Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats

El‐Naggar, Mehrez E.; Al-Joufi, Fakhria A.; Anwar, Mona; Attia, Mohamed F.; El‐Bana, Mona A.

doi:10.1016/j.colsurfb.2019.02.024

Cited by 103 publications

(51 citation statements)

References 41 publications

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“…The curcumin-loaded nanoparticles were found to attenuate diabetic neuropathy via suppressing interleukin-1β (IL-1β), connexin43, and phosphorylated protein kinase B (Akt) expressions in dorsal root ganglia and downregulating purinergic 2 (P2) Y12 receptor mRNA expression in satellite glial cells of diabetic rats [198]. Curcumin-loaded polylactic acid (PLA)-polyethylene glycol (PEG) polymeric nanoparticles were found to be effective through the oral route in reciprocating hyperglycaemia, hypoinsulinemia, and diabetes-provoked hepatotoxicity more effectively than free curcumin [199]. Curcumin-PLA-PEG nanoparticles could attenuate hepatotoxicity by mitigating hepatic oxidative stress, inflammation, and fibrosis through suppression of respective signalling events [199].…”

Section: Curcuminmentioning

confidence: 99%

“…Curcumin-loaded polylactic acid (PLA)-polyethylene glycol (PEG) polymeric nanoparticles were found to be effective through the oral route in reciprocating hyperglycaemia, hypoinsulinemia, and diabetes-provoked hepatotoxicity more effectively than free curcumin [199]. Curcumin-PLA-PEG nanoparticles could attenuate hepatotoxicity by mitigating hepatic oxidative stress, inflammation, and fibrosis through suppression of respective signalling events [199]. Curcumin-loaded chitosan nanoparticles were found to improve muscle cell glucose uptake capacity of curcumin in vitro via enhancing its solubility [200].…”

Section: Curcuminmentioning

confidence: 99%

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Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Section: Curcuminmentioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

View full text Add to dashboard Cite

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“…The addition of curcumin-loaded nanocapsules produced from the Eudragit L-100 polymer to the diets of dairy sheeps resulted in a higher antioxidant capacity and lower lipid peroxidation in their milk (Jaguezeski et al, 2019). Anti-inflammatory activities of different curcumin-loaded nanocomposites were also repeatedly reported (Wang et al, 2015a;Ameruoso et al, 2017;Dewangan et al, 2017;El-Naggar et al, 2019).…”

Section: Nano-curcuminmentioning

confidence: 86%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

145

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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“…The fourth group (G4, protected) was injected with an intraperitoneal (IP) dose of nanocurcumin (20 mg/kg) daily for two weeks before induction of immunosuppression. CP was administered in G2, G3 and G4 at days 1, 2, 3, and 20 following initial validation [19]. Twenty-four hours after administration of the last dosage, two separate blood samples were collected from the retro-orbital plexus from each rat; the first blood samples were collected in serum tubes and left to coagulate at room temperature for 20 min, the resultant serum was separated after centrifugation at 3000 rpm for 15 min and stored at -20 ° C until used in determining IgG and IgM concentration.…”

Section: Experimental Designmentioning

confidence: 99%

Ameliorative Effects of Nanocurcumin on Cyclophosphamide Induced Immunosuppression in Male Rats

El-Dawy

Soliman

Arisha

2020

Zagazig Veterinary Journal

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Curcumin, an active component of turmeric, possesses different protective functions due to its anti-inflammatory, anti-oxidative and immunomodulatory activities. Curcumin's medicinal use is restricted as a result of low solubility, instability, poor bioavailability and rapid metabolism. Nanocurcumin is an enhanced form with higher tissue distribution, improved internalization and reduced systemic elimination than curcumin. Cyclophosphamide (CP), the anticancer alkylating agent, is proved to be useful for managing a wide range of cancers. Its use is limited due to harmful effects including the induction of both oxidative stress and immunosuppression. The present study evaluated the immuno-enhancement and protective properties of nanocurcumin in an immunosuppressed rat model. The experimental rats were divided into four groups (control, immunosuppressed, treated and protected) of ten rats each. Both treatment and protection trials of immunosuppressed rats with nanocurcumin significantly increased indices of spleen (119.83 and 128.61%) and liver (104.95 and 109.74%), respectively as well as the levels of immunoglobulins (IgG, 148.85 and 197.62% and IgM, 144.09% and 211.51%, respectively) beside the enhancement of the phagocytic activity of macrophages (122.37 and 156.16% respectively), in comparison with immunosuppressed rats. Both approaches down-regulated the proinflammatory cytokines comprising TNF-α (15.91 and 13.23%, respectively) and IL-1β (74.22 and 36.98%, respectively), while they upregulated the anti-inflammatory cytokines (IL-10, 130.59 and 184.68%, respectively) in splenic expression. In hepatic mRNA expression of TNF-α, both treatment and protection approaches significantly down-regulated their transcriptional level (19.17 and 46.38%, respectively), but no significant variations were reported in IL-1β expression (100.12 and 103.42%, respectively), whereas both approaches significantly up-regulated IL-10 (170.13 and 264.51%, respectively). Also, nanocurcumin restored the integrity of DNA in hepatic tissue. The protected group had more ameliorative effects than the one being treated. It could be concluded that nanocurcumin has a potential or even a vital protective activity against immunodepression in CP administered rats and could be used as an immunomodulatory agent.

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Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats

Cited by 103 publications

References 41 publications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Ameliorative Effects of Nanocurcumin on Cyclophosphamide Induced Immunosuppression in Male Rats

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