Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats

El‐Naggar, Mehrez E.; Al-Joufi, Fakhria A.; Anwar, Mona; Attia, Mohamed F.; El‐Bana, Mona A.

doi:10.1016/j.colsurfb.2019.02.024

Cited by 96 publications

(46 citation statements)

References 41 publications

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“…When detecting the effect of hesperidin in diethylnitrosamine‐induced hepatocarcinogenesis, Mahmoud found that hesperidin ameliorates oxidative stress and inflammation, dramatically up‐regulates the expression of PPARγ, and significantly prevents liver damage . The anti‐inflammatory effect of curcumin, a natural polyphenolic compound, was reported by El‐Naggar et al In streptozotocin‐induced diabetic rats, the up‐regulation of alanine aminotransferase, aspartate aminotransferase, cyclooxygenase, transforming growth factor‐β1 and nuclear factor kappa B were reversed by curcumin via its promotion of PPARγ expression. In an investigation of the jellyfish‐derived fungus, Penicillium chrysogenum J08NF‐4, researchers described a new meroterpene derivative, chrysogenester, which has been defined as a PPARγ agonist.…”

Section: Pparγ Natural Agonists and Liver Diseasesmentioning

confidence: 94%

Therapeutic potential of PPARγ natural agonists in liver diseases

Guo

2020

J Cellular Molecular Medi

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Peroxisome proliferator‐activated receptor gamma (PPARγ) is a vital subtype of the PPAR family. The biological functions are complex and diverse. PPARγ plays a significant role in protecting the liver from inflammation, oxidation, fibrosis, fatty liver and tumours. Natural products are a promising pool for drug discovery, and enormous research effort has been invested in exploring the PPARγ‐activating potential of natural products. In this manuscript, we will review the research progress of PPARγ agonists from natural products in recent years and probe into the application potential and prospects of PPARγ natural agonists in the therapy of various liver diseases, including inflammation, hepatic fibrosis, non‐alcoholic fatty liver and liver cancer.

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Section: Pparγ Natural Agonists and Liver Diseasesmentioning

confidence: 94%

Therapeutic potential of PPARγ natural agonists in liver diseases

Guo

2020

J Cellular Molecular Medi

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“…The curcumin-loaded nanoparticles were found to attenuate diabetic neuropathy via suppressing interleukin-1β (IL-1β), connexin43, and phosphorylated protein kinase B (Akt) expressions in dorsal root ganglia and downregulating purinergic 2 (P2) Y12 receptor mRNA expression in satellite glial cells of diabetic rats [198]. Curcumin-loaded polylactic acid (PLA)-polyethylene glycol (PEG) polymeric nanoparticles were found to be effective through the oral route in reciprocating hyperglycaemia, hypoinsulinemia, and diabetes-provoked hepatotoxicity more effectively than free curcumin [199]. Curcumin-PLA-PEG nanoparticles could attenuate hepatotoxicity by mitigating hepatic oxidative stress, inflammation, and fibrosis through suppression of respective signalling events [199].…”

Section: Curcuminmentioning

confidence: 99%

“…Curcumin-loaded polylactic acid (PLA)-polyethylene glycol (PEG) polymeric nanoparticles were found to be effective through the oral route in reciprocating hyperglycaemia, hypoinsulinemia, and diabetes-provoked hepatotoxicity more effectively than free curcumin [199]. Curcumin-PLA-PEG nanoparticles could attenuate hepatotoxicity by mitigating hepatic oxidative stress, inflammation, and fibrosis through suppression of respective signalling events [199]. Curcumin-loaded chitosan nanoparticles were found to improve muscle cell glucose uptake capacity of curcumin in vitro via enhancing its solubility [200].…”

Section: Curcuminmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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“…The addition of curcumin-loaded nanocapsules produced from the Eudragit L-100 polymer to the diets of dairy sheeps resulted in a higher antioxidant capacity and lower lipid peroxidation in their milk (Jaguezeski et al, 2019). Anti-inflammatory activities of different curcumin-loaded nanocomposites were also repeatedly reported (Wang et al, 2015a;Ameruoso et al, 2017;Dewangan et al, 2017;El-Naggar et al, 2019).…”

Section: Nano-curcuminmentioning

confidence: 86%

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

Vaiserman

Koliada

Zayachkivska

et al. 2020

Front. Bioeng. Biotechnol.

128

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The aging process is known to be associated with heightened oxidative stress and related systemic inflammation. Therefore, antioxidant supplementation is regarded as a promising strategy to combat aging and associated pathological conditions. Food-grade antioxidants from plant-derived extracts are the most common ingredients of these supplements. Phyto-bioactive compounds such as curcumin, resveratrol, catechins, quercetin are among the most commonly applied natural compounds used as potential modulators of the free radical-induced cellular damages. The therapeutic potential of these compounds is, however, restricted by their low bioavailability related to poor solubility, stability, and absorbance in gastrointestinal tract. Recently, novel nanotechnology-based systems were developed for therapeutic delivery of natural antioxidants with improved bioavailability and, consequently, efficacy in clinical practice. Such systems have provided many benefits in preclinical research over the conventional preparations, including superior solubility and stability, extended half-life, improved epithelium permeability and bioavailability, enhanced tissue targeting, and minimized side effects. The present review summarizes recent developments in nanodelivery of natural antioxidants and its application to combat pathological conditions associated with oxidative stress.

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Curcumin-loaded PLA-PEG copolymer nanoparticles for treatment of liver inflammation in streptozotocin-induced diabetic rats

Cited by 96 publications

References 41 publications

Therapeutic potential of PPARγ natural agonists in liver diseases

Therapeutic potential of PPARγ natural agonists in liver diseases

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Nanodelivery of Natural Antioxidants: An Anti-aging Perspective

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