Curcumin Mitigates Accelerated Aging after Irradiation inDrosophilaby Reducing Oxidative Stress

Abstract

Curcumin, belonging to a class of natural phenol compounds, has been extensively studied due to its antioxidative, anticancer, anti-inflammatory, and antineurodegenerative effects. Recently, it has been shown to exert dual activities after irradiation, radioprotection, and radiosensitization. Here, we investigated the protective effect of curcumin against radiation damage using D. melanogaster. Pretreatment with curcumin (100 μM) recovered the shortened lifespan caused by irradiation and increased eclosion rate. Flies subjected to high-dose irradiation showed a mutant phenotype of outstretched wings, whereas curcumin pretreatment reduced incidence of the mutant phenotype. Protein carbonylation and formation of γH2Ax foci both increased following high-dose irradiation most likely due to generation of reactive oxygen species. Curcumin pretreatment reduced the amount of protein carbonylation as well as formation of γH2Ax foci. Therefore, we suggest that curcumin acts as an oxidative stress reducer as well as an effective protective agent against radiation damage.

Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast

“…Due to antioxidant properties of curcumin, its effect on viability of fruit flies exposed to radiation was also evaluated. It turned out that administration of curcumin to the tested individuals protects their cells against damage caused by radiotherapy and extends their lives, and therefore may provide effective protection against radiation (Seong et al 2015). In addition to analysis of anti-oxidative action, the studies also included analysis of acetylcholinesterase (AChE) activity in relation to extension of the fruit fly's life.…”

Vive la radiorésistance!: converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization

“…In other words, ionizing radiation causes accelerated aging both at the cell level (stress-induced premature senescence) and in the body [ 66 , 216 ]. Therefore, it is not surprising that some geroprotectors (pharmacological agents that decrease the rate of aging and extend the lifespan) are able to reduce the damaging effect of ionizing radiation, for instance, curcumin [ 217 ], quercetin, (−)-epicatechin, and ibuprofen [ 218 ]. At the present day, according to Geroprotectors.org ( http://geroprotectors.org/ ) [ 219 ] and DrugAge ( http://genomics.senescence.info/drugs/ ) [ 220 ] databases, there are more than 400 potential geroprotectors, compounds that prolong model organism's life span at least in one concentration [ 221 ] (Figure 4 ).…”

Effects of Temperature on Lifespan of Drosophila melanogaster from Different Genetic Backgrounds: Links between Metabolic Rate and Longevity

“…On the one hand, the length of life may be extended by dietary or caloric restriction; on the other hand, it may be reduced by a fat-rich diet [14,15]. Also, many biologically active compounds (e.g., naringenin or curcumin) determine lifespan [15,16]. Temperature may also affect lifespan, presumably by changing energy status [17].…”