita con morfología homogénea y tamaño nanométrico.

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Nanostructured system based on hydroxyapatite and curcumin: A promising candidate for osteosarcoma therapy

Cited by 10 publications

References 86 publications

pH-Sensitive Hybrid System Based on Eu3+/Gd3+ Co-Doped Hydroxyapatite and Mesoporous Silica Designed for Theranostic Applications

pH-Sensitive Hybrid System Based on Eu3+/Gd3+ Co-Doped Hydroxyapatite and Mesoporous Silica Designed for Theranostic Applications

Correlation between positron annihilation lifetime and photoluminescence measurements for calcined Hydroxyapatite

Efecto del precursor de calcio en las propiedades estructurales y microestructurales de la hidroxiapatita

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